A5101750328- Genomics and Phylogenetic Studies
- Probiotics and Fermented Foods
- Gut microbiota and health
- Tissue Engineering and Regenerative Medicine
- Genomics and Rare Diseases
- Urological Disorders and Treatments
- Phytoestrogen effects and research
- Plant and Fungal Species Descriptions
- Tea Polyphenols and Effects
- Genomic variations and chromosomal abnormalities
- Biomedical Text Mining and Ontologies
- Clostridium difficile and Clostridium perfringens research
- Food Quality and Safety Studies
- Animal Disease Management and Epidemiology
- Microbial Natural Products and Biosynthesis
- Mycobacterium research and diagnosis
- Digestive system and related health
- Natural Compounds in Disease Treatment
- Machine Learning in Bioinformatics
- Autism Spectrum Disorder Research
- Bacteriophages and microbial interactions
- Traditional Chinese Medicine Analysis
- Plant Pathogens and Fungal Diseases
- Animal Virus Infections Studies
- Viral Infections and Immunology Research
Vanderbilt University
2021-2025
Hunan University of Science and Engineering
2019-2024
Guangxi University
2009-2024
Nanchang University
2024
Wuyi University
2021-2022
Wuyi University
2021-2022
Guangdong Academy of Agricultural Sciences
2022
Ministry of Agriculture and Rural Affairs
2022
Institute of Agricultural Resources and Regional Planning
2018
Chinese Academy of Agricultural Sciences
2018
Abstract Background Chloroplast genome resources can provide useful information for the evolution of plant species. Tea ( Camellia sinensis ) is among most economically valuable member . Here, we determined chloroplast first natural triploid Chinary type tea (‘Wuyi narcissus’ cultivar var. , CWN and conducted comparison with diploid CSS two types Assamica teas assamica : Chinese tea, CSA Indian CIA ). Further, evolutionary mechanism relationships species based on were discussed. Results...
An efficient, one-pot approach has been established for synthesizing a wide range of 3-amino-[1,2,4]-triazolo pyridines and related heterocycles from the electrochemically induced desulfurative cyclization 2-hydrazinopyridines with isothiocyanates. The protocol allows formation C–N bonds under simple conditions without transition metals or external oxidants. practicability this strategy is demonstrated by its broad substrate scope, good functional group compatibility, gram-scale synthesis....
Abstract Intra-tumor heterogeneity (ITH) is a compounding factor for cancer prognosis and treatment. Single-cell DNA sequencing (scDNA-seq) provides cellular resolution of the variations in cell has been widely used to study progression responses drug While low coverage scDNA-seq technologies typically large number cells, accurate clustering essential effectively characterizing ITH. Existing methods are based on either single nucleotide (SNV) or copy alterations (CNA), without leveraging...
Bifidobacteria are a very important group of gut microbiota, and the presence these bacteria has many beneficial effects for host. Thus, bifidobacteria have attracted growing interest owing to their potential probiotic properties.
Statins, a class of drugs that can effectively remove cholesterol from serum, are used to regulate plasma total and reduce the risk cardiovascular diseases, but it is still unclear whether drug modulated by gut microbiota or structures shaped statins. We investigated interactions between statins human during in vitro fermentation process 16S rRNA gene sequencing, gas chromatography (GC), high-performance liquid (HPLC) analyses. The presence fluvastatin (FLU2) specifically promoted growth...
Deinagkistrodon acutus is a venomous pit viper commonly used in traditional Chinese medicine; farming these snakes has become major industry. In 2017, an outbreak of fatal diarrhoea among farm-raised D. Hunan Province caused the deaths 5,600 within 3 weeks. We isolated brand-new sequence type Aeromonas hydrophila (ST516) from lesions and confirmed that this bacterium was causal agent outbreak. Snakes infected with laboratory showed similar clinical symptoms to those original also tested...
Abstract With the rapid advancement and generation of spatial transcriptomics (ST), integrating data from multiple ST slices is increasingly crucial for joint slice analysis. Nevertheless, tasks learning embeddings identifying shared unique cell/domain types across remain challenging. To address this, we introduce a method called MaskGraphene, purpose better aligning different using both self-supervised contrastive learning. MaskGraphene learns to capture geometric information efficiently....
With its estrogenic activity, (
Bacterial surface proteins can be good vaccine candidates. In the present study, we used polyclonal antibodies purified with intact Erysipelothrix rhusiopthiae to screen phage-displayed random dodecapeptide and loop-constrained heptapeptide libraries, which led identification of mimotopes. Homology search mimotope sequences against rhusiopthiae-encoded ORF revealed 14 new antigens that may localize on rhusiopthiae. When these putative were immunize mice, 9/11 induced protective immunity....
Here, combining PacBio and Illumina sequencing data, we reported the complete chloroplast genome of first Wuyi tea (Bohea), Camellia sinensis cv. Dahongpao (DHP) with very high economic value. The was 157,077 bp in length, a large single copy (LSC) region 86,633 bp, small single-copy (SSC) 18,282 separated by two inverted repeat (IR) regions 26,081 each. It contained total 137 genes, an overall GC content 37.29%. phylogenetic analysis showed that DHP sister to C. Longjing.
Colorectal polyps, which are characterized by a high recurrence rate, represent preneoplastic conditions of the intestine. Due to unclear mechanisms pathogenesis, first-line therapies for non-hereditary recurrent colorectal polyps limited endoscopic resection. Although recent studies suggest mechanistic link between intestinal dysbiosis and exact compositions roles bacteria in mucosa around lesions, rather than feces, remain unsettled.
A random 12-peptide library was screened against Erysipelothrix rhusiopthiae and porcine circovirus 2 recombinant Cap protein the selected peptides were used for detecting corresponding pathogens quickly effectively. To our surprise, seven peptides, P1 (WHWNAP WWNGVY), P2 (FHWTWQFPYTST), P3 (GAMHLPWHMGTL), P4 (HWNIWWQHHPSP), P5 (HFFKWHTRTNDQ), P6 (HFFRWHPSAHLG) P7 (HFAYWWNGVRGP) with characteristics of polystyrene plate (PS) binding target-unrelated (TUPs), from library. It has been found...
Two isolates of a new classical swine fever virus (CSFV) subgenotype, 2.1c (HNLY-2011 and HNSD-2012), were recently isolated from pigs in Hunan Province, China. The most significant difference the amino acid sequences polyproteins subgenotypes 2.1a 2.1b is an SPA → TPV substitution at positions 777 779 E2 protein.
To investigate the curative effect and histo-compatibility of reconstruction traumatic urethral defect rabbit using extracellular matrix (ECM). Urethral ECM was obtained by excision urethra in 20 donor rabbits. In experimental group, rabbits were resected a 1.0 cm-1.5 cm segment artificially made model defect, then reconstructed same length. The immunity response assessed lymphocyte transformation test serum TNF-α level. segments stained with hematoxylin-eosin Van Gieson stain observed...
Wuyi tea (Camellia. sinensis, Synonym: Thea Bohea L.) is recognized as the most prestigious oolong in China. For germplasm identification and protection, complete chloroplast genomes of five classical varieties were determined by next-generation sequencing. These showed highly conserved structures are 157,024-157,126 bp length, consisting a pair reverse repeats (IR) regions 25,944-26,095 bp, one large single-copy (LSC) region 86,594-86,859 small single copy (SSC) 18,276-18,291 bp. A total...
A stable intestinal microflora is an essential prerequisite for human health. This study investigated the interaction between Escherichia coli exopolysaccharides (named EPS-m2) and gut microbiota (HGM) in vitro . The EPS-m2 was produced by E WM3064 when treated with ceftriaxone. monosaccharide composition analysis revealed that composed of glucuronic acid, glucose, fucose, galactose/N-acetyl glucosamine, arabinose, xylose, ribose a molar ratio approximately 77:44:29:28:2:1:1. carbohydrates,...
(S)-equol (EQ) is an isoflavone with high estrogen-like activity in the human body, and only produced by some gut bacteria vivo. It plays important role maintaining individual health, however, dearth of resources associated (S)-EQ-producing has seriously restricted production application (S)-EQ. We report here a new functional gene KEC48-07020 (K-07020) that was identified from chick bacterium (Clostridium sp. ZJ6, ZJ6). found recombinant protein K-07020 possessed similar function to...