A5100343772- Neonatal and fetal brain pathology
- Advanced Neuroimaging Techniques and Applications
- Fetal and Pediatric Neurological Disorders
- Bladder and Urothelial Cancer Treatments
- Advanced MRI Techniques and Applications
- Liver Disease Diagnosis and Treatment
- Traditional Chinese Medicine Analysis
- Gastric Cancer Management and Outcomes
- Bone and Joint Diseases
- Hepatocellular Carcinoma Treatment and Prognosis
- Phytochemistry and Biological Activities
- Bone health and osteoporosis research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Respiratory viral infections research
- Cancer, Lipids, and Metabolism
- Infant Development and Preterm Care
- Cerebral Palsy and Movement Disorders
- Ultrasound Imaging and Elastography
- Cancer-related Molecular Pathways
- Epigenetics and DNA Methylation
- Autophagy in Disease and Therapy
- Genetic factors in colorectal cancer
- Herpesvirus Infections and Treatments
- Parasitic infections in humans and animals
- Influenza Virus Research Studies
Jiangsu University
2015-2025
Institute of Geographic Sciences and Natural Resources Research
2025
Fujian Academy of Agricultural Sciences
2025
Chinese Academy of Sciences
2016-2025
Nanjing University of Chinese Medicine
2015-2025
First Affiliated Hospital of Xi'an Jiaotong University
2016-2025
Qingdao University
2023-2025
Affiliated Hospital of Qingdao University
2023-2025
Nantong University
2024
Shaanxi University of Science and Technology
2023-2024
Posttraumatic osteoarthritis (PTOA) patients are often diagnosed by X-ray imaging at a middle-late stage when drug interventions less effective. Early PTOA is characterized overexpressed matrix metalloprotease 13 (MMP13). Herein, we constructed an integrated diagnosis and treatment micelle modified with MMP13 enzyme-detachable, cyanine 5 (Cy5)-containing PEG, black hole quencher-3 (BHQ3), cRGD ligands loaded siRNA silencing (siM13), namely ERMs@siM13. ERMs@siM13 could be cleaved in the...
Abstract Introduction The aim of this study was to evaluate the early diagnostic, risk stratification and prognostic value neutrophil gelatinase-associated lipocalin (NGAL), matrix metalloproteinase-9 (MMP-9) tissue inhibitor metalloproteinases-1 (TIMP-1), compared with procalcitonin (PCT) Mortality in Emergency Department Sepsis (MEDS) score septic patients emergency department (ED). Methods In total, 480 consecutive adult were enrolled study. They fulfilled systemic inflammatory response...
Abstract Paclitaxel, a known TLR4 ligand, leads to activation of TLR4/MyD88-dependent pathway that mediates chemoresistance and tumor progression in epithelial ovarian carcinoma (EOC). Atractylenolide-I (AO-I), novel TLR4-antagonizing agent, inhibits signaling by interfering with the binding LPS or paclitaxel membrane human leukocytes. In this study, AO-I was found attenuate paclitaxel-induced protein expression IL-6, VEGF survivin enhance early apoptosis growth inhibition MyD88 + EOC cells;...
Abstract Background We retrospectively analyzed 26 persistently asymptomatic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) carriers. Methods Epidemiological and clinical characteristics from the patients with positive results for SARS-CoV-2 ribonucleic acid testing were obtained. Results Twenty-two (84.6%) correlated clustering occurrence. The median period contact to diagnosis last nucleic test was 19 (8–24 days) 21.5 days (10–36 days), respectively. negative significantly...
With the enormous morbidity and mortality caused by respiratory syncytial virus (RSV) infections among infants elderly, vaccines against RSV are in large market demand.We conducted a first-in-human (FIH), randomized, double-blind, placebo-controlled dose escalation study to evaluate safety immunogenicity response of rRSV vaccine (BARS13) healthy adults aged 18-45. A total 60 eligible participants were randomly assigned receive one four levels or vaccination regimens BARS13 placebo at 4:1...
Rationale: Stem cells self-organize to form organoids that generate mini-organs resemble the physiologically-developed ones.The mechanism by which stem acquire initial potential for generating remains elusive.Here we used skin as an example study how mechanical force drives epidermal-dermal interaction potentiates regenerate hair follicles.Methods: Live imaging analysis, single-cell RNA-sequencing and immunofluorescence were analyze contractile of dermal in organoids.Bulk calcium probe...
Rationale: An elevated level of plasma LDL (low-density lipoprotein) is an established risk factor for cardiovascular disease. Recently, we reported that the (pro)renin receptor ([P]RR) regulates metabolism in vitro via LDLR (LDL receptor) and SORT1 (sortilin-1), independently renin–angiotensin system. Objectives: To investigate physiological role (P)RR lipid vivo. Methods Results: We used N-acetylgalactosamine modified antisense oligonucleotides to specifically inhibit hepatic expression...
The clearance of activated hepatic stellate cells (HSCs) by apoptosis is critical for the reversibility fibrosis. Mitochondrial homeostasis regulated mitophagy, which an efficient way clearing injured mitochondria that plays important role in apoptosis. However, mitophagy HSCs and fibrosis still unclear. Here, we show enhanced parallel with increased during reversal inhibition suppressed aggravated mice. In contrast, activation induced HSCs. Furthermore, confirmed BCL-B, a member BCL-2...
Diabetes mellitus (DM), an emerging chronic epidemic, contributes to mortality and morbidity around the world. Diabetic cardiac autonomic neuropathy (DCAN) is one of most common complications associated with DM. Previous studies have shown that satellite glial cells (SGCs) in superior cervical ganglia (SCG) play indispensable role DCAN progression. In addition, it has been purinergic neurotransmitters, as well metabotropic GPCRs, are involved pathophysiological process DCAN. Furthermore,...
<abstract abstract-type="Abstract"> <sec> <b>Introduction</b> Varicella outbreaks significantly disrupt schools and other child-centered institutions. This study aimed to identify patterns epidemiological features of varicella in China from 2006 2022. </sec><sec> <b>Methods</b> Data were extracted outbreak reports submitted the Public Health Emergency Reporting Management Information System within specified timeframe. Analytical methods included Spearman correlation tests Mann-Kendall trend...
ABSTRACT Introduction As a widely used Chinese herbal medicine, Mume Fructus pulp (MFP) has rich nutritional value and biological activity, but its quality control research is relatively scarce. Objectives The objective of the study was to evaluate difference between MFPs from different origins adulterant apricot (APP), identify potential markers. Methods chemical compositions were identified by untargeted metabolomics analysis based on ultra‐performance liquid chromatography‐quadrupole...
Nitrogen source is a necessary nutrient factor in the process of mycelial growth and metabolite synthesis. To improve yield ergosterol, previous study, we used transcriptome technology to explore difference gene expression Cordyceps cicadae by CO(NH2)2 (urea) synthesizing ergosterol. In present was examine its effects on cell membrane permeability metabolic flow C. fermentation ergosterol Metabonomic results showed that supplementation caused significant changes five aspects: (1) notably...
To search for key drug resistance biomarkers and potential chemotherapeutic agents combination therapy in melanoma patients. The common up-regulated differentially expressed genes were acquired from two cohort studies, GSE91061 PRJEB23709. Univariate multivariate Cox regression survival analyses performed to screen important prognostic biomarkers. A multi-gene panel including APP, ARHGAP42, GSTA4 UCHL1, not only plays an role indicators, but also predicting the probability of anti-PD-1...
Fusarium crown rot of wheat, caused by pseudograminearum, significantly affects the yield and quality wheat worldwide. Here, Streptomyces noursei strain S86 (herein referred to as S86), was evaluated for its biocontrol efficacy biochemical characteristics. Strain found secrete cellulase, amylase other enzymes. Whole genome sequencing LC-MS analyses confirmed that could produce toyocamycin, nystatin, anisomycin, natamycin, antimicrobial metabolites. The fermentation broth inhibited growth F....
Mitophagy affects the activation of hepatic stellate cells (HSCs). Mitochondria-targeted ubiquinone (MitoQ) is a mitochondria-targeted antioxidant that reduces production intracellular reactive oxygen species (ROS). However, its relationship with mitophagy remains unclear. This study evaluated during HSC and effects MitoQ on in cell culture an animal model HSCs. We found reduced HSCs alleviated fibrosis. PINK1 (PTEN-induced putative kinase 1) serine/threonine located mitochondria's outer...
Galectin-14 is specifically expressed in placental trophoblasts, and its expression reduced trophoblasts retrieved from the cervix of women destined to develop early pregnancy loss. However, roles galectin-14 regulating pathogenesis complication have never been investigated. In current research, we aimed investigate regulation trophoblasts. Tissues placenta villi were collected. Primary human trophoblast cell line HTR-8/SVneo used. Western blotting RT-PCR used quantify gene expression. The...