A5090987460- Immune Cell Function and Interaction
- CAR-T cell therapy research
- IL-33, ST2, and ILC Pathways
- Cancer Immunotherapy and Biomarkers
- Neonatal and fetal brain pathology
- Functional Brain Connectivity Studies
- Medical Imaging and Analysis
- Immunotherapy and Immune Responses
- Advanced Neuroimaging Techniques and Applications
- Autopsy Techniques and Outcomes
- Infant Development and Preterm Care
- Hearing, Cochlea, Tinnitus, Genetics
- Whipple's Disease and Interleukins
- Hearing Loss and Rehabilitation
- Ultrasonics and Acoustic Wave Propagation
- Nuclear Receptors and Signaling
- Metastasis and carcinoma case studies
- Dental Radiography and Imaging
- Ultrasound Imaging and Elastography
- Gastrointestinal Tumor Research and Treatment
- interferon and immune responses
- Gastric Cancer Management and Outcomes
- Neurotransmitter Receptor Influence on Behavior
- Cytokine Signaling Pathways and Interactions
- PI3K/AKT/mTOR signaling in cancer
First Affiliated Hospital of Xi'an Jiaotong University
2021-2025
Tsinghua University
2019-2025
Center for Life Sciences
2025
Xi'an Jiaotong University
2023
In cancer, persistent antigens drive CD8+ T cell differentiation into exhausted progenitor (Texprog) and terminally (Texterm) cells. However, how the extrinsic intrinsic regulatory mechanisms cooperate during this process still remains not well understood. Here, we found that STAT3 signaling plays essential roles in promoting intratumor Texterm development by enhancing their effector functions survival, which results better tumor control. microenvironments, is predominantly activated IL-10...
Overcoming CD8+ T cell exhaustion is critical in cancer immunotherapy. Recently, an intratumor stem/progenitor-like (Tprog cell) population that mediates the persistence of antitumor responses has been defined, which can further develop into a terminally differentiated (Tterm subpopulation with potent cytotoxic functions. Tprog cells are main responders to immune checkpoint blockade therapies, yet how extrinsic signals via transcription factors control generation and tumors unclear. Here, we...
Abstract Background Chest radiography is the standard investigation for identifying rib fractures. The application of artificial intelligence (AI) detecting fractures on chest radiographs limited by image quality control and multilesion screening. To our knowledge, few studies have developed verified performance an AI model using multi-center radiographs. And existing multiple fracture detection used more complex slower algorithms, so we aimed to create a convolutional neural network (CNN),...
CD8
T cell activation is accompanied by extensive changes in epigenome. However, the high-ordered chromatin organization underpinning CD8+ not fully known. Here, we show three-dimensional genome during activation, associated with gene transcription. We that T-cell-specific deletion of Trim28 mice disrupts autocrine IL-2 production and leads to impaired vitro vivo. Mechanistically, TRIM28 binds regulatory regions genes formation chromosomal loops activation. At loop anchor regions,...
Ultrasonic B-mode imaging offers non-invasive and real-time monitoring of thermal ablation treatment in clinical use, however it faces challenges moderate lesion-normal contrast detection accuracy. Quantitative ultrasound techniques have been proposed as promising tools to evaluate the microstructure ablated tissue. In this study, we introduced Shannon entropy, a non-model based statistical measurement disorder, quantitatively detect monitor microwave-induced porcine livers. Performance...
Background Neonates with immature auditory function (eg, weak/absent middle ear muscle reflex) could conceivably be vulnerable to noise‐induced hearing loss; however, it is unclear if neonates show evidence of loss following MRI acoustic noise exposure. Purpose To explore the effects in neonates. Study Type Prospective. Subjects Two independent cohorts (N = 19 and N 18; mean gestational‐age, 38.75 ± 2.18 39.01 1.83 weeks). Field Strength/Sequence T1‐weighted three‐dimensional gradient‐echo...
Inflammatory bowel disease (IBD) is multi-factorial chronic intestinal inflammation driven by pathogenic T cells, among which a large portion of patients are resistant to current anti-inflammatory regimes. The mechanisms underlying colitis pathogenicity and drug resistance not fully understood. Here, we demonstrate that RORα highly expressed in active UC patients, particularly those non-responsive anti-TNF treatment. Rorα deficiency CD4+ cells greatly reduced development. Mechanistically,...
Innate lymphoid cells (ILC) are similar to T helper (Th) in expression of cytokines and transcription factors. For example, RORγt is the lineage-specific factor for both ILC3 Th17 cells. However, ILC counterpart BCL6-expressing follicular (Tfh) has not been defined. Here, we report that compartment, BCL6 selectively co-expressed with only CXCR5 but also CCR6 from multiple tissues. BCL6-deficient produces enhanced levels IL-17A IL-22. More importantly, phenotypic single-cell ATAC-seq analysis...
<p class="Abstract">In the present study, effect of trolox on human colon cancer cell lines was investigated. The results revealed that treatment caused inhibition growth in T84 and HCT-15 a dose-dependent manner. significant at 50 µM after 48 hours both lines. Trolox promoted expression p38 inhibited survivin Akt. It also induced cleavage PARP caspase-3 ultimately apoptosis cells. tumor significantly xenotransplanted mice with compared to control group. Since exhibits inhibitory...
Abstract Preterm infants show high risk for subsequent neurodevelopmental disability. Early developmental characterization of brain and neurobehavioral function is critical identifying the high-risk infants, thus guiding necessary intervention. This paper aims to elaborate early evolution preterm sensorimotor by exploring postnatal age-related changes white matter (WM) microstructure abilities during neonatal stage. One hundred eighteen neonates without abnormality on MRI were included....
Abstract Background: The application of artificial intelligence for the detection rib fractures on chest radiographs is limited by image quality control and multi-lesion screening. We aimed to create a model multiple fracture using convolutional neural network (CNN) based quality-normalised radiographs. Methods: A total 1,080 with were obtained randomly divided into training (918 graphs, 85%) testing (162 15%) sets. An object CNN, you only look once (YOLO) v3, was adopted build model....
Abstract Granger causality (GC) analysis and metabolic connectivity map (MCM) are two effective (EC) methods commonly used in functional brain researches. Although they have a common basis central neurophysiology, their differences depicting EC not clear because of absenting data acquired simultaneously exactly aligned. Integrated positron emission tomography magnetic resonance image (PET/MR) technology makes this available. Using the “Monash rs-PET/MR” dataset obtained from OpenNeuro...