A5009909096- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Immunotherapy and Immune Responses
- IL-33, ST2, and ILC Pathways
- Cancer Immunotherapy and Biomarkers
- CAR-T cell therapy research
- Sirtuins and Resveratrol in Medicine
- Cytokine Signaling Pathways and Interactions
- FOXO transcription factor regulation
- Spectroscopy and Laser Applications
- Advanced Chemical Sensor Technologies
- Psoriasis: Treatment and Pathogenesis
- Dermatology and Skin Diseases
- Cancer therapeutics and mechanisms
- Cancer Genomics and Diagnostics
- Endoplasmic Reticulum Stress and Disease
- Chemokine receptors and signaling
- Peptidase Inhibition and Analysis
- interferon and immune responses
- Adipose Tissue and Metabolism
- Traditional Chinese Medicine Analysis
- Transgenic Plants and Applications
- Cell death mechanisms and regulation
- Autophagy in Disease and Therapy
- Nuclear Receptors and Signaling
Tsinghua University
2018-2025
Nanchang University
2024
Moffitt Cancer Center
2023
Zhejiang A & F University
2021-2022
82th Hospital of Pla
2021
Fudan University Shanghai Cancer Center
2020
The First Affiliated Hospital, Sun Yat-sen University
2014
Sun Yat-sen University
2014
Nankai University
2009
University of Alaska Fairbanks
1995-1996
In cancer, persistent antigens drive CD8+ T cell differentiation into exhausted progenitor (Texprog) and terminally (Texterm) cells. However, how the extrinsic intrinsic regulatory mechanisms cooperate during this process still remains not well understood. Here, we found that STAT3 signaling plays essential roles in promoting intratumor Texterm development by enhancing their effector functions survival, which results better tumor control. microenvironments, is predominantly activated IL-10...
T helper 17 (TH17) cells and interleukin-17A (IL-17A) produced by them are critical in autoinflammatory diseases, such as psoriasis. IL-17A has been shown to signal through IL-17 receptor A/IL-17 C (IL-17RA/IL-17RC) complex drive inflammatory responses. However, a psoriasis model, we found that Il17rc deficiency did not completely ameliorate the disease, suggesting another receptor. In search for IL-17A-interacting receptor, IL-17RD directly bound but IL-17F or IL-17A/F heterodimer formed...
The exact mechanism of the protective role Resveratrol (Res) in lipid metabolism and oxidative stress is not well elucidated. present study aimed to investigate potential benefits possible mechanisms Res on amelioration hepatic steatosis a KKAy mouse model.A total 30 male mice were randomly divided into three groups: normal chow group, low resveratrol group high group. After 12-wk period, serum levels TG, TC, LDL-C HDL-C, liver content TG ROS, GSH, GPx, SOD MDA measured. Ectopic deposition...
Overcoming CD8+ T cell exhaustion is critical in cancer immunotherapy. Recently, an intratumor stem/progenitor-like (Tprog cell) population that mediates the persistence of antitumor responses has been defined, which can further develop into a terminally differentiated (Tterm subpopulation with potent cytotoxic functions. Tprog cells are main responders to immune checkpoint blockade therapies, yet how extrinsic signals via transcription factors control generation and tumors unclear. Here, we...
RORγt is the lineage-specific transcription factor for T helper 17 (T H 17) cells and an attractive drug target treating 17-associated diseases. Although critical role of in early cell differentiation has been well recognized, its function mature maintenance remains largely unknown. Here, we show that genetic deletion Rorc inhibited their pathogenic functions. Mechanistically, loss led to a closed chromatin configuration at key 17-specific gene loci, particularly “super-enhancer” regions....
TCRαβ
CD8
T cell activation is accompanied by extensive changes in epigenome. However, the high-ordered chromatin organization underpinning CD8+ not fully known. Here, we show three-dimensional genome during activation, associated with gene transcription. We that T-cell-specific deletion of Trim28 mice disrupts autocrine IL-2 production and leads to impaired vitro vivo. Mechanistically, TRIM28 binds regulatory regions genes formation chromosomal loops activation. At loop anchor regions,...
Regulatory T (Treg) cells are known to impede antitumor immunity, yet the regulatory mechanisms and functional roles of these remain poorly understood. In this study, through characterization multiple cancer models, we identified a substantial presence peripherally induced Treg in tumor microenvironment (TME). Depletion triggered responses provided potent therapeutic effects by increasing CD8+ cells. Fate-mapping transfer experiments revealed that IFN-γ-expressing helper (Th) 1...
<title>Abstract</title> <bold>Objective:</bold> To investigate the temporal changes in AQP4 polarity and pericyte vascularity during pathological progression of epilepsy, with goal identifying potential drug targets or regulatory strategies to delay epilepsy inhibit its onset. <bold>Methods:</bold> A rat model chronic was established via intraperitoneal injection pilocarpine. The vascular coverage pericytes were assessed using immunofluorescence. effects pharmacological modulation...
Inflammatory bowel disease (IBD) is multi-factorial chronic intestinal inflammation driven by pathogenic T cells, among which a large portion of patients are resistant to current anti-inflammatory regimes. The mechanisms underlying colitis pathogenicity and drug resistance not fully understood. Here, we demonstrate that RORα highly expressed in active UC patients, particularly those non-responsive anti-TNF treatment. Rorα deficiency CD4+ cells greatly reduced development. Mechanistically,...
Innate lymphoid cells (ILC) are similar to T helper (Th) in expression of cytokines and transcription factors. For example, RORγt is the lineage-specific factor for both ILC3 Th17 cells. However, ILC counterpart BCL6-expressing follicular (Tfh) has not been defined. Here, we report that compartment, BCL6 selectively co-expressed with only CXCR5 but also CCR6 from multiple tissues. BCL6-deficient produces enhanced levels IL-17A IL-22. More importantly, phenotypic single-cell ATAC-seq analysis...
T follicular helper (Tfh) cells, essential for germinal center reactions, are not identical, with different phenotypes reported. Whether, when, and how they generate memory cells is still poorly understood. Here, through single-cell RNA-sequencing analysis of CXCR5+Bcl6+ Tfh generated under conditions, we discovered, in addition to PD-1hi effector a CD62L+PD1low subpopulation. CD62L-expressing developed independently from PD-1+ direct contact B cells. More importantly, CD62L+ expressed...
Transforming growth factor-β is well known to restrain cytotoxic T cell responses maintain self-tolerance and promote tumor immune evasion. In this study, we have investigated the role of SMAD4, a core component in TGF-β signaling pathway, CD8+ cells. Unexpectedly, found that SMAD4 was critical promoting function both infection models. SMAD4-mediated transcriptional regulation activation cytotoxicity dependent on receptor (TCR) but not pathway. Following TCR activation, translocated into...
Forkhead box O transcriptional factors, especially FoxO1 and FoxO3a, play critical roles in physiologic pathologic immune responses. However, the function of FoxO4, another main member FoxO family, lymphoid cells is still poorly understood. Here, we showed that loss FoxO4 T augmented IFN-γ production Th1 vitro. Correspondingly, conditional deletion CD4+ enhanced cell-specific responses to Listeria monocytogenes infection vivo. Genome-wide occupancy transcriptomic analyses identified Dkk3...