A5101950062- Immune Cell Function and Interaction
- Environmental Toxicology and Ecotoxicology
- Immunotherapy and Immune Responses
- T-cell and B-cell Immunology
- Listeria monocytogenes in Food Safety
- CAR-T cell therapy research
- Pesticide and Herbicide Environmental Studies
- Diverse Topics in Contemporary Research
- Insect and Pesticide Research
- Microbial Inactivation Methods
- Cancer Immunotherapy and Biomarkers
- Insect Pest Control Strategies
- Aquatic Ecosystems and Phytoplankton Dynamics
- Educational Systems and Policies
- Food Safety and Hygiene
- Diverse Approaches in Healthcare and Education Studies
- Mosquito-borne diseases and control
- Water Quality and Pollution Assessment
- Effects and risks of endocrine disrupting chemicals
- Fish Ecology and Management Studies
- Pesticide Residue Analysis and Safety
- Viral gastroenteritis research and epidemiology
- Cancer Research and Treatments
- IL-33, ST2, and ILC Pathways
- Psoriasis: Treatment and Pathogenesis
Incheon National University
2020-2024
Seoul National University
2007-2023
The University of Texas MD Anderson Cancer Center
2012-2022
Rural Development Administration
2004-2021
Dongguk University
2015
National Academy of Agricultural Science
2011-2012
Gyeongsang National University
2012
National Institute of Agricultural Science and Technology
2004-2010
National Institute of Food and Drug Safety Evaluation
2006
Abstract During cancer immunoediting, loss of major histocompatibility complex class I (MHC-I) in neoplasm contributes to the evasion tumours from host immune system. Recent studies have demonstrated that most natural killer (NK) cells are found advanced cancers defective, releasing malignant MHC-I-deficient NK-cell-dependent control. Here, we show a T (NKT)-cell-ligand-loaded tumour-antigen expressing antigen-presenting cell (APC)-based vaccine effectively eradicates these tumours. this...
Studies over the last 2 decades have identified IL-17 and IL-21 as key cytokines in modulation of a wide range immune responses. serves critical defender against bacterial fungal pathogens, while maintaining symbiotic relationships with commensal microbiota. However, alterations its levels can lead to chronic inflammation autoimmunity. IL-21, on other hand, bridges adaptive innate responses, imbalance is implicated autoimmune diseases cancer, highlighting important role both health disease....
The larvicidal activity of 11 Myrtaceae essential oils and their constituents was evaluated against Aedes aegypti L. Of the 11, Melaleuca linariifolia Sm., dissitiflora F. Muell., quinquenervia (Cav.) S. T. Blake, Eucalyptus globulus Labill at 0.1 mg/ml exhibited ≥80% larval mortality. At this same concentration, individual tested, allyl isothiocyanate, α-terpinene, p-cymene, (+)-limonene, (−)-limonene, γ-terpinene, (E)-nerolidol, resulted in ≥95% We also tested acute toxicity these four...
The molecular mechanisms that govern differential T cell development into pro-inflammatory Th17 vs. regulatory (Treg) cells remain unclear. Here, we show selective deletion of CREB in or impaired differentiation vitro and vivo, led to resistance autoimmune diseases. Mechanistically, CREB, activated by CD3-PKC-ϴ signaling, plays a key role regulating differentiation, at least part through directly binding the Il17-Il17f gene locus. Unexpectedly, although dispensable for FOXP3 expression...
To demonstrate potent efficacy, a cancer vaccine needs to activate both innate and adaptive immune cells. Personalized strategies often require the identification of patient-specific neoantigens; however, clonal mutational heterogeneity cells presents inherent challenges. Here, extracellular nanovesicles derived from alpha-galactosylceramide-conjugated autologous acute myeloid leukemia (AML) (ECNV-αGC) are presented as personalized therapeutic that activates responses, bypassing need...
Abstract Pathogenic conversion of Th17 cells into multifunctional helper T or Th1 contributes to the pathogenesis autoimmune diseases; however, mechanism regulating plasticity remains unclear. Here, we found that expressed latent TGF-β1 in a manner dependent on autocrine TGF-β1. By employing IL-17-producing cell-specific Tgfb1 conditional knockout and fate-mapping systems, demonstrated TGF-β1-deficient are relatively susceptible becoming IFN-γ producers through IL-12Rβ2 IL-27Rα upregulation....
GM-CSF as an adjuvant has been shown to promote antitumor immunity in mice and humans; however, the underlying mechanism of GM-CSF-induced remains incompletely understood. In this study, we demonstrate that potentiates efficacy cancer vaccines through IL9-producing Th (Th9) cells. selectively enhanced Th9 cell differentiation by regulating COX2-PGE2 pathway while inhibiting induced regulatory T (iTreg) cells vitro vivo GM-CSF-activated monocyte-derived dendritic converted tumor-specific...
Abstract The repellency of fennel ( Foeniculum vulgare Miller)‐containing products (5% aerosol and 8% cream) against mosquitoes was compared with those citronella oil, geranium oil deet, as well three commercial repellents, Baby Keeper ® cream containing IR3535, MeiMei oils, Repellan S 19% N , ‐diethyl‐ m ‐toluamide (deet) under laboratory field conditions. In a study female Aedes aegypti (L), exhibited good in release‐in‐cage test skin patch tests the comparable oils. paddy five human...
BACKGROUND:This study was carried out to investigate pesticide residues from fifty streams in Korea.Water samples were collected at two times.Thee first sampling performed april may, which the season for start of application and second event august september, a period spraying pesticides multiple times. METHODS AND RESULTS:The 136 analyzed by LC-MS/MS GC/ECD.As result, eleven detected sampling.Twenty eight sampling.Seven frequently more than 10 water samples.Ecological risk assessment (ERA)...
This study provides a review of methods used in the determination organochlorine pesticides (OCPs) ginseng and compares effectiveness three extraction (Quick, Easy, Cheap, Effective, Rugged, Safe (QuEChERS), modified QuEChERS Fast Pesticide Extraction (FaPEx)) analyses 20 OCPs root samples. For each method, sample mass, solvent volume sorbent mass were varied to identify optimum combination effectively isolate analytes interest from complex matrix. Extracts analyzed using gas...
Forkhead box O transcriptional factors, especially FoxO1 and FoxO3a, play critical roles in physiologic pathologic immune responses. However, the function of FoxO4, another main member FoxO family, lymphoid cells is still poorly understood. Here, we showed that loss FoxO4 T augmented IFN-γ production Th1 vitro. Correspondingly, conditional deletion CD4+ enhanced cell-specific responses to Listeria monocytogenes infection vivo. Genome-wide occupancy transcriptomic analyses identified Dkk3...
Global spreading of SARS-CoV-2 Omicron subvariants, such as BA.4, BA.5, and XBB.1.5, has been leading the recent wave COVID-19. Unique mutations in spike proteins these emerging subvariants caused immune evasion from pre-existing protective immunity induced by vaccination or natural infection. We previously developed AdCLD-CoV19-1, a non-replicating recombinant adenoviral vector that encode receptor binding domain protein ancestral strain. Based on same platform, we constructed updated...
Transforming growth factor beta 1 (TGF-β1) is an immunosuppresive cytokine that plays essential role in immune homeostasis. It well known regulatory T (Treg) cells express TGF-β1; however, the of autocrine TGF-β1 development, function, and stability Treg remains poorly understood. We found cell-derived was not required for development thymic mice, but played a expression latency-associated peptide optimal suppression naïve cell proliferation vitro. Moreover, frequency significantly reduced...
In the spleen, exogenous antigen is preferentially presented by CD8alpha+CD11b- DC to CD8 T cells and CD8alpha-CD11b+ CD4 cells. However, it not yet clear whether same rule applies other secondary lymphoid organs. To address this issue, we first classified tissues into three categories based on expression pattern of CD8alpha CD11b in C57BL/6 BALB/c mice: (a) (b) mesenteric lymph node (MLN) (c) peripheral nodes (PLN). We then analyzed OVA-specific cell-stimulating capacity each subset after...
Although treatment with the glucocorticoid-induced tumor necrosis factor receptor-related protein (GITR) agonistic antibody (DTA-1) has shown antitumor activity in various models, underlying mechanism is not fully understood. Here, we demonstrate that interleukin (IL)-21-producing follicular helper T (Tfh) cells play a crucial role DTA-1-induced inhibition. The administration of DTA-1 increased IL21 expression by Tfh an antigen-specific manner, and this activation led to enhanced cytotoxic...
본 연구는 들깻잎의 미생물 안전성을 확보하기 위하여 전해수의 세척 효과를 검정하고 아울러 전해수와 유기산, 초음파 병용처리의 검토하였다. 병용처리할 유기산을 선정하기 acetic acid, citric maleic acid를 전해수 100 ppm에 2%씩 첨가하고 약 8.0 log CFU/mL 의 S. Typhimurium, B. cereus, aureus와 반응시켰다. 세 유기산 중 acid의 상승효과가 가장 높아 첨가 농도별 저해 분석하고자 0.5, 1.0, 1.5, 2.0%씩 ppm 전해수에 배양액과 들깻잎표면에서 식중독세균 저감효과를 분석하였다. (25 KHz), 전해수, 0.5% 초음파를 병용처리를 하였다. 종류의 탁월하였고, Typhimurium은 농도가 증가할수록 저감효과도 높아졌으며 2.0% 첨가시 1.0 <TEX>$log_{10}$</TEX> CFU/g의 관찰되었다. aureus는 단독처리(2.08 CFU/g감소)에 비하여 1.5%까지는 없었지만 결합처리에서...
The seroprevalence of hepatitis E virus (HEV) among high-risk groups overseas is high, but studies in these are rare South Korea. We conducted the present study from April to November 2012 obtain data on and associated risk factors for HEV slaughterhouse workers Korea.Slaughterhouse 80 workplaces nationwide were surveyed Korea 2012. subjects comprised 1848 cases: 1434 slaughter 414 residual products handlers. By visiting slaughterhouses, which mixed with 75 also performed handling, we a...
본 연구는 들깻잎과 들깻잎 생산환경을 대상으로 276개의 시료를 채취하여 B. cereus를 분리 하였다. 분리된 cereus 200주의 toxicity를 평가하고자 독소유전자와 항생제내성을 검색하였다. 그 결과 균주에서 11개의 서로 다른 독소유전자 패턴은 확인하였으며 5개의 설사형독소와 구토형 독소를 모두 생성할 수 있는 균주는 21%였다. 가장 빈번하게 검출되는 독소유전자는 nheA(100%), enFM(100%), hblA, C, D(66.5%)였으며 EM은 낮은 빈도(21.0%)로 검출되었다. 항생제 내성평가결과 대부분의 cereus는 18종의 중 10개의 항생제에 대해서는 감수성이었으나 <TEX>${\beta}$</TEX>-lactam계 항생제인 penicillin(100%), ampicillin(100%), oxacillin(94.9%), amoxicillin-clavulanic acid(95.6%), cefazolin(78.2%)과...