A5100778649- RNA modifications and cancer
- RNA Research and Splicing
- Bioinformatics and Genomic Networks
- Epigenetics and DNA Methylation
- Cancer Genomics and Diagnostics
- Cancer-related molecular mechanisms research
- RNA and protein synthesis mechanisms
- Molecular Biology Techniques and Applications
- Genetic Associations and Epidemiology
- Immune Response and Inflammation
- Gene expression and cancer classification
- Cancer-related gene regulation
- Genetics, Bioinformatics, and Biomedical Research
- Cell Adhesion Molecules Research
- Chemokine receptors and signaling
- Hepatocellular Carcinoma Treatment and Prognosis
- Monoclonal and Polyclonal Antibodies Research
- MicroRNA in disease regulation
- Liver Disease Diagnosis and Treatment
- Immune cells in cancer
- Cancer Immunotherapy and Biomarkers
- Immunotherapy and Immune Responses
- Cytokine Signaling Pathways and Interactions
- Context-Aware Activity Recognition Systems
- Genetic factors in colorectal cancer
Seoul National University
2022-2025
Ajou University Hospital
2011-2024
Jeonbuk National University
2011-2024
New Generation University College
2024
The University of Texas MD Anderson Cancer Center
2018-2023
University of Utah
2017-2023
Chungbuk National University
2009-2023
Hallym University
2023
Huntsman Cancer Institute
2018-2021
Korea Advanced Institute of Science and Technology
2015-2019
Background Cancer staging and treatment presumes a division into localized or metastatic disease. We proposed an intermediate state defined by ≤5 cumulative metastasis(es), termed oligometastases. In contrast to widespread polymetastases, oligometastatic patients may benefit from metastasis-directed local treatments. However, many who initially present with oligometastases progress polymetastases. Predictors of progression could improve patient selection for therapy. Methods Here, we...
Abstract Neoadjuvant ipilimumab + nivolumab (Ipi+Nivo) and chemotherapy (Nivo+CT) induce greater pathologic response rates than CT alone in patients with operable non-small cell lung cancer (NSCLC). The impact of adding to neoadjuvant Nivo+CT is unknown. Here we report the results correlates two arms phase 2 platform NEOSTAR trial testing Ipi+Nivo+CT major (MPR) as primary endpoint. MPR were 32.1% (7/22, 80% confidence interval (CI) 18.7–43.1%) arm 50% (11/22, CI 34.6–61.1%) arm; endpoint...
The receptor tyrosine kinase Flt3 plays an important role in proliferation and survival of hematopoietic stem progenitor cells. Although some post-receptor signaling events have been characterized, the involvement Janus kinase/signal transducer activator transcription (Jak/Stat) pathway has not thoroughly evaluated. To this aim, we examined whether activates Jak/Stat Baf3/Flt3 cells, a line stably expressing human receptor. Stat5a, but Stats 1–4, 5b, or 6, was potently activated by ligand...
Stromal cell-derived factor-1 (SDF-1/CXCL12) enhances survival of myeloid progenitor cells. The two main questions addressed by us were whether these effects on the progenitors direct-acting and if SDF-1/CXCL12 enhanced engrafting capability competitive, repopulating mouse stem cells subjected to short-term ex vivo culture with other growth factors. had survival-enhancing/antiapoptosis human bone marrow (BM) cord blood (CB) BM colony-forming units (CFU)-granulocyte macrophage, burst-forming...
Due to the large number of putative microRNA gene targets predicted by sequence-alignment databases and relative low accuracy such predictions which are conducted independently biological context design, systematic experimental identification validation every functional target is currently challenging. Consequently, studies have yet identify, on a genome scale, key regulatory networks perturbed altered functions in cancer. In this report, we demonstrate for first time how phenotypic...
Hemopoiesis is regulated in part by survival/apoptosis of hemopoietic stem/progenitor cells. Exogenously added stromal cell-derived factor-1 ((SDF-1)/CXC chemokine ligand (CXCL)12) enhances survival/antiapoptosis myeloid progenitor cells vitro. To further evaluate SDF-1/CXCL12 effects on cell survival, transgenic mice endogenously expressing under a Rous sarcoma virus promoter were produced. Myeloid progenitors (CFU-granulocyte-macrophage, burst-forming unit-erythroid,...
We report on the first case of human babesiosis in Korea. The intraerythrocytic parasite (KO1) patient's blood mainly appeared as paired pyriforms and ring forms; but Maltese cross forms were not seen, showed morphological features consistent with those genus Babesia sensu stricto. sequence 18S rRNA gene KO1 was closely related to that spp. isolated from sheep China (similarity, 98%). present study provides evidence presence a hitherto unidentified, new type capable infecting humans.
One of the fundamental challenges in cancer is to detect regulators gene expression changes during progression. Through transcriptional silencing critical cancer-related genes, epigenetic change such as DNA methylation plays a crucial role cancer. In addition, miRNA, another major component epigenome, also regulator at post-transcriptional levels that modulate transcriptome changes. However, mechanistic synergistic interactions between and miRNA on transcriptomic its association with...
Background Monotherapy with immune checkpoint blockade is ineffective for patients (pts) microsatellite stable (MSS) metastatic colorectal cancer (mCRC). This study investigates whether the combination of trametinib (T) durvalumab (D) can alter tumor microenvironment (TME) by successfully priming and activating T-cells. Methods Open-label, single-center, phase II trial primary endpoint immune-related response rate T+D in refractory MSS mCRC pts ( NCT03428126 ). T 2 mg/day orally starting 1...
Abstract Background TREM2 is a transmembrane receptor expressed by myeloid cells and acts to regulate their immune response. governs the response of microglia amyloid tau pathologies in Alzheimer’s disease (AD) brain. also present soluble form (sTREM2), its CSF levels fluctuate as function AD progression. Analysis stroke mouse models revealed that sTREM2 proteins bind neurons, which suggests may act non-cell autonomous manner influence neuronal function. arises from proteolytic cleavage...
Background: Mucin1 (MUC1) is a highly glycosylated transmembrane protein that has gained attention because of its overexpression in various cancers. However, MUC1-targeted therapeutic antibodies have not yet been approved for cancer therapy. MUC1 cleaved to two subunits, MUC1-N and MCU1-C. released from the cell surface, making MUC1-C more reasonable target Therefore, we produced monoclonal antibody (anti-hMUC1) specific extracellular region evaluated effects vitro vivo. Methods: We using...
Epithelial-to-mesenchymal transition (EMT) underlies immunosuppression, drug resistance, and metastasis in epithelial malignancies. However, the way which EMT orchestrates disparate biological processes remains unclear. Here, we identify an EMT-activated vesicular trafficking network that coordinates promigratory focal adhesion dynamics with immunosuppressive secretory program lung adenocarcinoma (LUAD). The EMT-activating transcription factor ZEB1 drives exocytotic by relieving Rab6A,...
A mechanistic understanding of the biological and technical factors that impact transcript measurements is essential to designing analyzing single-cell single-nucleus RNA sequencing experiments. Nuclei contain same pre-mRNA population as cells, but they a small subset mRNAs. Nonetheless, early studies argued analysis yielded results comparable cellular samples if were included. However, typical workflows do not distinguish between mRNA when estimating gene expression, variation in their...
DNA variants that affect alternative splicing and the relative quantities of different gene transcripts have been shown to be risk alleles for some Mendelian diseases. However, complex traits characterized by a low odds ratio any single contributing variant, very few studies investigated contribution variants. The overarching goal this study is discover characterize role affecting may play in genetic etiology traits, which include significant number common human Specifically, we hypothesize...
Alzheimer's disease (AD) presents a significant public health problem and major cause of dementia. Not only genetic but epigenetic factors contribute to complex heterogeneous molecular mechanisms underlying AD risk; in particular, single nucleotide polymorphisms (SNPs) DNA methylation can lead dysregulation gene expression the brain. Each these regulators has been independently studied well progression, however, their interactive roles, particularly when they are located differently, still...
Characterizing the biomolecular systems' properties underpinning prognosis signatures derived from gene expression profiles remains a key clinical and biological challenge. In breast cancer, while different "poor-prognosis" sets of genes have predicted patient survival outcome equally well in independent cohorts, these prognostic surprisingly little genetic overlap. We examine 10 such published expression-based that are predictors or distinct cancer phenotypes, uncover their mechanistic...
Abstract Summary: GO-Module is a web-accessible synthesis and visualization tool developed for end-user biologists to greatly simplify the interpretation of prioritized Gene Ontology (GO) terms. radically reduces complexity raw GO results into compact biomodules in two distinct ways, by (i) constructing from significant terms based on hierarchical knowledge, (ii) refining each biomodule contain only true positive results. Altogether, features (biomodules) outputs are better organized average...
While genome-wide association studies (GWAS) of complex traits have revealed thousands reproducible genetic associations to date, these loci collectively confer very little the heritability their respective diseases and, in general, contributed our understanding underlying disease biology. Physical protein interactions been utilized increase human Mendelian but yet be fully exploited for traits.We hypothesized that interaction modeling GWAS findings could highlight important...
Thousands of complex-disease single-nucleotide polymorphisms (SNPs) have been discovered in genome-wide association studies (GWAS). However, these intragenic SNPs not collectively mined to unveil the genetic architecture between complex clinical traits. The authors hypothesize that biological annotations host genes trait-associated may reveal biomolecular modularity across traits and offer insights for drug repositioning.Trait-to-polymorphism associations confirmed GWAS were used. A novel...
The cytomegalovirus immediate‐early (CMV IE) gene enhancer/promoter regulates the expression of products and initiation CMV replication. TNF‐α lipopolysaccharide (LPS) strongly activate promoter, possibly involving NF‐κB. CpG‐oligodeoxynucleotides (CpG‐ODNs), which contain unmethylated CpG dinucleotides in context particular base sequences, have gained attention because their stimulating effects, via NF‐κB, a strong innate immune response. To study effects LPS CpG‐ODNs, as well mechanisms...