A5022039054- Infant Nutrition and Health
- Cancer Immunotherapy and Biomarkers
- Immunotherapy and Immune Responses
- Viral gastroenteritis research and epidemiology
- Neonatal Respiratory Health Research
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Gut microbiota and health
- Lung Cancer Diagnosis and Treatment
- Clostridium difficile and Clostridium perfringens research
- Clinical Nutrition and Gastroenterology
- Hepatocellular Carcinoma Treatment and Prognosis
- Hepatitis Viruses Studies and Epidemiology
- Radiomics and Machine Learning in Medical Imaging
- Neonatal and Maternal Infections
- Ferroptosis and cancer prognosis
- SARS-CoV-2 detection and testing
- Lung Cancer Treatments and Mutations
- Immune Cell Function and Interaction
- Dialysis and Renal Disease Management
- Prostate Cancer Treatment and Research
- Immune cells in cancer
- Viral Infections and Immunology Research
- Child Nutrition and Water Access
- Photonic and Optical Devices
Shanghai Chest Hospital
2025
Chinese PLA General Hospital
2023-2025
Changhai Hospital
2024
Second Military Medical University
2024
University of Copenhagen
2017-2023
Jilin University
2019-2023
Ruijin Hospital
2023
Shanghai Jiao Tong University
2023
First Affiliated Hospital of Guangzhou Medical University
2021-2023
State Key Laboratory of Respiratory Disease
2021-2023
Objective Patients with renal failure suffer from symptoms caused by uraemic toxins, possibly of gut microbial origin, as deduced studies in animals. The aim the study is to characterise relationships between intestinal microbiome composition, toxins and human end-stage disease (ESRD). Design Characterisation microbiome, serum faecal metabolome phenotypes a cohort 223 patients ESRD 69 healthy controls. Multidimensional data integration reveal links these datasets use chronic kidney (CKD)...
Abstract The gut microbiota (GM) is related to obesity and other metabolic diseases. To detect GM markers for in patients with different abnormalities investigate their relationships clinical indicators, 1,914 Chinese adults were enrolled 16S rRNA gene sequencing this retrospective study. Based on composition, Random forest classifiers constructed screen the (Group OA) or without diseases O) from healthy individuals H), high accuracies observed discrimination of Group O OA (areas under...
Hepatocellular carcinoma has high recurrence rates after surgery; however, there are no approved standard-of-care neoadjuvant or adjuvant therapies. Immunotherapy been shown to improve survival in advanced hepatocellular carcinoma; we therefore aimed evaluate the safety and tolerability of perioperative immunotherapy resectable carcinoma.
Abstract Neoadjuvant ipilimumab + nivolumab (Ipi+Nivo) and chemotherapy (Nivo+CT) induce greater pathologic response rates than CT alone in patients with operable non-small cell lung cancer (NSCLC). The impact of adding to neoadjuvant Nivo+CT is unknown. Here we report the results correlates two arms phase 2 platform NEOSTAR trial testing Ipi+Nivo+CT major (MPR) as primary endpoint. MPR were 32.1% (7/22, 80% confidence interval (CI) 18.7–43.1%) arm 50% (11/22, CI 34.6–61.1%) arm; endpoint...
The spread of the novel SARS-Cov-2 variant Omicron created a challenging public health situation in number countries. In March 2022, emerged Changchun, China, and patients infected rapidly increased. prevalence infection symptoms differs from that Delta, with more upper airway clinical apparent. This study aimed to investigate characteristics variant.In this retrospective study, we collected data participants Changchun who had tested positive for quantitative polymerase chain reaction...
Abstract Background Fortification of donor human milk (DHM) is required for optimal growth very preterm infants, but there are concerns more gut dysfunction and necrotizing enterocolitis (NEC) when using formula‐based fortifiers (FFs), especially soon after birth. Intact bovine colostrum (BC) rich in nutrients bioactive factors, protects against NEC pigs. We hypothesized that fortification DHM with BC superior to FFs prevent infections provided shortly Methods Two FF products, Enfamil (ENF;...
Preterm infants are highly susceptible to late-onset sepsis (LOS) and necrotizing enterocolitis (NEC), but disease pathogenesis specific diagnostic markers lacking. Circulating cell-free DNA (cfDNA) immune cell-derived proteins involved in multiple diseases adults have not been investigated preterm neonates. We explored the relation of circulating neutrophil-associated cfDNA LOS and/or NEC. Using a clinically relevant pig model spontaneous NEC development, we plasma, together with cytokines...
Necrotizing enterocolitis (NEC) is an acute gut inflammatory disorder that occurs in preterm infants the first weeks after birth. Infants surviving NEC often show impaired neurodevelopment. The mechanisms linking lesions with later neurodevelopment are poorly understood but may include proinflammatory signaling immature brain. Using pigs as a model for infants, we hypothesized severe intestinal associated effects on developing hippocampus.Cesarean-delivered (n = 117) were reared 8 days and...
Cathepsin L (CTSL), a cysteine protease that can cleave and activate the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein, could be promising therapeutic target for disease 2019 (COVID-19). However, there is still no clinically available CTSL inhibitor used. Here, we applied Chemprop, newly trained directed-message passing deep neural network approach, to identify small molecules FDA-approved drugs block activity expand discovery of inhibitors drug development...
Highlights•apCAFs are associated with unfavorable outcomes in NSCLC patients receiving NCIT•apCAFs' expansion is triggered by IFN-γ via the JAK1/2-STAT1 pathway•apCAFs promote formation of FOXP1+Tregs through PD-L2-RGMB axis•Targeting apCAFs blockade axis improves immunotherapy efficacySummaryConventional neoadjuvant chemotherapy provides limited benefit for resectable non-small cell lung cancer (NSCLC). Recently, chemoimmunotherapy (NCIT) has transformed perioperative management priming...
Abstract Purpose It has been shown that abnormalities of coagulation and fibrinolysis system are involved in the pathogenesis necrotizing enterocolitis (NEC), but not well studied challenge context early detection disease progression. The present study mainly explores predictive significance parameters at time NEC diagnosis identifying patients who eventually received surgery and/or NEC-related deaths. Methods retrospective 114 neonates with was conducted assessments demographic data,...
Emerging evidence is examining the precise role of intestinal microbiota in pathogenesis type 2 diabetes. The aim this study was to investigate association and microbiota-generated metabolites with glucose metabolism systematically a large cross-sectional China. 1160 subjects were divided into three groups based on their level: normal group (n=504), prediabetes (n=394), diabetes (n=262). Plasma concentrations TMAO, choline, betaine, carnitine measured. Intestinal measured subgroup 161...
Abstract Background The prevalence of idiopathic membranous nephropathy (IMN) is increasing worldwide and the gut microbiota recognized to play a role in its pathology. aim this study was understand involvement gut–kidney axis IMN by analyzing composition biopsy-proven patients compared with healthy controls (HC). Methods Fecal samples from 30 diagnosed renal biopsy co-residents (control group) were collected for analysis Nephrology Department Second Affiliated Hospital Harbin Medical...
Ready-to-feed liquid infant formula is increasingly used for preterm infants when human milk unavailable. These formulas are sterilized by ultra-high temperature treatment, but heating and storage may reduce bioactivity increase formation of Maillard reaction products with potential negative consequences immature newborns.
Background: Apatinib is a tyrosine kinase inhibitor (TKI) that selectively inhibits the vascular endothelial growth factor receptor-2. A weighted pooled analysis was performed to evaluate clinical outcome, efficacy, and toxicity of apatinib in patients with advanced nonsmall cell lung cancer (NSCLC) failed prior treatment chemotherapy or epidermal receptor-TKIs (EGFR-TKIs). Methods: The literature published PubMed, Embase, Cochrane Library databases searched (from inception November 30,...
Abstract Persistent asymptomatic (PA) SARS-CoV-2 infections have been identified. The immune responses in these patients are unclear, and the development of effective treatments for is needed. Here, we report a cohort 23 PA cases carrying viral RNA up to 191 days. displayed low levels inflammatory interferon response, weak antibody diminished circulating follicular helper T cells (cTfh), inadequate specific CD4 + CD8 T-cell during infection, which distinct from symptomatic resembling...
The development of immunotherapy resistance is associated with a poor prognosis in patients diagnosed hepatocellular carcinoma (HCC) who are undergoing treatment immune checkpoint inhibitors (ICI). This study aimed to evaluate the efficacy and safety subsequent radiotherapy (RT) for advanced-stage HCC had lesion enlargement or new lesions (NLs) during ICI therapy.This retrospective observational enrolled 36 underwent RT NLs therapy from two centers. primary endpoints were progression-free...