A5101906876- Infant Nutrition and Health
- Neonatal Respiratory Health Research
- Anesthesia and Sedative Agents
- Anesthesia and Neurotoxicity Research
- Congenital gastrointestinal and neural anomalies
- Esophageal and GI Pathology
- Congenital Diaphragmatic Hernia Studies
- Neonatal and Maternal Infections
- Appendicitis Diagnosis and Management
- Anesthesia and Pain Management
- Cardiac, Anesthesia and Surgical Outcomes
- Mechanical Circulatory Support Devices
- Organ Transplantation Techniques and Outcomes
- Pediatric Hepatobiliary Diseases and Treatments
- Traumatic Brain Injury and Neurovascular Disturbances
- Hernia repair and management
- Aortic Disease and Treatment Approaches
- Congenital Heart Disease Studies
- Intestinal Malrotation and Obstruction Disorders
- Central Venous Catheters and Hemodialysis
- Intensive Care Unit Cognitive Disorders
- Urological Disorders and Treatments
- Vascular Procedures and Complications
- Viral gastroenteritis research and epidemiology
- Asthma and respiratory diseases
Chongqing Medical University
2015-2025
China International Science and Technology Cooperation
2022-2025
Children's Hospital of Chongqing Medical University
2015-2025
Xiamen University
2024
National Clinical Research
2022
University of Virginia
2018
First Affiliated Hospital of Xi'an Jiaotong University
2018
Capital Medical University
2009-2017
Beijing Children’s Hospital
2017
Beijing Anzhen Hospital
2009-2015
Abstract Background The aim of this study is to examine the safety and distribution Ad-EGFP-MDR1, an adenovirus encoding human multidurg resistance gene (human MDR1), in mice colon carcinoma model. Methods After bone marrow cells (BMCs) were infected with they administered by intra marrow-bone transplantation (IBM-BMT). Total antibody serum neutralizing factor (SNF) determined. Biodistribution Ad-EGFP-MDR1 was detected situ hybridization immunohistochemistry. peripheral hematocyte white...
Cluster of differentiation 133 (CD133) is recognized as a stem cell marker for normal and cancerous tissues. Using culture real‑time fluorescent polymerase chain reaction, CD133 expression was analyzed in osteosarcoma tissue Saos‑2 lines. In addition, cancer cell‑related gene the line determined to explore mechanisms underlying tumorigenesis high drug resistance osteosarcoma. CD133+ cells were found be widely distributed various types tissue. Following culture, entered G2/M S cycle stages...
Abstract Purpose It has been shown that abnormalities of coagulation and fibrinolysis system are involved in the pathogenesis necrotizing enterocolitis (NEC), but not well studied challenge context early detection disease progression. The present study mainly explores predictive significance parameters at time NEC diagnosis identifying patients who eventually received surgery and/or NEC-related deaths. Methods retrospective 114 neonates with was conducted assessments demographic data,...
Introduction Anorectal malformation (ARM) and Hirschsprung disease (HSCR) are common congenital gastrointestinal defects, but their co-occurrence is rare. This retrospective study analyzed clinical characteristics of patients with ARM associated HSCR for early diagnosis treatment guidance to reduce the occurrence severe complications. Materials Methods A single-center cohort analysis from 2010 2024 identified 2341 1721 HSCR. The histopathologic assessment included hematoxylin eosin (H&E)...
Background Wiskott–Aldrich syndrome (WAS) and X‐linked thrombocytopenia (XLT) are caused by mutations of the WAS gene. The genotype–phenotype association XLT have not been fully elucidated. Here, we established largest database in China to further determine potential correlation between genotype phenotype long‐term outcome. Procedures We collected clinical data 81 WAS/XLT patients, analyzed gene at genomic DNA transcriptional/translational levels, quantified three different patterns protein...
Background Necrotizing enterocolitis (NEC) is the leading cause of neonatal gastrointestinal-related death, while etiology and pathogenesis are poorly understood. Methods The levels CCL3 in intestinal tissue from modeling mice patients were measured analyzed. HE staining, TUNEL, Annexin FCM used to assess pathological changes apoptosis epithelial cells. CCL3, CCR4, cytokines, tight junction protein ZO-1, apoptosis-related genes ERK1/2-NF-κB signaling pathway detected by ELISA, Q-PCR, Western...
Background: Although adenosine (ADO) has been shown to have beneficial effects against tissue injury after myocardial ischaemia, the controversy still remains regarding optimal timing, dose, temperature, method of ADO administration and duration exposure drug. This study investigates cardioprotective effect exogenous pretreatment as an adjunct 1 mmol l−1 cold (12 °C) blood cardioplegia during heart valve replacement surgery. Materials methods: Thirty patients with rheumatic disease...
The mechanism of lipid-mediated injury human glomerular mesangial cells (HMCs) remains unclear. We investigated the association between endoplasmic reticulum (ER) stress and in HMCs vitro potential efficacy a therapeutic approach targeting ER stress.Human were exposed to low-density lipoprotein (LDL) and/or interleukin-1β (IL-1β). For evaluation whether participates HMCs, pretreated with tunicamycin or treated sodium 4-phenylbutyrate (4-PBA).Incubation LDL + IL-1β significantly increased...
Summary Background and Aim Trigger thumb is a common hand disability in children primarily treated with open surgery. A conscious median nerve block can usually meet the requirements for trigger thumb‐releasing surgery adults; however, its effectiveness requires further clarification. The present study aims to demonstrate whether ultrasound‐guided lower forearm blockade viable option undergoing thumb. Methods prospective randomized was designed compare blocks guided by ultrasonography those...
Neonatal necrotizing enterocolitis (NEC) is a common intestinal disease that threatens the lives of newborns and characterized by ischemic necrosis small intestine colon. As early diagnosis NEC improves prognosis, identification new or complementary biomarkers great importance. In this study, we evaluate diagnostic value CCL3 in compare its effectiveness with other commonly used biomarkers, such as procalcitonin (PCT) C-reactive protein (CRP). Serum samples were collected from 64 patients 38...
Simultaneous kidney and pancreas transplant is the preferred treatment option for end-stage renal disease due to type 1 diabetic nephropathy. Vascular complications are detrimental graft survival can lead loss in early postoperative phase of transplantation. Generally, duplex Doppler ultrasound used vascular patency monitoring pancreatectomy followed by re-transplantation required majority cases. Recently, pancreatic salvage with non-operative management, including medical anticoagulation...
Rapid central venous catheterization is critical for the rescue and perioperative management of premature infants requiring surgery. Ultrasound-guided dynamic needle tip positioning (DNTP) has been widely used as a very effective technique, especially in paediatric vascular puncture catheterization. However, low-weight newborns, vein still poses greater difficulties paediatricians anaesthesiologists. This prospective randomized control study aimed to evaluate efficacy combined short-...