A5045108124- COVID-19 Clinical Research Studies
- Oral microbiology and periodontitis research
- Diabetic Foot Ulcer Assessment and Management
- Calpain Protease Function and Regulation
- Healthcare Policy and Management
- Gold and Silver Nanoparticles Synthesis and Applications
- SARS-CoV-2 and COVID-19 Research
- Healthcare Systems and Reforms
- Neurological Disorders and Treatments
- Primary Care and Health Outcomes
- Gestational Diabetes Research and Management
- Erythrocyte Function and Pathophysiology
- Tea Polyphenols and Effects
- Pancreatic function and diabetes
- Inflammasome and immune disorders
- Mental Health Treatment and Access
- Food Quality and Safety Studies
- Cancer-related molecular mechanisms research
- Adipokines, Inflammation, and Metabolic Diseases
- Schizophrenia research and treatment
- Supercapacitor Materials and Fabrication
- Lipid Membrane Structure and Behavior
- Covalent Organic Framework Applications
- Fermentation and Sensory Analysis
- Berberine and alkaloids research
Nantong University
2025
Beijing Tongren Hospital
2019-2024
Capital Medical University
2019-2024
National Institutes for Food and Drug Control
2024
Union Hospital
2024
Huazhong University of Science and Technology
2024
Beijing YouAn Hospital
2024
Yunnan University
2019-2024
Puer University
2019-2024
Shanghai Jiao Tong University
2023
To discover new drugs to combat COVID-19, an understanding of the molecular basis SARS-CoV-2 infection is urgently needed. Here, for first time, we report crucial role cathepsin L (CTSL) in patients with COVID-19. The circulating level CTSL was elevated after and positively correlated disease course severity. Correspondingly, pseudovirus increased expression human cells vitro ACE2 transgenic mice vivo, while overexpression, turn, enhanced cells. functionally cleaved spike protein virus...
The spike (S) protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an important target for vaccine and drug development. However, the rapid emergence variant strains with mutated S proteins has rendered many treatments ineffective. Cleavage by host proteases essential viral infection. Here, we discovered that contains two previously unidentified Cathepsin L (CTSL) cleavage sites (CS-1 CS-2). Both are highly conserved among all known SARS-CoV-2 variants. Our structural...
Coptis chinensis is an ancient Chinese herb treating diabetes in China for thousands of years. However, its underlying mechanism remains poorly understood. Here, we report the effects main active component, berberine (BBR), on stimulating insulin secretion. In mice with hyperglycemia induced by a high-fat diet, BBR significantly increases secretion and reduced blood glucose levels. global or pancreatic islet β-cell-specific Kcnh6 knockout, does not exert beneficial effects. directly binds...
Cathepsin L (CTSL), a cysteine protease that can cleave and activate the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein, could be promising therapeutic target for disease 2019 (COVID-19). However, there is still no clinically available CTSL inhibitor used. Here, we applied Chemprop, newly trained directed-message passing deep neural network approach, to identify small molecules FDA-approved drugs block activity expand discovery of inhibitors drug development...
Calcium phosphate crystals, as the main component of dentin and enamel, have been widely used for occlusion dentinal tubules. However, low bond strength poor sealing effect limit their clinical practicality. In this study, a collagen/calcium dual-affinitive peptide E8DS (EEEEEEEEDSpESpSpEEDR) nano-hydroxyapatite (nano-HAp) flocculi were developed to seal tubules reducing hypersensitivity, whereas peptides pre-applied improve adhesion occlusive hydroxyapatite coating on collagen matrix...
The aroma profile of sun-dried black tea (SBT) was identified by headspace solid-phase microextraction (HS-SPME) coupled with gas chromatography-mass spectrometry (GC-MS) and chromatography-olfactometry (GC-O). A total 37 scents were captured using the GC-O technique, 35 odor intensities ranging from 1.09 ± 1.93 to 9.91 0.29 identified. Twenty-one compounds further as key odor-active activity values (OAVs) greater than or equal one. These restructured their detected concentrations, selected...
Helicobacter pylori infection is associated with several extragastric conditions including dyslipidemia and metabolic syndrome. This study aimed to investigate additional parameters H. in a Chinese population.Using case-control approach we studied 617 subjects 13C-urea breath test (13C-UBT) values ≥10‰ who were defined as being positive for (cases), while sex age- matched 13C-UBT ≤1‰ negative (controls) Beijing Tongren Hospital from March 2016 May 2017. Biochemical serum bilirubin lipids...
A pristine, redox-active triphenylstibine based COF (Sb-COF) exhibits well-uniform nanostructures which could provide sufficient electron conduction pathways and minimize the ion transport lengths, making moieties readily accessible by electrolyte. The assembled Sb-COF//rGO thus provides an excellent energy density of 69 W h Kg-1.
The pandemic of 2019 coronavirus (SARS-CoV-2) disease (COVID-19) has imposed a severe public health burden worldwide. Most patients with COVID-19 were mild. Severe progressed rapidly to critical condition including acute respiratory distress syndrome (ARDS), multi-organ failure and even death. This study aims find early injury indicators blood glucose for predicting mortality COVID-19.Fasting (FBG) ≥7.0 mmol/L two times during hospitalization without history diabetes defined as new-onset...
SUMMARY To discover new drugs to combat coronavirus disease 2019 (COVID-19), an understanding of the molecular basis severe acute respiratory syndrome 2 (SARS-CoV-2) infection is urgently needed. Here, for first time, we report crucial role cathepsin L (CTSL) in patients with COVID-19. The circulating level CTSL was elevated and positively correlated course severity COVID-19 patients. Correspondingly, SARS-CoV-2 pseudovirus increased expression human cell lines ACE2 transgenic mice, while...
For high-precision biochemical sensing, surface-enhanced Raman spectroscopy (SERS) has been demonstrated to be a highly sensitive spectroscopic analytical method and Ag is considered the best material for SERS performance. Due high surface activity of nanoparticles, stability nanostructures, especially in moist environments, one key issues that need solved. A silica (SiO2) cladding nanoparticles (NPs) here sensitivity long-term when putted aqueous solution. The chemically inert, transparent,...
As a proof-of-concept study, Imi-cage and Phos-cage organic molecular cages (OMCs) containing the triphenylphosphine (TPP) moiety, nonclassic AIE luminogen (AIEgen), have been designed to demonstrate cage-confinement induced emission enhancement (CCIEE). Thanks confinement effect of OMCs, rigid exhibits much higher photoluminescence (PL) quantum yield (ΦPL) than open-shell Semicage small molecule TPP in both solution amorphous solid states. The could be further enhanced crystalline state...
Abstract Background Given the reliability of circRNAs in symbolizing cancer progression, this investigation was designed to expound involvement hsa_circ_0028007 regulating chemosensitivity nasopharyngeal carcinoma (NPC) cells. Methods Altogether, 241 pairs NPC tissues and para‐cancerous normal were collected identify NPC‐symbolic circRNAs, which have been screened by circRNA microarray advance. Expressions determined means real‐time polymerase chain reaction (PCR). Besides, human cell lines...
A Gram-reaction-negative, yellow-pigmented, non-spore-forming rod, aerobic, motile bacterium, designated SJY3T, was isolated from soil samples collected a Pu-erh tea cellar in Bolian estate Co. Ltd. Pu'er city, Yunnan, south-west China. Phylogenetic analysis based on 16S rRNA gene sequences showed that the isolate belonged to genus Massilia. The closest phylogenetic relative Massilia arenae CICC 24458T (99.5 %), followed by M. timonae CCUG45783T (97.9 oculi CCUG43427AT (97.8 and aurea DSM...
Aberrant expression of numerous long non‑coding RNAs (lncRNAs) has been reported to be associated with nasopharyngeal carcinoma (NPC). The present study aimed investigate the and function lncRNA differentiation antagonizing non‑protein coding RNA (DANCR) in NPC pathogenesis. Reverse transcription‑quantitative polymerase chain reaction results suggested that DANCR was significantly upregulated cells. Overexpression promoted 5‑8F cell proliferation migration, as detected by Cell Counting...
Introduction: Community-based services for psychosis are an important part of mental health in China.We analyzed community-based follow-up and treatment China 2019 to provide evidence policymaking delivering.Methods: Data from the National Information System Psychosis were used analyze usage information system registration, management, situation patients with compared results that 2018.Results: In 2019, 100% cities counties 6,230,157 registered.In there 5,944,724 registered (94.05%) under...