A5101976448- Spine and Intervertebral Disc Pathology
- Medical Imaging and Analysis
- Spinal Fractures and Fixation Techniques
- Musculoskeletal pain and rehabilitation
- Mesenchymal stem cell research
- Tendon Structure and Treatment
- Healthcare and Venom Research
- Scoliosis diagnosis and treatment
- Bone fractures and treatments
- Orthopedic Infections and Treatments
- Veterinary Orthopedics and Neurology
- Cervical and Thoracic Myelopathy
- Infectious Diseases and Tuberculosis
- Osteoarthritis Treatment and Mechanisms
- Medical Research and Treatments
- Reconstructive Surgery and Microvascular Techniques
- Head and Neck Surgical Oncology
- Nerve injury and regeneration
- Bone Metabolism and Diseases
- COVID-19 and Mental Health
- Orthopaedic implants and arthroplasty
- Child and Adolescent Psychosocial and Emotional Development
- Orthopedic Surgery and Rehabilitation
- Facial Nerve Paralysis Treatment and Research
- Sarcoma Diagnosis and Treatment
First Affiliated Hospital of Xinxiang Medical University
2025
First Affiliated Hospital of Bengbu Medical College
2012-2024
Bengbu Medical College
2003-2024
Wuhan Sixth Hospital
2020-2024
Jianghan University
2021
Shantou Central Hospital
2006-2009
Wuhan Wudong Hospital
2007
People 's Hospital of Jilin Province
2004
Abstract A key early sign of degenerative disc disease (DDD) is the loss nucleus pulposus (NP) cells (NPCs). Accordingly, NPC transplantation a treatment strategy for intervertebral (IVD) degeneration. However, in advanced DDD, due to structural damage IVD and scaffold mechanical properties, transplanted are less viable secrete extracellular matrix, thus, unable efficiently promote NP regeneration. In this study, we evaluated encapsulation NPCs photosensitive hydrogel made collagen...
Intervertebral disk degeneration is a common disease with an unknown etiology. Currently, tissue engineering considered to be important method for intervertebral repair. Although transplanted stem cells may disrupt the repair process because of apoptosis caused by oxidative microenvironment. Herein, bone marrow mesenchymal cell (BMSC) and Neochlorogenic acid (Ncg) were encapsulated into GelMA hydrogel as carrier protect cells. Ncg effectively inhibited stress reduced rate. A 5% had large...
Abstract Objective To explore the impact of virtual reality (VR) training on anti-fall ability and bone mineral density (BMD) among elderly patients admitted to a healthcare institution. Methods People (aged 50) with osteoporosis in an care institution Anhui Province June 2020 October 2021 were selected randomly divided into VR group ( n = 25) control 25). In group, rehabilitation system was used for training, while treated traditional fall prevention exercise intervention. The changes Berg...
Excessive apoptosis in intervertebral disc (IVD) cells is important IVD degeneration. Interleukin (IL)-1β has been shown to induce these cells. However, whether insulin-like growth factor-1 (IGF-1) inhibits IL-1β-induced the nucleus pulposus remains unclear. The purpose of this study was investigate effects IGF-1 on pulposus. Cells isolated from were grown culture a monolayer. These identified using immunohistochemistry for type II collagen and toluidine blue staining glycosaminoglycans....
Cell-based tissue engineering approaches have emerged as a realistic alternative for regenerative disc repair. The multidirectional differentiation potential of bone marrow mesenchymal stem cells (BMSCs) to treat degeneration intervertebral has also become viable option. We used 1% HAMA hydrogel carrier and co-encapsulated BMSCs Salvianolic acid B (SalB) into the reduce apoptosis transplanted cells. protective effect SalB on was first verified in vitro using CCK8 method, flow cytometry,...
Intervertebral disc (IVD) degeneration is a pathological process that affects the molecular, cellular, and tissue levels, but neither conservative nor surgical treatments currently address its root causes. Recent developments in genetic engineering technologies indicate biomedical treatment for IVD may be possible. Lentivirus has been utilized this study as gene vector to introduce insulin-like growth factor-1 (IGF-1) transforming factor-β3 (TGF-β3) into nucleus pulposus mesenchymal stem...
The excessive apoptosis of cells the nucleus pulposus may plays an important role in intervertebral disc (IVD) degeneration. It has been shown that pro-inflammatory cytokine tumour necrosis factor (TNF)-α can induce cell apoptosis. Insulin-like growth (IGF)-1 promote proliferation; however, whether or not IGF-1 inhibits TNF-α-induced yet elucidated. In this study, our objective was to create a potentially therapeutic viral vector, which could be used achieve enforced expression rabbit cells....
BACKGROUND The aim of this study was to investigate the effect curcumin treatment on expression N-methyl-D-aspartate receptor (NMDAR) subunit, NR2A, in a rat PC12 cell line treated with acetyl amyloid-β peptide, Aβ(25-35), an vitro model Alzheimer's disease. MATERIAL AND METHODS cells, derived from phaeochromocytoma, were for 24 hours increasing concentrations (5, 10, 20, 30 µM/L) presence Aβ(25-35). A Cell Counting Kit-8 (CCK-8) assay used determine viability, and flow cytometry measure...
Abstract Background Lumbar spondylolysis is a bone defect in the pars interarticularis of lumbar vertebral, which common cause low back pain youth. Although non-surgical treatment mainstream option, surgery necessary for patients with persistent symptoms. Buck technique widely used as classical direct repair technique, but it cannot achieve reduction low-grade spondylolisthesis and reconstruction lumbosacral sagittal balance. We have described novel surgical procedure based on temporary...
Background Adverse childhood experiences (ACEs) affect children’s development, and their harm to health is pervasive throughout the life course.Aims To identify ACEs risk factors in Chinese household with or without parental mental illness.Methods A controlled study was conducted among 181 young adults illness (positive group) 201 demographically matched individuals (negative group). Univariate multivariate analyses were performed correlation between factors.Results The positive group...
Endoscopic removal of nucleus pulposus (NP) intervertebral disc (IVD) on lumbar protrusion (LIDP) and its influence inflammatory factors immune function were explored. A total 145 patients with LIDP admitted to The First Affiliated Hospital Bengbu Medical College from June 2017 December 2018 selected electively treated, in which 87 treated fenestration discectomy (fenestration group) 58 endoscopic NP IVD (minimally invasive group). Effects the two groups within 6 months after surgery...
Hepatic fibrosis is the pathological repair response of liver to chronic injury; hepatic stellate cell (HSC) activation central link in pathogenesis fibrosis. Previously, we showed that kinetin, a plant cytokinin hormone, has protective effect on CCl4-induced injury mice. However, role kinetin remains unclear. We aimed study these effects and determine mechanisms by which mediates HSC apoptosis. For this purpose, human line LX-2 was treated with 10 ng/ml transforming growth factor-β1...
Intervertebral disc degeneration (IDD) is a natural progression of age-related processes. Associated with IDD, degenerative disease (DDD) pathologic condition implicated as major cause chronic lower back pain, which can have severe impact on the quality life patients. As associated elevated levels inflammatory cytokines, enhanced aggrecan and collagen degradation, changes in cell phenotype. The purpose this study was to investigate biological cytological characteristics rabbit nucleus...
Objective: This study was designed to compare the biomechanical properties of lumbar spondylolysis repairs using different fixation methods by three-dimensional finite element analysis. Methods: Five models (A, B, C, D, and E) L4-S1 vertebral body were reconstructed CT images a male patient (A: intact model; B: C: model with intrasegmental direct Buck screw; D: intersegmental indirect pedicle screw system; E: hybrid internal fixation). L5-S1 level defined as operative level. After verified,...