A5001084759- Effects and risks of endocrine disrupting chemicals
- Toxic Organic Pollutants Impact
- Gut microbiota and health
- MicroRNA in disease regulation
- Microplastics and Plastic Pollution
- Air Quality and Health Impacts
- Metabolomics and Mass Spectrometry Studies
- Clostridium difficile and Clostridium perfringens research
- Peroxisome Proliferator-Activated Receptors
- Microbial Community Ecology and Physiology
- Pluripotent Stem Cells Research
- Per- and polyfluoroalkyl substances research
- Pharmaceutical and Antibiotic Environmental Impacts
- Diet and metabolism studies
- Cancer Cells and Metastasis
- Fluoride Effects and Removal
- Adipose Tissue and Metabolism
- Antimicrobial Peptides and Activities
- RNA Research and Splicing
- Energy and Environment Impacts
- Molecular Biology Techniques and Applications
- Cancer-related molecular mechanisms research
- Tryptophan and brain disorders
- Silymarin and Mushroom Poisoning
- Nonlinear Optical Materials Research
Quanzhou Normal University
2020-2025
Jining Medical University
2024
Chinese Academy of Sciences
2004-2021
Institute of Electronics
2021
Institute of Urban Environment
2015-2020
University of Chinese Academy of Sciences
2009-2019
South China Botanical Garden
2009
Fujian Institute of Research on the Structure of Matter
2004
State Key Laboratory of Structural Chemistry
2004
Lipid accumulation in macrophages interacts with microenvironment signals and accelerates diabetic atherosclerosis. However, the molecular mechanisms by which macrophage metabolism during lipid are not clearly understood. Accordingly, an untargeted metabolomics approach was employed to characterize metabolic reprogramming, identify potential regulatory targets related treated oleate, important nutrient. The revealed that multiple pathways were significantly disturbed oleate-treated...
Fine particulate matter (PM2.5) exposure, especially to its organic components, induces adverse health effects on the respiratory system. However, molecular mechanisms have still not been fully elucidated. Long non-coding RNA (lncRNA) is involved in various physio-pathological processes. In this study, roles of lncRNA were investigated reveal toxicology PM2.5. Organic extracts PM2.5 from Nanjing and Shanghai cities adopted treat human bronchial epithelial cell lines (BEAS-2B A549)....
Intestinal microorganisms play a crucial role in chicken health and production performance, especially the research of traditional organic feeding methods. The intestinal contents feed chickens were analyzed by 16S rRNA gene metagenome technology. results showed that microbial diversity was significantly higher than chickens, key microorganisms, such as Enterococcus , more abundant chickens. functional analysis revealed significant difference metabolic function between them. present study...
The present study aims to investigate the effects of Perfluorolauric Acid (PFLA) on gut microbiota community and physiological health mice. experiment was conducted by setting a control group (CTRL) an experimental (PFLA), exposing mice PFLA observing changes in their indicators. results showed that exposure significantly altered β diversity mice, as evidenced NMDS, PCoA, PCA analyses, indicating clear change microbial structure between CTRL group. Moreover, led decrease α microbiota, with...
Perfluorooctane sulfonic acid (PFOS) is a persistent organic pollutant that has attracted much attention due to its wide environmental distribution and potential toxicity. Intestinal microbiota an important regulator of host health, composition metabolic function are easily interfered with by pollutants. In this study, the effects PFOS exposure on gut microbiota, lipid metabolism, health were investigated in mice. The results showed did not significantly change α diversity, but affected β...
Abstract Disordered intestinal metabolism is highly correlated with atherosclerotic diseases. Resveratrol protects against Accordingly, this study aims to discover novel proatherosclerotic metabolites and potential therapeutic targets related the anti‐atherosclerotic effects of resveratrol. An untargeted metabolomics approach was employed metabolic disturbances during atherosclerosis resveratrol intervention. We found that multiple pathways were significantly disturbed responsive Notably,...
Efficient removal of extremely mobile and toxic As(III) from water is a challenging but critical task. Herein, we developed functionalized sorbent chitosan nanofiber with iron–manganese (Fe-Mn@CS NF) using one-step hybrid electrospinning approach to remove trace water. Batch adsorption studies were performed determine the efficiency under variety conditions, including contact time, starting concentration As(III), ionic strength, presence competing anions. The experimental results...
Epidemiological studies have shown the possible link between phthalates and endometrium-related gynecological diseases, however molecular mechanism(s) behind this is/are still unclear. In study, both primary cultured endometrial cells an adenocarcinoma cell line (Ishikawa) were recruited to investigate effects of di-(2-ethylhexyl) phthalate (DEHP) at human-relevant concentrations. The results showed that DEHP did not affect viability either type cell, which different responses inflammation....
Abstract Tetrabromobisphenol A and tetrachlorobisphenol are halogenated bisphenol (H-BPA), has raised concerns about their adverse effects on the development of fetuses infants, however, molecular mechanisms unclear, related metabolomics studies limited. Accordingly, a study based gas chromatography-mass spectrometry was employed to elucidate developmental toxicology H-BPA using marine medaka (Oryzias melastigmas) embryo model. Here, we revealed decreased synthesis nucleosides, amino acids...
Abstract Heavy metal pollution has seriously disrupted eco-balance and transformed estuaries into sewage depots. Quanzhou bay is a typical heavy metal-contaminated estuary, in which Spartina alterniflora widely invaded. Plant-associated microbial communities are crucial for biogeochemical cycles, studies of would be helpful to demonstrate the invasion mechanisms plants. Meanwhile, they indispensable phytoremediation by enhancing tolerance plants, facilitating absorption rate promoting growth...