A5102013897- Genetics, Aging, and Longevity in Model Organisms
- Circadian rhythm and melatonin
- Muscle Physiology and Disorders
- Neuroscience and Neuropharmacology Research
- Cancer, Hypoxia, and Metabolism
- Axon Guidance and Neuronal Signaling
- Mesenchymal stem cell research
- Tissue Engineering and Regenerative Medicine
- Craniofacial Disorders and Treatments
- Nerve injury and regeneration
- Drug Transport and Resistance Mechanisms
- Natural Antidiabetic Agents Studies
- RNA modifications and cancer
- Photoreceptor and optogenetics research
- Cancer-related molecular mechanisms research
- Curcumin's Biomedical Applications
- Adipose Tissue and Metabolism
- Cleft Lip and Palate Research
- Neuroendocrine regulation and behavior
- 3D Printing in Biomedical Research
- Neuroscience of respiration and sleep
- GDF15 and Related Biomarkers
- Neuroinflammation and Neurodegeneration Mechanisms
Fudan University
2019-2025
Zhongshan Hospital
2019-2025
First Affiliated Hospital of Hunan University of Traditional Chinese Medicine
2025
Xiangtan University
2025
State Key Laboratory of Medical Neurobiology
2019-2024
Anhui Medical University
2023
Hunan University
2023
Henan University
2022
Bengbu Medical College
2020
ABSTRACT Astrocytes are the most abundant type of macroglia in brain and play crucial roles regulating neural development functions. The diverse functions astrocytes largely determined by their morphology, which is regulated genetic environmental factors. However, whether how astrocyte morphology affected temperature remains unknown. Here we discovered that elevated cultivation (26°C) stimulates Caenorhabditis elegans ventral CEPsh glia endfoot extension during early developmental stages....
Cough variant asthma (CVA) is a disease with no definitive diagnosis or pathogenic causes, and still lacks effective safe treatment. Wuhu decoction traditional Chinese medicine potential effects against CVA, of which underlying mechanism remains elusive. The aim this study to explore the therapeutic CVA. CVA mice model was established by ovalbumin (OVA) airway hyperresponsiveness remodeling were assessed. pulmonary inflammatory injury determined counting cells serum OVA-specific...
Abstract Transition metal‐based catalysts have been demonstrated to effectively anchor and utilize lithium polysulfides (LiPSs), thereby enhancing the capacity of lithium‐sulfur batteries (LSBs). However, immobilized d ‐band electronic structure a single transition metal is inadequate for achieving satisfactory adsorption catalytic conversion. In this study, an alloying strategy employed modulate with aim optimal LiPSs. For purpose, cobalt (Co)‐nickel (Ni) encapsulated in nitrogen‐doped...
Synaptic positions underlie precise circuit connectivity. can be established during embryogenesis and sustained growth. The mechanisms that sustain synaptic specificity allometric growth are largely unknown. We performed forward genetic screens in C. elegans for regulators of this process identified mig-17, a conserved ADAMTS metalloprotease. Proteomic mass spectrometry, cell biological studies demonstrate MIG-17 is secreted from cells like muscles to regulate basement membrane proteins. In...
Environmental factors such as temperature affect neuronal activity and development. However, it remains unknown whether how they synaptic subcellular specificity. Here, using the nematode Caenorhabditis elegans AIY interneurons a model, we found that high cultivation robustly induces defects in specificity through glutamatergic neurotransmission. Furthermore, determined functional glutamate is mainly released by ASH sensory neurons sensed two conserved inhibitory glutamate-gated chloride...
Extensive phase II metabolic reactions (i.e., glucuronidation and sulfation) have resulted in low bioavailability decreased biological effects of curcumin quercetin. Compared to glucuronidation, information on the sulfation disposition quercetin is limited. In this study, we identified that BCRP MRP4 played a critical role cellular excretion curcumin-O-sulfate (C-O-S) quercetin-O-sulfate (Q-O-S) by integrating chemical inhibition with transporter knock-down experiments. Inhibited sulfate...
ABSTRACT Synapses are largely established during embryogenesis and maintained growth. The mechanisms that regulate synaptic allometry—the maintenance of positions growth—are unknown. We performed forward genetic screens in C. elegans for allometry mutants identified mig-17 , a secreted metalloprotease the conserved ADAMTS family. Through proteomic mass spectrometry analyses, cell biological studies we determined MIG-17 is expressed by muscle cells to modulate glia location morphology. Glia...
Chemical synapses are essential for neuronal information storage and relay. The synaptic signal received or sent from spatially distinct subcellular compartments often generates different outcomes due to the distance physical property difference. Therefore, final output of postsynaptic neurons is determined not only by type intensity inputs but also location. How specificity has long been focus study in neurodevelopment field. Genetic studies invertebrates such as Caenorhabditis elegans (C....
Objective To detect the effect and safety of massage therapy on infants with congenital muscular torticollis. Methods A total 56 unilateral torticollis were enrolled in this retrospective comparative study. The subjects divided two groups, namely, control group group. ( n = 28) received treatment sternocleidomastoid muscle (SCM) stretching, while combined SCM stretching. following parameters compared: cervical range motion (ROM) functional level (muscle function scale ratio scores)....