A5031863819- Pancreatic function and diabetes
- Diet and metabolism studies
- Ophthalmology and Eye Disorders
- Renal function and acid-base balance
- Ion Transport and Channel Regulation
- CRISPR and Genetic Engineering
- Gut microbiota and health
- Mitochondrial Function and Pathology
- Wood and Agarwood Research
- Pluripotent Stem Cells Research
- Erythrocyte Function and Pathophysiology
- Microscopic Colitis
- Cultural Heritage Materials Analysis
- Glutathione Transferases and Polymorphisms
- Endoplasmic Reticulum Stress and Disease
- Ion channel regulation and function
- Pancreatitis Pathology and Treatment
- Biological Research and Disease Studies
- Genomics, phytochemicals, and oxidative stress
- Inflammasome and immune disorders
- X-ray Diffraction in Crystallography
- Single-cell and spatial transcriptomics
- Cell death mechanisms and regulation
- Electrolyte and hormonal disorders
- Nasolacrimal Duct Obstruction Treatments
Beijing Tongren Hospital
2019-2024
Capital Medical University
2019-2024
Palace Museum
2024
Fudan University
2024
Capital University
2021
Tongren Hospital
2021
Second Hospital of Shanxi Medical University
2021
Shanxi Medical University
2021
The spike (S) protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an important target for vaccine and drug development. However, the rapid emergence variant strains with mutated S proteins has rendered many treatments ineffective. Cleavage by host proteases essential viral infection. Here, we discovered that contains two previously unidentified Cathepsin L (CTSL) cleavage sites (CS-1 CS-2). Both are highly conserved among all known SARS-CoV-2 variants. Our structural...
Graves' ophthalmopathy (GO), the most frequent extrathyroidal manifestation of disease (GD), can lead to a significant decline in quality life patients. Exosomes, which contain proteins, lipids and DNA, play important roles pathological processes various diseases. However, their are still unclear. We aimed isolate exosomes analyze different exosomal proteins. Tear fluids were collected from twenty-four GO patients, GD patients sixteen control subjects. The numbers tear assayed using...
Graves' orbitopathy (GO) is an autoimmune disease with mechanical impairment of orbital muscles and lacrimal gland dysfunction. The frequently used methods assessing GO activity include Clinical Activity Score (CAS), CT, MRI. These approaches are mainly associated muscles; however, there not many studies that focus on the inflammation patients.The aim this study to assess usefulness 99mTc-DTPA single-photon emission (SPE) CT/CT in evaluating GO, as compared other methods.A retrospective...
Diabetes mellitus is caused by either insulin resistance or deficiency. The pancreatic β cells are the primary producers of insulin. Large-scale CRISPR screens combined with single-cell RNA sequencing (scRNA-seq) on has identified novel regulators and revealed presence a highly complex inner network. Here, we performed pooled delivery transcriptome analysis MIN6 cell line, β-cell line. We have presented scRNA-seq readout demonstrated that line might develop genetic heterogeneity increasing...
Mutations in KCNH6 has been proved to cause hypoinsulinemia and diabetes human mice. Cisapride is a stomach-intestinal motility drug used treat gastrointestinal dysfunction. reported be potential inhibitor of the KCNH family, but it remained unclear whether cisapride inhibited KCNH6. Here, we discovered role on glucose metabolism, focusing potassium channel protein. reduced blood level increased serum insulin secretion wild-type (WT) mice fed standard normal chow/a high-fat diet or db/db...
Genome-scale CRISPR–Cas9 knockout coupled with single-cell RNA sequencing (scRNA-seq) has been used to identify function-related genes. However, this method may knock out too many genes, leading low efficiency in finding genes of interest. Insulin secretion is controlled by several electrophysiological events, including fluxes KATP depolarization and K+ repolarization. It well known that glucose stimulates insulin from pancreatic β-cells, mainly via the channel, but whether other nutrients...
Abstract Appropriate Ca 2+ concentration in the endoplasmic reticulum (ER), modulating cytosolic signal, serves significant roles physiological function of pancreatic β cells. To maintaining ER homeostasis, movement across membrane is always accompanied by a simultaneous K + flux opposite direction. KCNH6 was proven to modulate insulin secretion controlling plasma action potential duration and intracellular influx. Meanwhile, specific β‐cells remains unclear. In this study, we found that...
Abstract Hard yellow paper is one of the few surviving Chinese famous from more than a thousand years ago. In particular, documents found in Dunhuang are important collections major museums around world. Although there has been some research before, production process still lot controversy. order to find out development materials and making craft, such as fiber, dyeing coating, 24 relics Tang Dynasty Gansu Provincial Museum have observed tested comprehensively by spectroscopy spectrometry...
Adult patients with a dysfunctional Protein interacting C-kinase 1 (PICK1) present hyperinsulinemia and hyperglycemia. PICK1 was reported to be peripheral membrane protein that controled insulin granule formation, trafficking, maturation in INS-1E cells. However, the mechanism of Pick1 glucose metabolism disorders has not been clearly defined. Here, we demonstrate β-cell-specific knockout (βKO) had impaired tolerance decreased serection. By contrast, overexpression primary pancreatic β-cells...
KCNH6 has been proven to affect glucose metabolism and insulin secretion both in humans mice. Further study revealed that Kcnh6 knockout (KO) mice showed impaired tolerance. However, the precise function of liver remains unknown. Mitochondria have suggested maintain intracellular Ca2+ homeostasis; ROS generation defective mitochondria can cause disorders, including type 2 diabetes (T2D). Here, we found attenuated disorders by decreasing PEPCK G6pase abundance induced Glut2 IRS2 expression....
Impaired fasting glucose (IFG) is a reversible intermediate hyperglycemia stage with an increasing risk of diabetes and related complications. Our study was designed to identify the relationship between serum anion gap progressing impaired diabetes. Here, we performed prospective, population-based among 1191 Chinese individuals aged 22–87 years who took health examinations annually 2006 2012 including clinical features plasma metabolites. All participants had no history or chronic Logistic...
Background: Gastrointestinal microbiota, particularly gut microbiota is an indispensable environmental factor in the progression of Rheumatoid Arthritis (RA). Understanding diversity and function intestinal flora patients with RA part parcel to understand relationship between human health. Objectives: This study aimed identify RA. Methods: A total 166 participants were recruited this study, comprising 93 73 age sex-matched healthy controls (HCs). Microbial genome was extracted from...
Abstract Backgound Impaired fasting glucose (IFG) is an invertible interim hyperglycemia period with increasing risk of diabetes and related complications. Our study was designed to identify that the serum anion gap progressing IFG diabetes. Methods We performed a prospective, population-based among 1191 Chinese individuals aged 22-87 years who taken health examinations annually between 2006 2012 including clinical features plasma metabolites. All participants had no history or chronic...
KCN, a human ether-a-go-go-related gene, encodes KCN ion channel in the Kv11 family, which ranks 11th abundance among different families. KCNH6, subfamily of potassium has been proven to affect glucose metabolism and insulin secretion both humans mice. However, precise function KCNH6 liver remains unknown. In this study, we showed that knockout (KO) Kcnh6 impairs mitochondrial tolerance as well promotes high-fat-diet-induced resistance. line, overexpression hepatocytes ameliorates fatty acid...
Abstract Impaired fasting glucose (IFG) is a reversible interim hyperglycemic period in which there an increasing risk of developing diabetes and related complications. Our study aimed to identify that serum anion gap the IFG development. We performed prospective, population-based among 1191 Chinese individuals aged 22–87 years who underwent health examinations annually between 2006 2012 including determining clinical biochemistry plasma metabolite parameters. All participants had no history...