A5075477392- Pancreatic function and diabetes
- Tuberculosis Research and Epidemiology
- Monoclonal and Polyclonal Antibodies Research
- Chemokine receptors and signaling
- Metabolism, Diabetes, and Cancer
- Mycobacterium research and diagnosis
- Pneumonia and Respiratory Infections
- Endoplasmic Reticulum Stress and Disease
- Gallbladder and Bile Duct Disorders
- Diabetes and associated disorders
- Glycosylation and Glycoproteins Research
- Biochemical effects in animals
- Diagnosis and treatment of tuberculosis
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Metabolism and Genetic Disorders
- Immune responses and vaccinations
- Cancer Mechanisms and Therapy
- Enzyme Production and Characterization
- Liver Disease Diagnosis and Treatment
- MicroRNA in disease regulation
- Microbial Metabolism and Applications
- Thyroid Cancer Diagnosis and Treatment
- Reproductive Health and Contraception
- Immunotherapy and Immune Responses
- ATP Synthase and ATPases Research
Beijing Tongren Hospital
2016-2022
Capital Medical University
2016-2022
Chinese Academy of Medical Sciences & Peking Union Medical College
2021
Nanjing Medical University
2021
Jiangsu Province Hospital
2021
Beijing Chao-Yang Hospital
2021
University of Pittsburgh Medical Center
2020
Air Force Medical University
2015
Xijing Hospital
2015
Seoul National University
2013
To determine the diagnostic accuracy of Xpert® MTB/RIF assay using samples obtained through bronchoscopy in patients with suspected pulmonary tuberculosis (PTB).We retrospectively reviewed records PTB for whom Xpert was performed on specimens. The sensitivity, specificity, positive predictive value (PPV) and negative (NPV) diagnosis active were calculated acid-fast bacilli (AFB) smear microscopy culture Mycobacterium from sputum or specimens as a reference standard.A total 132 included final...
Background: Intrahepatic cholangiocarcinoma (iCCA) is a highly malignant subtype of (CCA) with poor prognosis. In iCCA, the interplay between stroma and tumor cells results in resistance to adjuvant chemotherapy. Increasing evidence indicates that miR-206 participates progression, but its role iCCA still unclear. The aim this study was identify dysregulated expression further explore underlying mechanism. Methods: MiR-206 proven be downregulated tissues by qPCR, correlation clinical...
The aim of our study is to establish the reference intervals (RIs) thyroid hormones in a previously iodine-deficient area but presently more than iodine-adequate Western China, and also investigate factors which affect function. cross-sectional conducted Xi'an, was based on 2007-2008 China National Diabetes Metabolic Disorders Survey. Among 1286 participating adults, 717 were finally included as population. Thyrotropin (TSH), total triiodothyronine (T3), free (FT3), thyroxine (T4), (FT4),...
Adult patients with dysfunction in human ether-a-go-go 2 (hERG2) protein, encoded by KCNH6, present hypoinsulinemia and hyperglycemia. However, the mechanism of KCNH6 action glucose disorders has not been clearly defined. Previous studies identified that sustained endoplasmic reticulum (ER) stress-mediated apoptosis pancreatic β-cells directly contributed to diabetes. In study, we showed Kcnh6 knockout (KO) mice had impaired tolerance mediated high ER stress levels, increased elevated...
RFX6 transcription factor is believed to play a central role in directing cell development of insulin-producing pancreatic islet. homozygous mutations cause syndromic neonatal diabetes with hypoplastic pancreas. However, heterozygous maturity-onset the young (MODY) normal pancreas development. Here, we show that may control islet and insulin production different manners. The rfx6 knockout zebrafish generated by CRISPR/Cas9 exhibited an overt phenotype. Pancreatic failed form compact...
Serum alanine aminotransferase (ALT) is a biomarker of hepatocyte damage. However, the relationship between normal range serum ALT level and metabolic syndrome (MetS) has not been completely understood. This study aimed to investigate correlation MetS.A total 2453 participants from Beijing Community Pre-Diabetes were enrolled. Multiple linear regression analysis was performed calculate coefficient. Normal levels divided into quartiles. Logistic model used compare relative risk MetS, receiver...
KCNH6 has been proven to affect glucose metabolism and insulin secretion both in humans mice. Further study revealed that Kcnh6 knockout (KO) mice showed impaired tolerance. However, the precise function of liver remains unknown. Mitochondria have suggested maintain intracellular Ca2+ homeostasis; ROS generation defective mitochondria can cause disorders, including type 2 diabetes (T2D). Here, we found attenuated disorders by decreasing PEPCK G6pase abundance induced Glut2 IRS2 expression....
Abstract Adult patients with a dysfunctional ether-a-go-go 2 (hERG2) protein, which is encoded by the KCNH6 gene, present hyperinsulinemia and hyperglycemia. However, mechanism of in glucose metabolism disorders has not been clearly defined. It proposed that sustained endoplasmic reticulum (ER) stress closely concerned hepatic insulin resistance inflammation. Here, we demonstrate Kcnh6 knockout (KO) mice had impaired tolerance increased levels apoptosis, addition to displaying an was...
Objective To analyze the predictive parameters for therapeutic efficacy of metformin monotherapy in Chinese newly diagnosed patients with type 2 diabetes. Methods Subjects who were treated 48 weeks from Study on Mechanism acarbose Newly Type Diabetic Patient (MARCH study) November 2008 to June 2011 enrolled. To assess efficacy, a multiple linear regression analysis was performed, taking glycosylated hemoglobin (HbA1c) reduction as dependent variable, and baseline independent...
Objective To investigate the characteristics of components metabolic syndrome in young men with hypogonadotropic hypogonadism (HH). Methods A total 35 treatment–naive male patients (19.3±5.0) yrs) HH were included group, and 22 healthy similar age body mass index (BMI) recruited control group from June 2013 to September 2014. Serum sex hormones, follicle – stimulating hormone (FSH), luteinizing (LH) serum lipids levels measured fasting blood samples. Plasma glucose insulin taken...