A5081193491- Intracranial Aneurysms: Treatment and Complications
- Cerebrovascular and Carotid Artery Diseases
- Moyamoya disease diagnosis and treatment
- Gut microbiota and health
- Platelet Disorders and Treatments
- Diet and metabolism studies
- Hematological disorders and diagnostics
- Liver Disease Diagnosis and Treatment
- Hemostasis and retained surgical items
- Traumatic Brain Injury and Neurovascular Disturbances
- Acute Myeloid Leukemia Research
- Hemophilia Treatment and Research
- Diet, Metabolism, and Disease
- Cardiovascular Health and Disease Prevention
- Meningioma and schwannoma management
- Pancreatic function and diabetes
- CRISPR and Genetic Engineering
- Pluripotent Stem Cells Research
- Bone Metabolism and Diseases
- Microscopic Colitis
- Circular RNAs in diseases
- MicroRNA in disease regulation
- Biomarkers in Disease Mechanisms
- Dialysis and Renal Disease Management
- Microbial Community Ecology and Physiology
Daewoong Pharmaceutical (South Korea)
2025
Wuhan Union Hospital
2024
Huazhong University of Science and Technology
2020-2024
Southeast University
2024
Union Hospital
2020-2024
North China University of Science and Technology
2023
Hubei Provincial Center for Disease Control and Prevention
2023
Hebei Medical University
2014-2021
Aerospace Center Hospital
2013-2020
Peking University
2013-2019
Objective Patients with renal failure suffer from symptoms caused by uraemic toxins, possibly of gut microbial origin, as deduced studies in animals. The aim the study is to characterise relationships between intestinal microbiome composition, toxins and human end-stage disease (ESRD). Design Characterisation microbiome, serum faecal metabolome phenotypes a cohort 223 patients ESRD 69 healthy controls. Multidimensional data integration reveal links these datasets use chronic kidney (CKD)...
Patients receiving maintenance hemodialysis (MHD) are at increased risk of osteoporosis. The effects bilirubin on bone metabolism vary among different disease populations. However, the relationship between total (TBIL) and in MHD has not been investigated yet. This cross-sectional study included 122 patients aged ≥ 18 years who underwent regular Blood Purification Center Aerospace Central Hospital from April 2021 to 2023. sampling mineral density (BMD) examinations were conducted....
Introduction Declining physical or mental health in older dogs can lead to changes the dog's cognitive and musculoskeletal function. Regrettably, these degenerative cannot be remedied. In present study, geriatric small exhibiting behavioral were treated with human embryonic stem cell-derived mesenchymal stemcells (ES-MSCs, n = 21) extracellular vesicles (ES-MSC-EVs, 21). Methods Before 2 weeks after treatment, mobility status of assessed using theCanine Cognitive Dysfunction Rating (CCDR)...
Diabetic retinopathy (DR) remains as the most frequent complication of diabetes, and is major cause vision loss for middle-aged to elderly people. With longer life expectancies people with there a significant rise in diabetic worldwide. The treatment DR limited; therefore, our study aimed investigate possibilities circulating exosomal miRNAs early screening prevention DR; explore function DR.Eighteen participants were recruited divided into two groups: diabetes mellitus (DM) group group. We...
To investigate the role of hemodynamic stresses in initiating cerebral aneurysms at bends internal carotid artery (ICA). Sixty-one patients with 68 ICA were retrospectively enrolled as experiment group. Among 61 patients, 30 normal ICAs without chosen control. All had 3-dimensional angiography and CFD analysis. The bending angle was significantly ( P < .0001) smaller than control group (131.2º ± 14.9º vs 150.3º 9.5º). dynamic pressure, shear stress, vorticity magnitude strain rate least...
Abstract: The gut-islets axis is an important endocrine signaling that regulates the function of islets by modulating gut micro-environment and its metabolism. discovery intestinal hormones, such as GLP-1 GIP, has established a preliminary link between islet, paving way for development receptor agonists based on regulation theory diabetes treatment. This created new paradigm management rapidly made focal point research attention. Recent years, with in-depth study microbiota...
Objective: Tiny cerebral aneurysms are difficult to embolize because the aneurysm's sac is too small for a single coil, and coils within aneurysm may escape from confinement of stent.This study was performed introduce stent-assisted coil-jailing technique investigate its effect on coil embolization tiny intracranial aneurysms.Materials Methods: Sixteen patients with treated between January 2011 December 2013 were retrospectively reviewed followed-up.Results: All successfully technique, at...
Objective Intracranial aneurysms treated with endovascular coil embolization may recur. We investigated the factors affecting aneurysmal recurrence after and effects of retreatment within 1 year. Methods In 3 years, 1,335 patients 1,385 intracranial were embolization. Factors aneurysm analyzed. Results Angiography immediately following showed total occlusion in 1,030 (74.4%), neck remnant 207 (14.9%), partial 148 (10.7%), a peri-procedure complication rate 4.2%. Overall, 145 151 recurred...
Background: The "gut-islets axis" is an important endocrine signaling axis that regulates islets function by modulating the gut microbiota and metabolism within gut. However, specific mechanisms roles of intestine in regulation remain unclear. Recent studies investigated exosomes derived from can transport signals to remotely regulate β-cell function, suggesting possibility novel pathways mediated "gut-islet axis.". Methods: were isolated intestinal enteroendocrine cell-line STC-1cells...
Abstract Indole is a microbial metabolite produced by the gut microbiota through degradation of dietary tryptophan, known for its well‐established anti‐inflammatory and antioxidant properties. In this study, we collected fecal samples from mice fed high‐fat diet (HFD) those on standard (SD), then conducted 16S rRNA sequencing to analyze their microbiota. The analysis revealed distinct differences in dominant bacterial species between two groups, with significant decrease indole‐producing...
Hyperkalaemia occurs frequently in many maintenance haemodialysis (MHD) patients after parathyroidectomy (PTX) with secondary hyperparathyroidism (SHPT). However, the clinical risk factors that predict postoperative hyperkalaemia are uncertain. This retrospective cohort study included 90 aged ≥18 years who underwent PTX between April 2011 and 2016 at Aerospace Center Hospital (Peking University School of Clinical Medicine). Pre- post-PTX surgery venous samples were measured quadruplicate. We...
Hypertriglyceridemia is considered to be driven by increased lipolysis in type 1 diabetes mellitus (T1DM). However, information regarding the transcriptional circuitry that governs remains incomplete T1DM. Protein arginine methyltransferase 4 (PRMT4), a coactivation factor, promotes autophagy and may play an important role lipolysis. We wonder whether activated T1DM regulated PRMT4.Recombinant adeno-associated virus was adopted overexpress PRMT4 adipose tissue of mice. Streptozotocin (150...
Aneurysms with an acutely angled parent artery are difficult to access for coiling. This study aimed investigate the safety and effectiveness of microcatheter looping embolization cerebral aneurysms difficulty. Ten patients (male:female=5:5) treated technique were analyzed retrospectively. The formed acute angle major in five aneurysms. was looped into a “α” loop treatment anterior temporal aneurysm “U” remaining nine All ten successfully technique. tip navigated sac remained stable...