A5036917855- Gut microbiota and health
- Plant Pathogenic Bacteria Studies
- Diet and metabolism studies
- Plant Pathogens and Fungal Diseases
- Respiratory viral infections research
- Dermatology and Skin Diseases
- Pneumonia and Respiratory Infections
- SARS-CoV-2 and COVID-19 Research
- Clostridium difficile and Clostridium perfringens research
- Tryptophan and brain disorders
- Sugarcane Cultivation and Processing
- Spaceflight effects on biology
- Phytoplasmas and Hemiptera pathogens
- Oral microbiology and periodontitis research
- Space Exploration and Technology
- Dental Implant Techniques and Outcomes
- Planetary Science and Exploration
- SARS-CoV-2 detection and testing
- Pediatric health and respiratory diseases
- Genomics and Phylogenetic Studies
- Dental Health and Care Utilization
- Nanopore and Nanochannel Transport Studies
- Metabolism and Genetic Disorders
- Plant Virus Research Studies
- Cocoa and Sweet Potato Agronomy
Chinese Academy of Sciences
2011-2025
Hong Kong University of Science and Technology
2024-2025
University of Hong Kong
2023-2025
Yunnan Academy of Agricultural Sciences
2022-2024
Shenzhen Institutes of Advanced Technology
2022-2024
Sichuan University
2021-2024
West China Hospital of Sichuan University
2024
HKUST Shenzhen Research Institute
2023-2024
Shaanxi Institute of Zoology
2022-2024
City University of Hong Kong
2016-2023
Abstract The gut microbiota (GM) is related to obesity and other metabolic diseases. To detect GM markers for in patients with different abnormalities investigate their relationships clinical indicators, 1,914 Chinese adults were enrolled 16S rRNA gene sequencing this retrospective study. Based on composition, Random forest classifiers constructed screen the (Group OA) or without diseases O) from healthy individuals H), high accuracies observed discrimination of Group O OA (areas under...
To investigate whether patients with refractory epilepsy and healthy infants differ in gut microbiota (GM), how ketogenic diet (KD) alters GM.
The gut microbiota (GM) and its metabolites affect the host nervous system are involved in pathogeneses of various neurological diseases. However, specific GM alterations under pathogenetic pressure their contributions to "microbiota – metabolite brain axis" Alzheimer's disease (AD) remain unclear. Here, we investigated fecal, serum, cortical metabolomes APP/PS1 wild-type (WT) mice, revealing distinct hub bacteria AD mice within scale-free networks shared by both groups. Moreover, identified...
AIMTo determine whether oral administration of Bifidobacterium infantis CGMCC313-2 (B.infantis CGMCC313-2) inhibits allergen-induced airway inflammation and food allergies in a mouse model. METHODSOvalbumin (OVA)-induced allergic asthma b-lactoglobulin-induced allergy models were used this study.Following B. during or after allergen sensitization, histopathologic changes the lung intestine
Cerebral palsy (CP) and epilepsy are two interactive neurological diseases, their clinical treatment can cause severe side-effects in children's development, especially when it involves long-term administration of antiepileptic drugs. Accumulating studies on the gut-brain axis indicated that gut microbiota (GM), which participates various would provide a harmless therapeutic target for CP epilepsy. To explore GM characteristics children with both (CPE), we collected fecal samples from 25 CPE...
Colorectal cancer (CRC) causes high morbidity and mortality worldwide, noninvasive gut microbiome (GM) biomarkers are promising for early CRC diagnosis. However, the GM varies significantly based on ethnicity, diet living environment, suggesting varied biomarker performance in different regions. We performed a metagenomic association analysis stools from 52 patients 55 corresponding healthy family members who lived together to identify Chongqing, China. The of differed that controls. A total...
Idiopathic central precocious puberty (ICPP) is a common disease in preadolescence girls, and its pathogenesis remains to be uncovered. A variety of studies highlighted the association gut microbiota (GM) with endocrine diseases, such as obesity, which complication ICPP. However, relationship between GM ICPP unexplored. Feces samples were collected from 25 girls (ICPP group) 23 healthy (Control group). We applied 16S rDNA sequencing compare two groups. The group had higher diversity was...
The intimate association between the gut microbiota (GM) and central nervous system points to potential intervention strategies for neurological diseases. Nevertheless, there is currently no theoretical framework selecting window period target bacteria GM interventions owing complexity of microecosystem. In this study, we constructed a complex network-based modeling approach evaluate topological features infer bacterial candidates interventions. We used Alzheimer's disease (AD) as an example...
In the present study, we used two maternally inherited plastid DNA intergenic spacers, rpl20-rps12 and trnS-trnG, biparentally nuclear ribosomal internal transcribed spacer (ITS) region to explore genetic variation phylogeographical history of Rhodiola alsia, a herb endemic Qinghai-Tibetan Plateau (QTP). Based on range-wide sampling (18 populations 227 individuals), detected 45 haplotypes 19 ITS sequence types. Only three were widespread; most restricted single sites or neighbouring...
To investigate the impact of fecal microbiota transplantation (FMT) treatment on allergic colitis (AC) and gut (GM).We selected a total 19 AC infants, who suffered from severe diarrhea/hematochezia, did not relieve completely after routine therapy or cannot adhere to therapy, were free organ congenital malformations other contraindications for FMT. Qualified donor-derived stools collected injected infants via rectal tube. Clinical outcomes follow-up observations noted. Stools ten before FMT,...
Periodontitis and peri-implantitis are common biofilm-mediated infectious diseases affecting teeth dental implants have been considered to be initiated with microbial dysbiosis. To further understand the essence of oral microbiome dysbiosis in terms bacterial interactions, community structure, stability, we analyzed 64 plaque samples from 34 participants or under different health conditions using metagenomic sequencing. After taxonomical annotation, computed inter-species correlations,...
Background Alzheimer's disease (AD) is a complex neurodegenerative disorder with intricate pathophysiological mechanisms. Transcriptome analysis has been used to investigate the pathogenesis of AD from perspectives mRNA expression, alternative splicing, and polyadenylation. However, these 3 transcriptomic regulatory layers have not comprehensively explored, limiting our understanding landscapes pathogenesis. Objective We aimed describe pathogenesis, detect contributions different total...
In recent years, the morbidity of Mycoplasma pneumoniae pneumonia (MPP) has dramatically increased in China. An increasing number studies indicate that an imbalance respiratory microbiota is associated with infection. We selected 28 hospitalized patients infected M. and 32 healthy children. Nasopharyngeal (NP) oropharyngeal (OP) swabs were collected from children, whereas NP, OP bronchoalveolar lavage (BAL) specimens patients. Microbiota analysis was performed on all microbial samples using...
Cholestasis is a major hepatic disease in infants, with increasing morbidity recent years. Accumulating evidence has revealed that the gut microbiota (GM) associated liver diseases, such as non-alcoholic steatohepatitis, cirrhosis, and hepatocellular carcinoma. However, GM alterations cholestatic infants correlation between functions remain uninvestigated. In this study, 43 (IC group) 37 healthy (H were enrolled to detect discrepancies using 16S rDNA analysis. The diversity bacterial...
Infantile eczema is an immunological disease that characterized by itchy and dry skin. Recent studies have suggested gut microbiota (GM) plays a role in the development progression of eczema. To further evaluate this potential link, we collected feces from 19 infants with 14 without analyzed molecular discrepancies between two groups using 16S rDNA analysis.Bacteroidaceae Deinococcaceae were significantly enriched infants, Bacteroidaceae was potentially involved autoimmune diseases promoting...
Community-acquired pneumonia (CAP) is a worldwide infectious disease caused by bacteria, viruses, or combination of these agents. Mycoplasma pneumoniae an atypical pathogen that causes high morbidity and mortality in children, adenovirus can lead to severe pneumonia. However, the etiology different types still unclear. In this study, we selected total 52 inpatients with M. (MPP) (n=21), (AVP) (n=16), tracheomalacia (n=15) serve as control. Bronchoalveolar lavage fluid (BALF) samples had been...
Abstract Background The imbalanced respiratory microbiota observed in pneumonia causes high morbidity and mortality childhood. Respiratory metagenomic analysis demands a comprehensive microbial gene catalogue, which will significantly advance our understanding of host–microorganism interactions. Results We collected 334 samples from 171 healthy children 76 with pneumonia. catalogue we established comprised 2.25 million non-redundant genes, covering 90.52% prevalent genes. major oropharyngeal...
Abstract Nearly half of the species in large genus Saxifraga belong to sect. Ciliatae, a largely Sino‐Himalayan taxon. We report here that evidence from chloroplast DNA sequences (psbA‐trnH, trnL‐F) and nuclear (ITS) indicates this section is monophyletic composed at least three main lineages, corresponding (1) clade made up S. subsect. Gemmiparae, Cinerascentes, Flagellares Hemisphaericae, which last subsections are nested first; (2) belonging Rosulares (including Serpyllifoliae); (3)...
Plasmids are extrachromosomal genetic molecules that replicate independent of chromosomes in bacteria, archaea, and eukaryotic organisms. They contain diverse functional elements capable horizontal gene transfer among hosts. While existing plasmid databases have archived sequences isolated from individual microorganisms or natural environments, there is a need for comprehensive, standardized, annotated database to address the vast accumulation sequences. Here, we propose PlasmidScope...
Pneumonia is one of the most serious diseases for children, with which lung microbiota are proved to be associated. We performed 16S rDNA analysis on broncho-alveolar lavage fluid (BALF) 32 children tracheomalacia (C group), pneumonia infected Streptococcus pneumoniae (S. pneumoniae) (D1 group) or Mycoplasma (M. (D2 group). Children held lower microbial diversity and accumulated Lactococcus (mean ± SD, 45.21%±5.07%, P value <0.05), Porphyromonas (0.12%±0.31%, <0.05). D1 D2 group were...