A5077170267- interferon and immune responses
- Aquaculture disease management and microbiota
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Genomics and Phylogenetic Studies
- Identification and Quantification in Food
- Immune Response and Inflammation
- Circular RNAs in diseases
- Genetic diversity and population structure
- Invertebrate Immune Response Mechanisms
- Aquaculture Nutrition and Growth
- Ichthyology and Marine Biology
- Viral Infections and Vectors
- RNA modifications and cancer
- NF-κB Signaling Pathways
- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- Fish Biology and Ecology Studies
- Plant-Microbe Interactions and Immunity
- Animal Virus Infections Studies
- Complement system in diseases
- Toxoplasma gondii Research Studies
- Cytokine Signaling Pathways and Interactions
- RNA and protein synthesis mechanisms
- Chemokine receptors and signaling
Qingdao National Laboratory for Marine Science and Technology
2019-2025
Shanghai Ocean University
2009-2025
University of Maryland, Baltimore
2025
Shanghai Innovative Research Center of Traditional Chinese Medicine
2024
The University of Texas Southwestern Medical Center
2024
Yanshan University
2023-2024
Beijing Academy of Agricultural and Forestry Sciences
2015-2023
Suzhou Traditional Chinese Medicine Hospital
2020
Zhejiang Institute of Freshwater Fisheries
2020
Zhejiang Ocean University
2010-2019
Abstract Background Completing a genome is an important goal of assembly. However, many assemblies, including reference are unfinished and have number gaps. Long reads obtained from third-generation sequencing (TGS) platforms can help close these gaps improve assembly contiguity. current gap-closure approaches using long require extensive runtime high memory usage. Thus, fast memory-efficient approach needed to obtain complete genomes. Findings We developed LR_Gapcloser rapidly efficiently...
Abstract The miiuy croaker, Miichthys , is a representative Sciaenidae known for its exceptionally large otoliths. This species mainly inhabits turbid aquatic environments with mud to sandy bottoms. However, the characteristics of immune system this organism and specific environment adaptations are poorly understood. Thus, we present high-quality draft genome croaker. expansions several gene families which critical fish innate were identified. Compared genomes other fishes, some changes have...
Increasing evidence suggests important roles for long noncoding RNAs (lncRNAs) as new gene modulators involved in various biological processes. However, the function of lncRNAs lower vertebrates are still unknown. Here, we firstly identify a lncRNA, named MAVS antiviral-related lncRNA (MARL), key regulator antiviral immunity teleost fish. The results indicate that fish play essential host responses and inhibition Siniperca chuatsi rhabdovirus (SCRV) replication. miR-122 reduces expression...
Increasing evidence shows that the long noncoding RNA (lncRNA) is a major regulator and participates in regulation of various physiological pathological processes, such as cell proliferation, differentiation, metastasis, apoptosis. Unlike mammals, however, study lncRNA lower invertebrates just beginning extent lncRNA-mediate remains unclear. Here, we for first time identify an lncRNA, termed nucleotide oligomerization domain 1 (NOD1) antibacterial antiviral-related (NARL), key innate...
Abstract The inflammatory response, a protective process to clear detrimental stimuli, constitutes the defense against infectious pathogens. However, excessive inflammation disrupts immune homeostasis, which may induce autoimmune and diseases. In this study, we report that microRNA (miR)-3570 plays negative role in bacteria-induced response of miiuy croaker. Upregulation miR-3570 by Vibrio anguillarum LPS inhibits LPS-induced cytokine production, thus avoiding an response. Evidence showed...
ABSTRACT Effectively recognizing invading viruses and subsequently inducing innate antiviral immunity are essential for host defense. Although these processes closely regulated by the to maintain immune balance, have evolved ability downregulate or upregulate their survival. MicroRNAs (miRNAs) a family of small noncoding RNAs that play vital roles in modulating response. Accumulating evidence demonstrates miRNAs as mediators involved regulating viral replication mammals. However, underlying...
Lipopolysaccharide (LPS) is the major component of outer membrane Gram-negative bacteria. This molecule can induce strong immune response and various biological effects. In mammals, TLR4 recognize LPS inflammatory response. However, innate receptor in fish for recognizing remains ambiguous. invade cytoplasm via vesicles produced by bacteria could be detected intracellular caspase-11 so, there may also exist receptors that fish. NOD1 a member NOD-like family iE-DAP mammals. fish, respond to...
Background The miiuy croaker (Miichthys miiuy) is an important species of marine fish that supports capture fisheries and aquaculture. At present commercial scale aquaculture this limited due to diseases caused by pathogens parasites which restrict production limit value. lack transcriptomic genomic information for the limits ability researchers study pathogenesis immune system species. In we constructed a cDNA library from liver, spleen kidney was sequenced using Illumina paired-end...
Viral infection induces type I IFN production, which plays critical roles in orchestrating the antiviral defense by inducing direct activities. To establish a persistent infection, viruses have evolved numerous strategies to specifically interfere with production or its downstream mediators, thereby evading immune responses. MicroRNAs (miRNAs) are family of small noncoding RNAs that posttranscriptionally regulate expressions specific target genes. Although accumulating evidence demonstrates...
Upon recognition of bacterial pathogens by pattern receptors, cells are activated to produce pro-inflammatory cytokines and type I IFN multiple signaling pathways. Every step the process must be precisely regulated prevent dysregulation. MicroRNAs (miRNAs) have been shown important regulators with profound effects on inflammatory response. Nevertheless, miRNA-mediated regulatory mechanism remains unclear in fish species. Here, we addressed role miiuy croaker miR-214 bacteria triggered could...
Inflammation is the host self-protection mechanism to eliminate pathogen invasion. The excessive inflammatory response can result in uncontrolled inflammation, autoimmune diseases, or dissemination. Recent studies have widely shown that microRNAs (miRNAs) contribute regulation of inflammation mammals by repressing gene expression at posttranscriptional level. However, miRNA-mediated fish remains hazy. In present study, regulatory miR-216a-mediated teleost was addressed. We found miR-216a...
Eradication of bacterial infection requires timely and appropriate immune inflammatory responses, but excessive induction cytokines can cause acute or chronic disorders. Thus, various layers negative regulators mechanisms are needed to ensure maintenance the homeostasis for system. miRNAs a family small noncoding RNAs that emerged as significant versatile involved in regulation responses. Recently, molecular miRNA host-pathogen interaction networks have been extensively studied mammals,...
Circular RNAs (circRNAs) represent a class of widespread and diverse covalently closed circular endogenous that exert crucial functions in regulating gene expression mammals. However, the function regulation mechanism circRNAs lower vertebrates are still unknown. Here, we discovered novel circRNA derived from Deltex E3 ubiquitin ligase 1 (Dtx1) gene, namely, circDtx1, which was related to antiviral responses teleost fish. Results indicated circDtx1 played essential roles host immunity...
Circular RNAs (circRNAs) are a class of widespread and diverse covalently closed circular endogenous that exert crucial functions in regulating gene expression mammals. However, the function regulation mechanism circRNAs lower vertebrates still unknown. Here, we discovered novel circRNA derived from PIKfyve, named circPIKfyve, is related to antiviral responses teleost fish. The results showed circPIKfyve plays essential roles host immunity inhibition SCRV replication. Moreover, also found...
Abstract Circular RNA (circRNA) is produced by splicing head to tail and widely distributed in multicellular organisms, circRNA reportedly can participate various cell biological processes. In this study, we discovered a novel exon–intron derived from probable E3 ubiquitin-protein ligase RNF217 (RNF217) gene, namely, circRNF217, which was related the antibacterial responses teleost fish. Results indicated that circRNF217 played essential roles host immunity inhibited Vibrio anguillarum...
Background The Chinese salamander (Hynobius chinensis), an endangered amphibian species of endemic to China, has attracted much attention because its value studying paleontology evolutionary history and decreasing population size. Despite increasing interest in the Hynobius chinensis genome, genomic resources for are still very limited. A comprehensive transcriptome chinensis, which will provide a resource genome annotation, candidate genes identification molecular marker development should...