A5086818507- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Gout, Hyperuricemia, Uric Acid
- Sinusitis and nasal conditions
- Pharmacological Effects of Natural Compounds
- Monoclonal and Polyclonal Antibodies Research
- Allergic Rhinitis and Sensitization
- Crystallography and molecular interactions
- Nasal Surgery and Airway Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Osteoarthritis Treatment and Mechanisms
- Phytochemistry and Biological Activities
- Orthopaedic implants and arthroplasty
- Natural product bioactivities and synthesis
- Radiopharmaceutical Chemistry and Applications
- Chromosomal and Genetic Variations
- Neurogenesis and neuroplasticity mechanisms
- Inflammasome and immune disorders
- Hip disorders and treatments
- Tryptophan and brain disorders
- Bone and Joint Diseases
- Asthma and respiratory diseases
- Bioenergy crop production and management
- Algal biology and biofuel production
- Quinazolinone synthesis and applications
Eye & ENT Hospital of Fudan University
2008-2025
Sun Yat-sen University
2023-2025
Xi'an Jiaotong University
2020-2024
Nanjing University of Chinese Medicine
2015-2024
Fudan University
2008-2024
Huazhong Agricultural University
2020-2022
Jiangsu Provincial Hospital of Traditional Chinese Medicine
2022
Air Force Medical University
2015-2021
Tang Du Hospital
2020
Weatherford College
2020
Hepatocellular carcinoma (HCC) is a highly vascular tumor with high microvessel density and levels of circulating endothelial growth factor (VEGF). Thus, the angiogenesis pathway an attractive therapeutic target for HCC. The anti-tumor effects evodiamine, quinolone alkaloid isolated from Euodia rutaecarpa (Juss.) Benth. (Rutaceae), were investigated in mouse xenograft model using BALB/c nude mice, various HCC cell lines (HepG2, SMMC-7721, H22), human umbilical vein cells (HUVECs). evodiamine...
Systemic lupus erythematosus (SLE) is a complex autoimmune disease of unknown etiology. It marked by the production pathogenic autoantibodies and deposition immune complexes. Lupus nephritis (LN) prevalent challenging clinical complications SLE. Cortex Moutan contains paeonol as its main effective component. In this study, using animal model SLE induced R848, it was found that could alleviate lupus-like symptoms mouse R848 activating TLR7, reduce mortality ameliorate renal damage mice. order...
purpose. To determine the role of microglial activation in light-induced photoreceptor degeneration and neuroprotective effects naloxone as a novel inhibitor. methods. Sprague–Dawley rats were exposed to intense blue light for 24 hours. Daily intraperitoneal injection or PBS control was given 2 days before exposure continued weeks. Apoptotic cells detected by TUNEL assay, anti-OX42 antibody used label retinal microglia. Western blot applied evaluate interleukin (IL)-1β protein levels....
Abstract Background To compare the safety and efficacy between endoscopic sinus surgery different biologics in treating chronic rhinosinusitis with nasal polyps adults by reviewing existing clinical trials. Methods Data extraction risk of bias assessment were conducted 2 independent reviewers according to PRISMA recommendations any disagreement was resolved a third investigator. Outcomes measured through random‐effects model. We searched Embase, Web Science, MEDLINE, Cochrane, other relevant...
Molecular hydrogen (H2) exhibits antioxidant, anti-inflammatory and anti-apoptotic effects, has shown benefits in glucose lipid metabolism certain animal metabolic disorder models. However, the potential of H2 treatment individuals with impaired fasting (IFG) seldom been studied. This randomized controlled study (RCT) aims to investigate effects hydrogen-rich water (HRW) on IFG subjects explore underlying mechanism involved.Seventy-three patients were enrolled a randomized, double-blind,...
Sleep deprivation (SD) triggers mitochondrial dysfunction and neural inflammation, leading to cognitive impairment mental issues. However, the mechanism involving inflammation still remains unclear. Here, we report that SD rats exhibited multiple behavioral disorders, brain oxidative stress, robust DNA (mtDNA) oxidation. In particular, activated microglia microglial mtDNA efflux cytosol provoked pro-inflammatory cytokines. We observed cytokines significantly reduced with suppression of With...
Methicillin-resistant Staphylococcus aureus (MRSA), also known as oxacillin-resistant S. aureus, is a leading cause of community and hospital associated infections globally. In this work, we found that deletion the arlRS two-component system genes in USA300 USA500 strains resulted increased susceptibilities to oxacillin (8-16-fold decrease minimal inhibitory concentrations). USA300ΔarlRS, transcriptional levels mecA or blaZ showed no obvious change, while mRNA spx 4-fold at 4 h 6.3-fold 10...
Alzheimer's disease (AD) is the most prevalent form of dementia in aging population; however, no effective therapy has been established. It previously demonstrated that daily intake hydroxytyrosol (HT), a polyphenol olive oil, at dietary level mildly improves cognition AD mice. In present study, HT acetate (HT-ac), which natural derivative oil exhibits better bioactivity than cognition.
Inherited retinal degenerations (IRDs) are important causes of progressive, irreversible blindness. Hereditary macular diseases in particular significant their effect on the specialized, central cone photoreceptor-rich macula responsible for high resolution vision. Autosomal dominant Best vitelliform dystrophy (BVMD), caused by variants BEST1 gene, is one most common inherited dystrophies. Gene therapies have emerged as promising treatments IRDs, but a lack suitable animal models has...
Chronic rhinosinusitis with nasal polyps (CRSwNP) is an inflammatory upper airway disease, divided into eosinophilic CRSwNP (eCRSwNP) and noneosinophilic (neCRSwNP) according to levels. Neutrophils are major effector cells in CRSwNP. but their role different environments remain largely unclear. We performed integrated transcriptome analysis of polyp-infiltrating neutrophils from patients, using healthy donor blood as a control. Flow cytometry vitro studies showed that activated both type....
Chronic rhinosinusitis with nasal polyps (CRSwNP) is a heterogeneous inflammatory disease varying patterns across regions. This study aims to investigate the clinical and histopathological features of CRSwNP in Xizang, high-altitude region China. We retrospectively analyzed patients from Shanghai Xizang who underwent functional endoscopic sinus surgery (FESS) between 2017 2024. Polyp tissue samples were assessed, statistical analyses compared two regions CRSwNP, eosinophilic (eCRSwNP),...
<ja:p>The most direct approach in breeding triploid is crossing allotetraploids with diploids. However, the lack of allotetraploid restricts application this approach. In investigation, zygotic chromosome doubling was induced colchicine and high temperatures to produce (( Ã âZheyin3#â) (. )) allotetraploids. We screened 6 25 tetraploid individual offspring from high-temperature treatments respectively, indicating that both temperature are effective for production by . Developmental...
Pharmacognosy Magazine ,2017,13,52,693-701.DOI:10.4103/pm.pm_560_16Published:November 2017Type:Original Article Authors:Yanmei Cao, Cuicui Gu, Fangli Zhao, Yuanlin Tang, Xiaobing Cui, Le Shi, Li Xu, and Lian Yin Author(s) affiliations:Yanmei Department of Chinese Materia Medica, College Pharmacy, Nanjing University Medicine, 210023 Nanjing, China Abstract:Background: Cyathula officinalis Kuan is widely used in the clinics for treatment blood stasis China. Objective: To evaluate improving...
Nonsteroidal anti-inflammatory drugs are the first-line option for treating ankylosing spondylitis (AS) in China. However, no large-scale controlled trials have been conducted this ethnic population.To evaluate efficacy and safety of 6 weeks' treatment with celecoxib patients AS China.This Phase 3, double-blind, parallel-group study randomized aged ≥18 to 65 years 1:1 receive 200 mg once daily or diclofenac sustained release 75 daily. After weeks, could use 400 maintain blinded therapy. The...