A5100364775- Neuroinflammation and Neurodegeneration Mechanisms
- Cardiovascular Function and Risk Factors
- Neurological Disease Mechanisms and Treatments
- Transcranial Magnetic Stimulation Studies
- Vestibular and auditory disorders
- Spinal Cord Injury Research
- Dementia and Cognitive Impairment Research
- Tryptophan and brain disorders
- Neural and Behavioral Psychology Studies
- Neuroscience and Neuropharmacology Research
- Cardiac Ischemia and Reperfusion
- Cardiomyopathy and Myosin Studies
- Traumatic Brain Injury and Neurovascular Disturbances
- Cannabis and Cannabinoid Research
- Retinal Development and Disorders
- Identity, Memory, and Therapy
- Brain Tumor Detection and Classification
- Helicobacter pylori-related gastroenterology studies
- Stress Responses and Cortisol
- Gait Recognition and Analysis
- Neonatal and fetal brain pathology
- Diabetic Foot Ulcer Assessment and Management
- Neurogenesis and neuroplasticity mechanisms
- Cardiac Fibrosis and Remodeling
- Cardiac electrophysiology and arrhythmias
Harbin Medical University
2024-2025
Second Affiliated Hospital of Harbin Medical University
2024-2025
Tongji Hospital
2024
Huazhong University of Science and Technology
2024
Wuhan Sixth Hospital
2023
Shanghai East Hospital
2023
New York Medical College
2022
First Affiliated Hospital of Chengdu Medical College
2022
National Clinical Research Center for Digestive Diseases
2022
People's Liberation Army No. 150 Hospital
2022
The cannabinoid receptor 2 (CB2R) has been considered as a potential therapeutic target to ameliorate the neuroinflammation and cognitive impairments of Alzheimer's disease (AD). However, there little research on diverse roles CB2R in regulating different forms abilities underlying neuroinflammatory mechanisms. Thus, focus present study was investigate effects activation abilities, phenotype conversion microglia, dendrite complexity. Results showed that normalized cortex-dependent novel...
Sleep deprivation (SD) triggers mitochondrial dysfunction and neural inflammation, leading to cognitive impairment mental issues. However, the mechanism involving inflammation still remains unclear. Here, we report that SD rats exhibited multiple behavioral disorders, brain oxidative stress, robust DNA (mtDNA) oxidation. In particular, activated microglia microglial mtDNA efflux cytosol provoked pro-inflammatory cytokines. We observed cytokines significantly reduced with suppression of With...
Previous studies have shown that patients with acoustic neuroma (AN) sometimes present sudden sensorineural hearing loss (SSNHL) as an initial symptom. The purpose of this research was to investigate the clinical characteristics, diagnosis, and treatment AN in initially diagnosed SSNHL.We reviewed retrospectively medical records all who were treated SSNHL later after undergoing magnetic resonance imaging (MRI) at our hospital between 2008 2021. Patient demographics, associated complaints...
Cerebral ischemia starts with cerebral blood flow interruption that causes severely limited oxygen and glucose supply, eliciting a cascade of pathological events, such as excitotoxicity, oxidative stress, calcium dysregulation, inflammatory response, which could ultimately result in neuronal death. Hirudin has beneficial effects ischemic stroke possesses antioxidant anti-inflammatory properties. Therefore, we investigated the biological functions hirudin its related mechanisms ischemia. The...
Astrocytic Ca2+ transients are essential for astrocyte integration into neural circuits. These primarily sequestered in subcellular domains, including primary branches, branchlets and leaflets, endfeet. In previous studies, it suggests that aging causes functional defects astrocytes. Until now, was unclear whether how affects astrocytic at domains. this study, we combined a genetically encoded sensor (GCaMP6f) vivo two-photon imaging to determine changes within domains during brain aging. We...
391 Background: Claudin18.2 (CLDN18.2) is normally confined in tight junction of the gastric mucosa, but also often expressed several cancer types. AB011 a humanized, anti-CLDN18.2 monoclonal antibody (IgG1), which has shown impressive therapeutic synergy between and cytotoxic agents preclinical research. Here we report preliminary data on both as monotherapy combined with CAPOX patients advanced solid tumors (AB011-ST-01, NCT04400383). Methods: The primary objectives were to evaluate safety...
Depression is a prevalent psychiatric disorder. Microglial state transition has been found in many neurological disorders including depression. Gypenosides (Gypenosides I-LXXVIII, Gps) are saponin extracts isolated from the traditional Chinese herb Gynostemma pentaphyllum (Thunb.) Makino that exert anti-inflammatory and neuroprotective activities regulate depression-like behaviors. However, its effect on microglial depression remains unknown. We aimed to evaluate potential relationship...
Transcranial direct current stimulation (tDCS) is a non-invasive method to modulate cortical excitability in humans. Here, we examined the effects of anodal tDCS on suprahyoid motor evoked potentials (MEP) when applied over hemisphere with stronger and weaker suprahyoid/submental projections, respectively, while study participants performed swallowing task. Thirty healthy volunteers were invited two experimental sessions randomly assigned one different groups. While first group was targeted...
Background: Executive function tends to decline as people age. Transcranial direct current stimulation (tDCS) is assumed have beneficial effects on various cognitive functions. Some prior investigations shown that repeated sessions of tDCS enhance the executive performance healthy elderly by mediating training gains. However, studies effect long-term without are absent. Objective: The purpose this study was explore whether older adults could be enhanced with alone applied prefrontal cortex....
Memory decline has become an issue of major importance in the aging society. Anodal transcranial direct current stimulation (atDCS) is a viable tool to counteract age-associated episodic memory deterioration. However, underlying neural mechanisms are unclear. In this single-blind, sham-controlled study, we combined atDCS and functional magnetic resonance imaging assess behavioral consequences multiple-session older adults. Forty-nine healthy adults received either 10 sessions anodal or sham...
Multiple sclerosis (MS) is a chronic inflammatory autoimmune disease characterized by demyelination and neurodegeneration, for which traditional treatment offers limited relief. Microglial/macrophage modulation plays critical role in the pathogenesis of MS. Oxygen free radical accumulation can induce axonal nerve cell damage, further promote MS development. We created new recombinant protein based on flagellin from Legionella pneumophila named A with linked C- N-terminal ends (FLaAN/C), an...
Background Cushing's syndrome (CS) is associated with increased risk for heart failure, which often initially manifests as left ventricular diastolic dysfunction (LVDD). In this study, we aimed to explore the potential factors of LVDD in CS by incorporating body composition parameters.
Abstract Gait phase prediction is important in controlling assistive robotic devices such as exoskeletons, where the control unit must differentiate between gait phases to provide necessary assistance when user wearing exoskeleton. To achieve objective of precisely identifying users for accurate exoskeleton, this study proposes Auto-Correlation and Channel Attention enhanced Deep Graph Convolutional Networks (ACCA-DGCN) prediction, a model based on multiple inertial measurement units (IMUs)...
Multimodal magnetic resonance imaging (MRI) can reveal different patterns of human tissue and is crucial for clinical diagnosis. However, limited by cost, noise manual labeling, obtaining diverse reliable multimodal MR images remains a challenge. For the same lesion, MRI manifestations have great differences in background information, coarse positioning fine structure. In order to obtain better generation segmentation performance, coordination-spatial attention adversarial network (CASP-GAN)...
Objective To investigate the effect of cocaine-amphetamine-regulated transcript peptide （CART） on content of4-hydroxy-2-noneral （HNE） and infarct volume after cerebral ischemiaJreperfusion in mice. Methods A total 96 healthy male mice were randomly divided into four groups： ischemla/reperfusion （n =27）, CART normal saline control =27） sham operation = 15） groups. middle artery occlusion （MCAO） model was induced. Two hours MCAO, 55-102 equivalent injected respectively via tail veins group...
Objective To compare 6 sub-function scale differences of frontal lobe function rating or a Frontal Assessment Battery(FAB)among patients with two subtypes vascular cognitive impairment(VCI)to provide clues for the distinctive intervention and disease prevention control subtypes. Methods Totally 220 non-dementia impairment(NDVCI)patients 68 dementia(VaD)with final diagnosis were selected.The overall six scores tested by FAB.Analyzing score difference probing progress tendency from...
Abstract Objective : Older adults with subjective memory complaints (SMC) have a higher risk of dementia and commonly demonstrate symptoms depression anxiety. The study aimed to examine the effect training program for individuals SMC, whether combined group counseling at alleviating anxiety would boost gains. Design A three-armed, double-blind, randomized controlled trial. Setting Participants Community-dwelling older aged ≥ 60 years. Methods (n = 124) were randomly assigned (MT), (GC), or...