A5025761177- Mesenchymal stem cell research
- Surgical Sutures and Adhesives
- Tissue Engineering and Regenerative Medicine
- Hormonal and reproductive studies
- Gastrointestinal Bleeding Diagnosis and Treatment
- Wound Healing and Treatments
- Soft Robotics and Applications
- Microfluidic and Bio-sensing Technologies
- Micro and Nano Robotics
- Surgical Simulation and Training
- Cancer, Hypoxia, and Metabolism
- Helicobacter pylori-related gastroenterology studies
- Pregnancy-related medical research
- Diet and metabolism studies
- Intestinal and Peritoneal Adhesions
- Gastric Cancer Management and Outcomes
- Endometriosis Research and Treatment
- Hemostasis and retained surgical items
- Advanced Drug Delivery Systems
- Uterine Myomas and Treatments
- Menopause: Health Impacts and Treatments
- Electrospun Nanofibers in Biomedical Applications
- Innovative Microfluidic and Catalytic Techniques Innovation
- Maternal Mental Health During Pregnancy and Postpartum
- Clinical Nutrition and Gastroenterology
Chinese PLA General Hospital
2025
Chinese University of Hong Kong
2015-2024
Sun Yat-sen University
2020-2024
Sun Yat-sen University Cancer Center
2020-2024
Fudan University
2013-2023
Wuhan Sixth Hospital
2023
National Health and Family Planning Commission
2023
Prince of Wales Hospital
2015-2020
Obstetrics and Gynecology Hospital of Fudan University
2009-2019
Affiliated Hospital of Shaanxi University of Chinese Medicine
2018
Abstract Achieving rapid and effective hemostasis on irregularly shaped, non‐compressible visceral, high‐pressure arterial bleeding wounds remains a critical clinical challenge. Herein, an ultrafast self‐gelling wet adhesive polyethyleneimine/polyacrylic acid/quaternized chitosan (PEI/PAA/QCS) powder is reported as the hemostatic material wound dressing. PEI/PAA/QCS deposited can rapidly absorb large amount of blood to concentrate coagulation factors. Meanwhile, form hydrogel in situ within...
High-precision delivery of microrobots at the whole-body scale is considerable importance for efforts toward targeted therapeutic intervention. However, vision-based control microrobots, to deep and narrow spaces inside body, remains a challenge. Here, we report soft resilient magnetic cell microrobot with high biocompatibility that can interface human body adapt complex surroundings while navigating body. We achieve time-efficient using an integrated platform called endoscopy-assisted...
Achieving strong adhesion of bioadhesives on wet tissues remains a challenge and an acute clinical demand because the interfering interfacial water limited adhesive-tissue interactions. Here we report self-gelling adhesive polyethyleneimine polyacrylic acid (PEI/PAA) powder, which can absorb to form physically cross-linked hydrogel in situ within 2 seconds due physical interactions between polymers. Furthermore, polymers diffuse into substrate polymeric network enhance adhesion. Superficial...
Bioadhesive hydrogel with ultrafast gelation independent of environmental pH is endoscopically delivered to enhance gastric ulcer healing.
A key challenge for the effective treatment of gastrointestinal diseases including inflammatory bowel disease is to develop an orally administered drug delivery system capable prolonged retention in tract. Herein we report a bioadhesive liquid coacervate based on hydrogen bonding-driven nanoparticle assembly. Free from electrostatic interactions, our fluid nanoparticle-assembled demonstrates significant pH- and salt-independent structural stability forms physically adhesive coating large...
This paper presents an enhanced control method for a doubly fed induction generator (DFIG)-based wind-power generation system with series grid-side converter (SGSC) under unbalanced grid voltage conditions. The behaviors of the DFIG SGSC during network unbalance are described. By injecting generated from to balance stator voltage, adverse effects upon DFIG, such as and rotor current unbalances, electromagnetic torque, power pulsations, can be removed, then conventional vector strategy...
Abstract Upper gastrointestinal (GI) hemorrhage is a common clinical emergency worldwide. Endoscopic hemostasis the current first line treatment. Nevertheless, for patients with severe active bleeding and challenging anatomy, endoscopic management can be still difficult usually requires higher level of surgical expertise. A simple effective method therefore in acute demand. Herein hemostatic hybrid hydrogel comprised hyaluronic acid polyethylene glycol stabilized by thiourea–catechol...
Stem cell therapy enhances healing of NSAID-related peptic ulcer through reducing inflammation and stimulating proliferation angiogenesis.
Abstract Background Endoscopic submucosal dissection (ESD) is the current standard treatment for early-stage esophageal neoplasms. However, postoperative stricture after extensive mucosal remains a severe challenge with limited effective treatments available. In this study, we introduced chitosan/gelatin (ChGel) sponge encapsulating adipose mesenchymal stem cells (ADMSCs)-derived exosomes (ChGel MSC−Exo ) prevention of stenosis ESD in porcine model. Results Pigs were randomly assigned into...
Rationale: Hyperactivation of HGF/MET signaling pathway is a critical driver in liver tumorigenesis. Cytochrome P450 1A2 (CYP1A2) was significantly down-regulated hepatocellular carcinoma (HCC). However, little explored about its tumor suppressive role HCC. In this study, we examined the functional mechanisms and clinical implication CYP1A2 Methods: The impact evaluated HCC patients Hong Kong cohort. biological functions were investigated vitro vivo. A series biochemical experiments...
Abstract Background Adenomyosis is a common gynecological disease, which accompanied by series of immunological and neuroendocrinological changes. Nerve growth factor (NGF) plays critical role in producing pain, neural plasticity, immunocyte aggregation release inflammatory factors. This study aimed to investigate the expression NGF its two receptors uteri dorsal root ganglia (DRG) an adenomyosis mouse model, as well their relationship with severity adenomyosis. Methods Forty newborn ICR...
Cerebral ischemia starts with cerebral blood flow interruption that causes severely limited oxygen and glucose supply, eliciting a cascade of pathological events, such as excitotoxicity, oxidative stress, calcium dysregulation, inflammatory response, which could ultimately result in neuronal death. Hirudin has beneficial effects ischemic stroke possesses antioxidant anti-inflammatory properties. Therefore, we investigated the biological functions hirudin its related mechanisms ischemia. The...
Hypertension is a serious chronic disease that can significantly lead to various cardiovascular diseases, affecting vital organs such as the heart, brain, and kidneys. Our goal predict risk of new onset hypertension using machine learning algorithms identify characteristics patients with hypertension. We analyzed data from 2011 China Health Nutrition Survey cohort individuals who were not hypertensive at baseline had follow-up results available for prediction by 2015. tested evaluated...
<title>Abstract</title> Minimally invasive interventions (MII) have revolutionized medical treatment by reducing patient trauma, speeding recovery, and improving surgical outcomes. However, conventional MII is often hindered challenges such as restricted tactile feedback in confined spaces, reliance on the surgeon's manual dexterity, dependence radiation-based imaging. The development of small-scale, soft robots capable performing via remote control, while integrating perception, real-time...
Objectives To investigate the relationship between endogenous androgens and body fat distribution in early late postmenopausal women. Materials Methods We enrolled women consisting of an group (≤5 years since menopause, n = 105) a (≥10 107). Each was subdivided into normal weight (BMI <24 kg/m2) group, overweight obese ≥24 group. Fasting total testosterone (T), dehydroepiandrosterone-sulfate (DHEA-S) sex hormone-binding globulin (SHBG) levels were measured. Body evaluated by dual-energy...
At present, a new algorithm of feature matching-SIFT has become hot topic in the matching field, whose ability is strong, and could process problems with translation, rotation affine transformation among different images, to certain extent more stable for images which are captured from random angles. In this paper, single camera first calibrated using plane chessboard based on OpenCV, order overcome shortcomings traditional previous self-calibration methods, SIFT proposed calibrate stereo...