A5112379253- Tryptophan and brain disorders
- Neurological Disease Mechanisms and Treatments
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Stress Responses and Cortisol
- Traditional Chinese Medicine Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Medical Research and Treatments
- Traditional Chinese Medicine Analysis
- Pharmacological Effects of Natural Compounds
- Neuroscience and Neuropharmacology Research
- Pediatric health and respiratory diseases
- Ginseng Biological Effects and Applications
- Flavonoids in Medical Research
- Natural product bioactivities and synthesis
- Biochemical effects in animals
- Sirtuins and Resveratrol in Medicine
- Food Quality and Safety Studies
- Phytoestrogen effects and research
- Autophagy in Disease and Therapy
- Metabolism, Diabetes, and Cancer
- Insect Resistance and Genetics
- Cancer-related molecular mechanisms research
- Seaweed-derived Bioactive Compounds
- Bone Metabolism and Diseases
First Affiliated Hospital of Henan University
2017-2025
Henan University of Traditional Chinese Medicine
2013-2025
Innovation Team (China)
2025
Lanzhou University
2024
China Academy of Chinese Medical Sciences
2024
First Hospital of Lanzhou University
2024
South China Normal University
2024
Air Force Medical University
2023
Xijing Hospital
2023
Henan University
2017
The present study aimed to evaluate the effects of paeoniflorin on insulin resistance and hepatic steatosis induced by fructose. Male Sprague-Dawley rats were fed 20% fructose drink for eight weeks. sensitivity, serum lipid profiles, lipids contents measured. results showed that significantly decreased glucagon levels, improved sensitivity alleviated in fructose-fed rats. Moreover, enhanced phosphorylation level AMP-activated protein kinase (AMPK) B (PKB/AKT) inhibited acetyl coenzyme A...
Myocardial ischemia/reperfusion (MI/R) injury, a major contributor to poor prognosis in patients with acute myocardial infarction, currently lacks effective therapeutic strategies clinical practice. The long noncoding RNA (lncRNA) Oip5-as1 can regulate various cellular processes, such as cell proliferation, differentiation, and survival. may have potential target for MI/R injury its upregulated expression has been associated reduced infarct size improved cardiac function animal models,...
The NLRP3 inflammasome is critically involved in the development of depression. E3 ubiquitin ligase TRIM31 negatively regulates this process by promoting degradation through ubiquitin-proteasome pathway. Modified Danzhi Xiaoyaosan (MDZXYS) has shown good therapeutic effect both preclinical and clinical depression treatments, yet underlying mechanisms its antidepressant effects are not fully understood. In present study, we aimed to explore MDZXYS, focusing on activation ubiquitin-mediated...
Introduction Dysfunction of axoplasmic transport is closely linked to depression. Baicalin, a major flavonoid in Scutellaria baicalensis , well-known traditional Chinese medicine used depression treatment, has demonstrated antidepressant-like effects previous studies. However, its potential role regulating not been explored. This study aims investigate the antidepressant mechanisms baicalin through modulation hippocampal neurons. Methods Male C57BL/6N mice were exposed chronic unpredictable...
Abstract Background The dysregulation of neuroinflammation triggered by imbalance microglia M1/M2 polarization is a key pathogenic factor and closely associated with occurrence depression. Formononetin (FMN), natural non-steroidal isoflavonoid, has been confirmed to exhibit remarkable anti-inflammatory efficacy, but the impact FMN on depression underlying antidepressant mechanisms are still not fully understood. This study aimed investigate whether effect involved in modulating polarization,...
To observe effect of sophora japonica total flavonoids on pancreas, kidney tissue morphology streptozotocin-induced diabetic mice model. Mice received tail vein injection streptozotocin (60 mg/kg) for diabetes modeling. The model were divided into five groups, to be respectively fed with high, middle and small doses solution, metformin solution saline the same volume. Another blank control group was set administered once a day 30 consecutive days, euthanatized after fasting blood glucose...
Background: Curcumin is a major active ingredient extracted from powdered dry rhizome of Curcuma longa.In Ayurveda and traditional Chinese medicine, it has been used as hepatoprotective agent for centuries.However, the underlying mechanisms are not clear. Objective: The present study to investigate effects curcumin in chronic alcohol-induced liver injury explore its mechanism. Design: Alcohol-exposed Balb/c mice were treated with (75 150 mg/kg) once per day 8 weeks. Tissue individual was...
Context Berberine is an alkaloid that possesses various pharmacologic effects.Objective To explore the mechanism of berberine to improve insulin sensitivity in fructose-fed mice.Materials and methods Sixty male ICR mice were randomly divided into 6 groups (10 each group): control, fructose, pioglitazone mg/kg) (50, 100, 200 mg/kg). Except for control group, received 20% fructose drinking 10 weeks. Pioglitazone orally administered once daily during last 4 The was evaluated using oral glucose...
In traditional Chinese medicine, the role of liver in depression is highly valued, and liver-relieving drugs, such as Sinisan, are often used to treat depression; however, mechanism whereby these drugs work remains unclear. The present study aimed reveal possible antidepressant mechanisms Sinisan (SNS) by analyzing hepatic proteomics chronic unpredictable mild stress (CUMS) mice. Using CUMS mouse model depression, effects SNS were assessed sucrose preference test (SPT) forced swimming (FST)....
Explore the possible protective effect of Sargentodoxa cuneata total phenolic acids on cerebral ischemia reperfusion injury rats. Focal rats model were established by linear thrombus. Nimodipine group, Naoluotong high, middle and low dose groups given related drugs via intragastric administration before operation for seven days, once a day. At same time sham group volume physiological saline. One hour after last administration, establish focal ischemia- in thread method, was taken out 2 h to...
To investigate the protective mechanism of verbenalin on cerebral ischemia-reperfusion injury. Middle artery occlusion in left hemisphere was induced rats by filament insertion, and rat model focal established. The high, medium low dose groups were injected tail vein corresponding drugs 10 min before reperfusion, submitted for 22 h reperfusion after operation. Mortality rate then calculated, neurological deficits scored. serum got to determine S-100β protein level, brain tissue removed...
To investigate the effect of curculigoside on mice with simulated perimenopausal depression.
Depression is a prevalent psychiatric disorder. Microglial state transition has been found in many neurological disorders including depression. Gypenosides (Gypenosides I-LXXVIII, Gps) are saponin extracts isolated from the traditional Chinese herb Gynostemma pentaphyllum (Thunb.) Makino that exert anti-inflammatory and neuroprotective activities regulate depression-like behaviors. However, its effect on microglial depression remains unknown. We aimed to evaluate potential relationship...