A5101718488- Sexual function and dysfunction studies
- Tryptophan and brain disorders
- Fire dynamics and safety research
- Combustion and Detonation Processes
- Nanoplatforms for cancer theranostics
- Photoacoustic and Ultrasonic Imaging
- Risk and Safety Analysis
- Ultrasound and Hyperthermia Applications
- Hormonal and reproductive studies
- Biochemical effects in animals
- Prenatal Substance Exposure Effects
- Mesenchymal stem cell research
- Tissue Engineering and Regenerative Medicine
- Sperm and Testicular Function
- Urinary Bladder and Prostate Research
- Assisted Reproductive Technology and Twin Pregnancy
- Liver physiology and pathology
- Genital Health and Disease
- Liver Disease Diagnosis and Treatment
- Stress Responses and Cortisol
- Nanoparticle-Based Drug Delivery
- Neuroscience and Neuropharmacology Research
- Traditional Chinese Medicine Studies
- Pharmacological Effects of Natural Compounds
- Marriage and Sexual Relationships
Shanxi Medical University
2025
Ningbo No. 2 Hospital
2024
Wuxi People's Hospital
2017-2024
Nanjing Medical University
2017-2024
Shuguang Hospital
2008-2024
Shanghai University of Traditional Chinese Medicine
2008-2024
Chongqing Medical University
2016-2023
Second Affiliated Hospital of Chongqing Medical University
2016-2023
Dalian Medical University
2016-2023
Xi'an University of Science and Technology
2022-2023
In this study, we successfully developed novel tumor homing-penetrating peptide-functionalized drug-loaded phase-transformation nanoparticles (tLyP-1-10-HCPT-PFP NPs) for low intensity focused ultrasound (LIFU)-assisted molecular imaging and precise therapy. With the nanoscale particle size, tLyP-1-10-HCPT-PFP NPs could pass through vascular endothelial cell gap. Induced by tLyP-1 peptide with targeting penetrating efficiency, increase accumulation penetrate deeply into extravascular tissue,...
Mesenchymal stem cells (MSCs) have been considered as an attractive tool for the therapy of diseases. Accumulating evidence indicates that healing effects MSCs are mainly related to paracrine action rather than transdifferentiation. Exosomes excreted from emerged physiologically relevant and powerful components MSC secretome. However, whether MSC-derived exosomes can improve erectile function streptozotocin-induced diabetic rats its mechanism remains unknown. Our previous work showed adipose...
Objective: Prepare a multifunctional ultrasound molecular probe, hyaluronic acid-mediated cell-penetrating peptide-modified 10-hydroxycamptothecin-loaded phase-transformation lipid nanoparticles (HA/CPPs-10-HCPT-NPs), and to combine HA/CPPs-10-HCPT-NPs with low-intensity focused (LIFU) for precision theranostics against hepatocellular carcinoma (HCC). Methods: were prepared using thin-film dispersion, emulsification, electrostatic effects. characterized particle size, zeta potential,...
Abstract Background Combined therapy based on the effects of cascade reactions nanoplatforms to combat specific solid tumor microenvironments is considered a cancer treatment strategy with transformative clinical value. Unfortunately, an insufficient O 2 supply and lack visual indication hinder further applications most for therapy. Results A visualizable nanoplatform liposome nanoparticles loaded GOD, H(Gd), PFP grafted peptide tLyP-1, named tLyP-1 H(Gd)-GOD@PFP, was constructed. The...
Erectile dysfunction (ED) is a major complication of diabetes, and many diabetic men with ED are refractory to common therapies. Adipose tissue-derived stem cells (ADSCs) have been shown improve erectile function in animal models. However, inadequate cell homing damaged sites has limited their efficacy. Therefore, we explored the effect ADSCs labeled superparamagnetic iron oxide nanoparticles (SPIONs) on improving streptozotocin-induced rats an external magnetic field. We found that SPIONs...
Cancer multidrug resistance (MDR) is an important reason that results in chemotherapy failure. As a main mechanism of MDR, overexpressed P-glycoprotein (P-gp) utilizes adenosine triphosphate (ATP) to actively pump drugs out cells. In addition, metabolic reprogramming drug-resistant tumor cells (DRTCs) exacerbates the specific hypoxic microenvironment and promotes metastasis recurrence. Therefore, we propose novel sonodynamic therapy (SDT) paradigm induce energy metabolism disorder drug...
Ulcerative colitis (UC) is a chronic inflammatory disease of the colonic mucosa with increasing incidence worldwide. Growing evidence highlights pivotal role nicotinamide adenine dinucleotide (NAD+) metabolism in UC pathogenesis, prompting our investigation into subtype-specific molecular underpinnings and diagnostic potential NAD+ metabolism-related genes (NMRGs). Transcriptome data from patients healthy controls were downloaded GEO database, specifically GSE75214 GSE87466. We performed...
The purpose of this study was to evaluate the predictors pregnancy outcome for infertile couples attending in vitro fertilisation (IVF) and intracytoplasmic sperm injection (ICSI) programmes. Infertile IVF or ICSI procedures were included study. Related data including semen parameters male female age body mass index collected analysed. main clinical pregnancy, defined as an ultrasound detection foetal heartbeat 6 weeks after embryo transfer. A total 1316 who underwent 266 recruited...
The activation of tunica albuginea myofibroblasts (MFs) serves an essential role in Peyronie's disease (PD). Increasing evidence has reported that adipose tissue‑derived stem cells (ADSCs) have been demonstrated to attenuate the symptoms PD animal models. However, mechanisms antifibrotic effects ADSCs remain be fully elucidated. In present study, inhibitory and possible mechanism on MFs derived from rat penile were investigated. obtained paratesticular fat Sprague Dawley rats. transformed...
Epalrestat, an aldose reductase inhibitor (ARI), was adopted to improve the function of peripheral nerves in diabetic patients. The aim this study investigate whether epalrestat could restore erectile dysfunction using a rat model. From June 2016, 24 rats were given streptozocin (STZ) induce model, and administered ten (DED) rats. Intracavernous pressure (ICP) mean systemic arterial (MAP), levels (AR), nerve growth factor (NGF), neuronal nitric oxide synthase (nNOS), α-smooth muscle antigen...
Abstract Adipose tissue-derived stem cells (ADSCs) have been shown to improve erectile function in animal models of dysfunction. However, few studies carried out using a reliable vivo imaging method trace transplanted real time, which is necessary for systematic investigation cell therapy. The study aims explore the feasibility non-invasively monitoring intracavernous injection ADSCs rat and miniature pig corpus cavernosum magnetic resonance (MR) imaging. Thirty-six male Sprague Dawley rats...
To compare effects of repairing injured tunica albuginea (PTA) rat penis by single or repeated local injections chlorhexidine ethanol (ChE) into the PTA and to establish a new animal model Peyronie's disease (PD).Forty-two rats were divided 7 groups. Rats either served as normal control group with 1-5 0.9% saline they received injection, 2, 3, 4, 5 ChE (0.1% gluconate plus 15% dissolved in saline); positive injected TGF-β1. At 60 days after last intracavernous pressure, degree penile...
Depression is gradually becoming a primary mental disease threatening human health. Therefore, there an urgent need to clarify the pathogenesis of depression and identify new effective natural antidepressants. This study aimed investigate antidepressant effects baicalin explore its potential mechanism in mouse model induced by chronic unpredictable mild stress (CUMS). Following 6-week exposure CUMS, mice were treated with (10 mg/kg) or fluoxetine for 4 weeks oral gavage. A sucrose preference...
// Jiqing Xuan 1, 2 , Yuli Chen 1 Leilei Zhu Yuan Guo Liming Deng Yuanyi Zheng 3 Zhaoxia Wang 4 Zhigang and Meng Ao Department of Ultrasound, The Second Affiliated Hospital Chongqing Medical University & Key Laboratory Ultrasound Molecular Imaging, 400010, China Southwest University, Luzhou, 646000, Institute in Medicine, Shanghai Jiaotong Sixth People’s Hospital, 200233, Children’s Correspondence to: Ao, email: aomeng735@163.com Wang, wzg62942443@163.com Keywords: poly...
Methylation modification is an important cellular mechanism of gene expression regulation. Dimethylarginine dimethylaminohydrolase-2 (DDAH-2) protein a pivotal molecular for endothelium function. To explore the effects 5-aza-deoxycytidine (5-aza), demethylation agent, in hyperhomocysteinemia (hhcy)-related erectile dysfunction (ED) rats, 5-aza (1 mg kg-1 ) was administrated to Sprague-Dawley hhcy-rats induced by supplemented methionine chow diet. Erectile function, nitric oxide-cyclic...