A5108065046- Wound Healing and Treatments
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Genetic and Kidney Cyst Diseases
- Mesenchymal stem cell research
- Neurological Complications and Syndromes
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Advanced Nanomaterials in Catalysis
- Hedgehog Signaling Pathway Studies
- Moyamoya disease diagnosis and treatment
- Circular RNAs in diseases
- Laser Applications in Dentistry and Medicine
- Diabetic Foot Ulcer Assessment and Management
- Sexual function and dysfunction studies
- Tendon Structure and Treatment
- Neuroinflammation and Neurodegeneration Mechanisms
- Metabolism, Diabetes, and Cancer
- Urinary Bladder and Prostate Research
- Genital Health and Disease
- Cancer, Hypoxia, and Metabolism
- Molecular Sensors and Ion Detection
- Epigenetics and DNA Methylation
- Flavonoids in Medical Research
Nanjing Drum Tower Hospital
2015-2025
Nanjing University of Chinese Medicine
2024
Nanjing Medical University
2011-2019
Mesenchymal stem cells (MSCs) have been considered as an attractive tool for the therapy of diseases. Accumulating evidence indicates that healing effects MSCs are mainly related to paracrine action rather than transdifferentiation. Exosomes excreted from emerged physiologically relevant and powerful components MSC secretome. However, whether MSC-derived exosomes can improve erectile function streptozotocin-induced diabetic rats its mechanism remains unknown. Our previous work showed adipose...
Extracellular matrix (ECM) and angiogenesis are critical controls of wound regeneration, their dysfunction delays diabetes recovery. CXXC5 belongs to the CXXC protein family that can regulate function human dermal fibroblasts (HDFs) umbilical vein endothelial cells (HUVECs); However, awareness its functional role remains limited. Mice were divided into control (CON), diabetic (DM), + KY19382 (DM KY19382), vehicle Vehicle) groups. HDFs HUVECs stimulated under different conditions mice treated...
The primary cilium is emerging as a crucial regulator of signaling pathways central to vertebrate development and human disease. We identified atrioventricular canal 1 (avc1), mouse mutation that caused VACTERL association with hydrocephalus, or VACTERL-H. showed avc1 hypomorphic intraflagellar transport protein 172 (Ift172), required for ciliogenesis Hedgehog (Hh) signaling. Phenotypically, VACTERL-H but not abnormalities in left–right (L–R) axis formation. Avc1 resulted structural cilia...
Fibroblast activation disorder is one of the main pathogenic characteristics diabetic wounds. Orchestrated fibroblast functions and myofibroblast differentiation are crucial for wound contracture extracellular matrix (ECM) formation. Pyruvate dehydrogenase kinase 4 (PDK4), a key enzyme regulating energy metabolism, has been implicated in modulating function, but its specific role wounds remains poorly understood. In this study, we investigated impact PDK4 on underlying mechanisms. To assess...
Diabetic ulcers (DUs) are a common and severe complication of diabetes, characterized by impaired wound healing due to complex pathophysiological mechanism. Elevated levels 11β-hydroxysteroid dehydrogenase type I (11β-HSD1) in wounds have been demonstrated modulate glucocorticoid activity, leading delayed skin cell proliferation restricted angiogenesis, ultimately hindering healing. In this study, we propose an electrospun poly(ε-caprolactone) (PCL) nanofiber scaffold doped with the 11β-HSD1...