A5075756432- Cancer, Lipids, and Metabolism
- Ubiquitin and proteasome pathways
- Sirtuins and Resveratrol in Medicine
- Ferroptosis and cancer prognosis
- Silymarin and Mushroom Poisoning
- Drug-Induced Hepatotoxicity and Protection
- Endoplasmic Reticulum Stress and Disease
- Histone Deacetylase Inhibitors Research
- Renin-Angiotensin System Studies
- Biochemical Acid Research Studies
- Adipose Tissue and Metabolism
- Granular flow and fluidized beds
- Cholesterol and Lipid Metabolism
- Heat shock proteins research
- PI3K/AKT/mTOR signaling in cancer
- Eicosanoids and Hypertension Pharmacology
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Autophagy in Disease and Therapy
- Particle Dynamics in Fluid Flows
- Neurological Disorders and Treatments
- Drug Transport and Resistance Mechanisms
- Sphingolipid Metabolism and Signaling
- Surface Modification and Superhydrophobicity
- Lipid metabolism and biosynthesis
Universität Innsbruck
2023-2025
University of Graz
2025
Shenzhen University
2018-2021
Shenzhen University Health Science Center
2018-2020
University of Kentucky
2018
Amsterdam UMC Location University of Amsterdam
2018
University of Amsterdam
2018
Jinan University
2018
Ionis Pharmaceuticals (United States)
2018
Erasmus MC
2018
Abstract Therapy resistance and metastasis, the most fatal steps in cancer, are often triggered by a (partial) activation of epithelial–mesenchymal transition (EMT) programme. A mesenchymal phenotype predisposes to ferroptosis, cell death pathway exerted an iron oxygen-radical-mediated peroxidation phospholipids containing polyunsaturated fatty acids. We here show that various forms EMT activation, including TGFβ stimulation acquired therapy resistance, increase ferroptosis susceptibility...
Abstract NAD+-dependent SIRT7 deacylase plays essential roles in ribosome biogenesis, stress response, genome integrity, metabolism and aging, while how it is transcriptionally regulated still largely unclear. TGF-β signaling highly conserved multicellular organisms, regulating cell growth, cancer stemness, migration invasion. Here, we demonstrate that histone deacetylase HDAC8 forms complex with SMAD3/4 heterotrimer occupies promoter, wherein deacetylates H4 thus suppresses transcription....
Abstract Dietary interventions such as intermittent fasting (IF) have emerged an attractive strategy for cancer therapies; therefore, understanding the underlying molecular mechanisms is pivotal. Here, we find SIRT7 decline markedly attenuates anti-tumor effect of IF. Mechanistically, AMP-activated protein kinase (AMPK) phosphorylating at T263 triggers further phosphorylation T255/S259 by glycogen synthase 3β (GSK3β), which stabilizes decoupling E3 ligase UBR5. hyperphosphorylation achieves...
Rationale: An elevated level of plasma LDL (low-density lipoprotein) is an established risk factor for cardiovascular disease. Recently, we reported that the (pro)renin receptor ([P]RR) regulates metabolism in vitro via LDLR (LDL receptor) and SORT1 (sortilin-1), independently renin–angiotensin system. Objectives: To investigate physiological role (P)RR lipid vivo. Methods Results: We used N-acetylgalactosamine modified antisense oligonucleotides to specifically inhibit hepatic expression...
Rationale:Silybum marianum is used to protect against degenerative liver damage. The molecular mechanisms of its bioactive component, silybin, remained enigmatic, although membrane-stabilizing properties, modulation membrane protein function, and metabolic regulation have been discussed for decades. Methods: Experiments were performed with hepatocyte cell lines primary monocytes in vitro under both basal stressed conditions, mice vivo. Quantitative lipidomics was detect changes phospholipids...
Abstract Cell death programs such as apoptosis and ferroptosis are associated with aberrant redox homeostasis linked to lipid metabolism membrane function. Evidence for cross-talk between these is emerging. Here, we show that cytotoxic stress channels polyunsaturated fatty acids via lysophospholipid acyltransferase 12 into phospholipids become susceptible peroxidation under additional stress. This reprogramming altered acyl-CoA synthetase isoenzyme expression caused by a decrease in growth...
Ferroptosis, a lipid peroxidation-driven cell death program kept in check by glutathione peroxidase 4 and endogenous redox cycles, promises access to novel strategies for treating therapy-resistant cancers. Chlorido [N,N'-disalicylidene-1,2-phenylenediamine]iron (III) complexes (SCs) have potent anti-cancer properties inducing ferroptosis, apoptosis, or necroptosis through still poorly understood molecular mechanisms. Here, we show that SCs preferentially induce ferroptosis over other...
Abstract Non-small cell lung cancer (NSCLC) is a deadly and highly prevalent malignancy. Targeting activated-EGFR mutations in NSCLC via EGFR tyrosine kinase inhibitor (EGFR-TKI) initially achieves profound therapeutic response, but resistance frequently evolves, reducing treatment options. Here, we present small-molecule compound D6 which selectively inhibits tumor growth migration cells with EGFR-TKI-resistant T790M-EGFR-activated (T790M-EGFR-AM), e.g., L858R/T790M, 19Del/T790M...
Abstract SIRT7 plays critical roles in tumorigenesis and tumor progression; however, the underlying mechanisms are poorly understood. Here, we aimed to identify downstream targets of help delineate its precise function. In this study, demonstrate that is essential regulate IDH1 expression various cancer cell types. Interestingly, both levels downregulated breast lung metastases useful for predicting disease progression prognosis. Mechanistically, enhances transcription, process mediated by...
Abstract Silybum marianum is used to protect against degenerative liver damage. The molecular mechanisms of its bioactive component, silybin, remained enigmatic, although membrane-stabilizing properties, modulation membrane protein function, and metabolic regulation have been discussed for decades. Here, we show that specifically the stereoisomer silybin A decreases triglyceride levels lipid droplet content, while enriching major phospholipid classes maintaining a homeostatic composition in...