A5101718792- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Fungal Biology and Applications
- Phytochemistry and Bioactivity Studies
- Natural product bioactivities and synthesis
- Chemical synthesis and alkaloids
- Phytochemistry and Biological Activities
- Plant biochemistry and biosynthesis
- Crystallography and molecular interactions
- Phytochemistry and Bioactive Compounds
- Ginger and Zingiberaceae research
- Phytochemical compounds biological activities
- Phytochemicals and Antioxidant Activities
- Pharmacological Effects of Medicinal Plants
- Microbial Natural Products and Biosynthesis
- Medicinal plant effects and applications
- Plant chemical constituents analysis
- Sesquiterpenes and Asteraceae Studies
- Biological Activity of Diterpenoids and Biflavonoids
- Wood and Agarwood Research
- Bone Metabolism and Diseases
- Natural Antidiabetic Agents Studies
- Insect Utilization and Effects
- Traditional and Medicinal Uses of Annonaceae
- Plant-derived Lignans Synthesis and Bioactivity
Shenzhen University
2020-2025
Guangdong Pharmaceutical University
2020-2025
Shenzhen University Health Science Center
2017-2024
Hanshan Normal University
2021-2023
Lanzhou University
2022
Kunming Institute of Botany
2010-2021
Chinese Academy of Sciences
2008-2019
Henan University of Traditional Chinese Medicine
2015-2018
First Affiliated Hospital of Henan University
2018
Yunnan University of Traditional Chinese Medicine
2018
Applanatumin A (1), a novel meroterpenoid dimer, was isolated from the fungus Ganoderma applanatum. Its structure and absolute configuration were assigned on basis of spectroscopic computational data. Notably, 1 possesses new hexacyclic skeleton containing spiro[benzofuran-2,1'-cyclopentane] motif. plausible pathway, involving key Diels-Alder reaction, is proposed for biosynthesis 1. exhibits potent antifibrotic activity in TGF-β1-induced human renal proximal tubular cells.
Abstract NAD+-dependent SIRT7 deacylase plays essential roles in ribosome biogenesis, stress response, genome integrity, metabolism and aging, while how it is transcriptionally regulated still largely unclear. TGF-β signaling highly conserved multicellular organisms, regulating cell growth, cancer stemness, migration invasion. Here, we demonstrate that histone deacetylase HDAC8 forms complex with SMAD3/4 heterotrimer occupies promoter, wherein deacetylates H4 thus suppresses transcription....
Multidrug resistance in pancreatic cancer poses a significant challenge clinical treatment. Bufalin (BA), compound found secretions from the glands of toads, may help overcome this problem. However, severe cardiotoxicity thus far has hindered its application. Hence, present study aimed to develop cell membrane-camouflaged and BA-loaded polylactic-co-glycolic acid nanoparticle (CBAP) assess potential counter chemoresistance cancer.The toxicity CBAP was evaluated by electrocardiogram, body...
(+)- and (−)-Sinensilactam A (1), novel hybrid metabolites possessing a unique 2H-pyrrolo[2,1-b][1,3]oxazin-6(7H)-one ring system, were isolated from the fruit bodies of Ganoderma sinensis. The structures these substances absolute configurations at their stereocenters assigned using spectroscopic computational methods along with X-ray crystallographic analysis. plausible pathway for biosynthesis 1 is proposed. (−)-1 was found to be Smad3 phosphorylation inhibitor in TGF-β1 induced human...
Spiroapplanatumines A–Q (1–12, 14–16, 18, and 20), new spiro meroterpenoids respectively bearing a 6/5/7 or 6/5/5 ring system, along with three known compounds, spirolingzhines A, B, D, were isolated from the fruiting bodies of fungus Ganoderma applanatum. Their structures including absolute configurations assigned by using spectroscopic methods, ECD 13C NMR calculations, single-crystal X-ray diffraction analysis. Biological evaluation all compounds disclosed that 7 8 inhibited JAK3 kinase...
T-type calcium channel (TTCC) inhibitors hold great potential for the treatment of a variety neurological disorders. Cochlearoids A–E (1–5), five pairs dimeric meroterpenoid enantiomers, and cochlearines A (6) B (7), two enantiomeric hybrid metabolites, were isolated characterized from Ganoderma cochlear. Biological evaluation found that compounds (+)-1, (−)-3, (±)-6 significantly inhibited Cav3.1 TTCC showed noticeable selectivity against Cav1.2, Cav2.1, Cav2.2, Kv11.1 (hERG) channels.
Five undescribed polyprenylated xanthones (1, 3, 4, 22, and 23) 27 known compounds were isolated from Garcinia resins, the antifungal activities of 15 them investigated. Compound 7 exhibited notable in vitro effects against Magnaporthe grisea with an IC50 value 3.54 μg/mL, superior to isoprothiolane (10.30 μg/mL), showed excellent protective efficiency 78.4% at 200 μg/mL RB (rice blast), equivalent (87.2%). Its activity may be related destruction cell membrane effect absorption utilization...
Twelve guanidine derivatives (1-12), including seven new compounds (martensiiagms A-G, 1-7), one hypoxanthine derivative (martensiiagm H, 13), and 15 known (14-28) were isolated from the whole body of Buthus martensii Karsch identified by analysis data. Subsequent biological evaluations revealed anti-inflammatory activity compound 1. It attenuates neuroinflammation oxidative stress levels prompted lipopolysaccharide. This attenuation is accomplished a specific action on mitochondria, which,...
Concise synthesis of (±)-Lingzhiol has been achieved.
Applanatumols A (<bold>1</bold>) and B [(±)-<bold>2</bold>], two unique meroterpenoids with a novel spiro[benzofuran-2,2′-bicyclo[3.2.2]nonane] ring system naturally unusual dioxacyclopenta[<italic>cd</italic>]inden motif, respectively, were isolated from <italic>Ganoderma applanatum</italic>.
Radix Rehmanniae (RR) is a kind of herb which widely used in the clinical and food processing industry. There are four forms RR traditional Chinese medicine practice, include fresh (FRR), raw (RRR), processed (PRR), another (APRR), APRR was by nine cycles repeated steaming drying. large number saccharides RR. However, differences content were shown different methods. In this study, an effective method using high-performance liquid chromatography (HPLC) chromatography-mass spectrometry...
Ganotheaecolin A (1), a novel ergosterol with rare naphtho[1,8-ef]azulene ring system, was isolated from the fruiting bodies of Ganoderma theaecolum. Its structure determined by spectroscopic data and computational methods. Compound 1 represents 6/6/7/5-fused carbon skeletal typically formed Wagner–Meerwein rearrangement, whose plausible biosynthetic pathway briefly discussed. Finally, neurotrophic activity examined using PC12 cells.
(±)-Lucidumone (1), an enantiomeric meroterpenoid possessing unprecedented skeleton comprising a fused 6/5/6/6/5 polycyclic system, was isolated from Ganoderma lucidum and structurally identified. The absolute configuration of (−)-1 assigned by single-crystal X-ray crystallography. A plausible biosynthetic pathway for 1 is proposed. chemical biology approach reveals that selectively inhibits COX-2 directly binding with amino acid residue Tyr385, representing new structure scaffold inhibitors.
The transforming growth factor β (TGFβ) and bone morphogenetic protein (BMP) signaling pathways are both constitutively activated in triple-negative breast cancer (TNBC). We interested isolating the naturally-derived small-molecule inhibitor that could simultaneously targeting TGFβ/BMP further studying its anti-proliferative/−metastatic effects as well underlying mechanisms multiple tumor models. Multiple vitro cell-based assays used to examine compound's inhibitory efficacy on TNBC cell...
Aspongdopamines A and B (1 2), unusual adducts composed of N-acetyldopamine adenine were isolated from the insect Aspongopus chinensis. Compounds 1 2 are positional isomers both as racemates. Chiral separation assisted by 14-step total synthesis computation including vibrational circular dichroism calculations allowed us to unambiguously assign absolute configurations eight stereoisomers. Renal fibrosis inhibition stereoisomers was evaluated in TGF-β1-induced rat kidney epithelial cells.
Aquilarines A (1) and B (2), two unprecedented sesquiterpenoid-chromone heterohybrids, were isolated from Aquilaria sinensis agarwood. 1 is an alkaloid featuring unusual pyridine nucleus, 2 possesses a rare skeleton via C–C bond. plausible biosynthetic pathway for was proposed. Both could significantly inhibit the expression of extracellular matrix components, α-SMA at low concentrations in TGF-β1 induced types kidney cells (NRK 52E NRK 49F) selective inhibition Smad3 instead Smad2...
Aquilariperoxide A (1), an unprecedented sesquiterpene dimer characterized by a dioxepane ring connecting two units via C-C bond, was isolated from agarwood of Aquilaria sinensis-containing resins. The structure elucidated spectroscopic and computational methods. bioassay revealed that 1 significantly inhibits cell proliferation migration in human cancer cells. mechanism against cells briefly discussed analysis RNA sequence data epithelial-mesenchymal transition. Besides, the antimalarial...
A new pyridone alkaloid, (+)-N-deoxymilitarinone (1), was isolated from Paecilomyces farinosus RCEF 0097 along with the related metabolites, militarinone D and B. The sterol 22E,4R-ergosta-7,22-diene-3β,5α,6β,9α-tetraol also identified. structures were established by spectroscopic methods, in particular aid of extensive NMR experiments. Compound 1 induced neurite sprouting PC 12 cells when tested at 33 100 μM concentrations. cytotoxic effect observed human neurons (IMR-32) a concentration μM.