A5102003531- Radical Photochemical Reactions
- Sulfur-Based Synthesis Techniques
- Plant Pathogens and Resistance
- Cellular and Composite Structures
- Plant Disease Resistance and Genetics
- Crystallization and Solubility Studies
- Cellular Mechanics and Interactions
- Skin and Cellular Biology Research
- Catalytic C–H Functionalization Methods
- Wound Healing and Treatments
- Diabetes Treatment and Management
- Organic and Inorganic Chemical Reactions
- Plant-Microbe Interactions and Immunity
- X-ray Diffraction in Crystallography
- Potato Plant Research
- Gastric Cancer Management and Outcomes
- Topology Optimization in Engineering
- High voltage insulation and dielectric phenomena
- Laser and Thermal Forming Techniques
- Icing and De-icing Technologies
- Apelin-related biomedical research
- Chemical synthesis and alkaloids
- Medicinal Plants and Neuroprotection
- Cyclopropane Reaction Mechanisms
- Electrolyte and hormonal disorders
Chongqing University
2022-2025
Daping Hospital
2023-2025
Army Medical University
2023-2025
Northeastern University
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2024
Central China Normal University
2023-2024
Anhui Normal University
2023
Phytophthora infestans, the notorious pathogen of potato late blight, leads to a severe decline in yields and even harvest failure. We isolated 201 endophytic isolates from healthy root tissues potatoes, among which 41 showed strong antagonistic activity against P. infestans. Further, tolerance stress potential application blight these were tested. Most them extremely tolerant stresses such as acid-alkali, temperature, UV, salt, heavy metal stress. However, some with excellent might be...
Abstract Sultines (lactones of sulfinic acids), as a fascinating class sulfur heterocycles, has been found tremendous applications in the field chemistry, pharmaceutical, and materials sciences due to unique chemical, biological, pharmaceutical activities. However, chemistry sultines long remains less developed because their challenging access with traditional routes. The recent years have witnessed an increasing interest preparation new methods were reported modern methodologies...
Late blight, caused by Phytophthora infestans, is one of the most destructive diseases in potato cultivation. Chemical fungicides are currently primary means controlling it, but they pose significant issues, including environmental pollution and development resistant strains. Plant jiaosu (PJ), derived from direct fermentation various plants, plays a vital part fields such as protection, agriculture, daily chemicals, livestock. This study illustrates that PJ, fermented lettuce leaves,...
BACKGROUND: Vascular remodeling characterized by vascular smooth muscle cell (VSMC) phenotypic switching is a key pathological process leading to numerous cardiovascular diseases, often accompanied decrease in mitochondrial oxidative phosphorylation. However, whether VSMC homeostasis plays central role remains elusive. In this study, we investigated the of SIRT3 (sirtuin 3), deacetylase that maintains homeostasis, remodeling. METHODS: We established VSMC-specific knockout mouse and...
Molecules with precise sultine structures are particularly sought after since the function of a molecule depends on this interesting structure. Despite positive pivotal significance sultines in synthesis, medicine, and materials science, sultines' chemistry long remains unexplored due to their inaccessibility; only very limited protocols have been developed. Here, we report an energy-transfer-powered intramolecular radical–radical cross-coupling cyclization for practical atom-economical...
To identify risk factors predictive of or associated with gastrointestinal side effects (GISE) liraglutide in patients type 2 diabetes (T2DM).T2DM treated for the first time were obtained and grouped into without GSEA GSEA. Baseline variables, including age, sex, body mass index (BMI), glycemia profiles, alanine aminotransferase, serum creatinine, thyroid hormones, oral hypoglycemic drugs history diseases, tested possible associations outcome. Significant variables entered univariate...
Phytophthora infestans causes late blight, threatening potato production. The tropane alkaloid scopolamine from some industrial plants (Datura, Atropa, etc.) has a broad-spectrum bacteriostatic effect, but its effect on P. is unknown.In the present study, inhibited mycelial growth of phytopathogenic oomycete infestans, and half-maximal inhibitory concentration (IC50 ) was 4.25 g L-1 . sporangia germination rates were 61.43%, 16.16%, 3.99% at concentrations zero (control), 0.5 IC50 ,...
ABSTRACT Aims To examine whether sublingual microcirculation can be used as an effective and noninvasive method for assessing cardiovascular, kidney, metabolic risks in patients with type 2 diabetes mellitus (T2DM). Materials Methods This cross‐sectional observational study enrolled 186 T2DM. All were evaluated using the Framingham General Cardiovascular Risk Score (FGCRS) cardiovascular‐kidney‐metabolic (CKM) syndrome stage. Side‐stream dark‐field microscopy was microcirculation, including...
A thermoinduced radical homolytic substitution cyclization of alkenyl tethered sulfinate esters was displayed under mild metal-free conditions, enabling the functionalization alkenes and leading to structurally diverse value-added sultine products. The process utilizes readily available substrates using inexpensive 5% benzoyl peroxide (BPO) as an initiator generate functionalized sultines with broad functional group tolerance in medium excellent yields a highly atom-economical manner. In...
The applications of triply periodic minimum surfaces (TPMS) in biomedicine, aerospace and functionally graded materials have garnered significant interest. In order to further explore the possibility regulating properties TPMS-based lattice structures, radial-graded Gyroid structures (GLSs) were constructed Al–Si10–Mg samples prepared by selective laser melting (SLM). FEA compression experiments employed evaluate deformation behavior, mechanical response energy absorption GLSs. introduction...
An asymmetric and highly practical thiosulfinylation of alkynes is established for the synthesis sultim derivatives. The disclosed platform featured broad substrate scope group tolerance diverse biologically important molecules under mild operationally simple conditions. Notably, obtained chiral sulfinyl derivatives have demonstrated their potential application in further gram-scale product derivatizations, providing a chance drug discovery.
Late blight, caused by Phytophthora infestans, is a devastating disease of potato. Our previous work illustrated that scopolamine, the main bioactive substance Datura extract, exerts direct inhibitory effects on P. but it unclear whether scopolamine and extract can boost resistance to late blight in In this study, infestans used infect scopolamine-treated potato pieces leaves, as well whole potatoes. We found resistant both vitro vivo. The treatment 4.5 g/L reduces lesion size 54% compared...
Potato late blight, caused by Phytophthora infestans, leads to a significant reduction in the yield and value of potato. Biocontrol displays great potential suppression plant diseases. Diallyl trisulfide (DATS) is well-known natural compound for biocontrol, although there little information about it against potato blight. In this study, DATS was found be able inhibit hyphae growth P. reduce its pathogenicity on detached leaves tubers, induce overall resistance tubers. significantly increases...
Cutaneous wound healing is a fundamental biological and coordinated process, failure to maintain this process contributes the dysfunction of tissue homeostasis, increasing global burden diabetic foot ulcerations. However, factors that mediate are not fully understood. Here, we identify dedicator cytokinesis 5 (Dock5) pivotal role in keratinocyte functions contributing skin healing. Specifically, Dock5 highly upregulated during proliferative phase repair predominantly expressed epidermal...
Objectiv: Salt-sensitive hypertension is highly prevalent and associated with cardiorenal damage. Large clinical trials have demonstrated that Sodium-glucose cotransporter 2 (SGLT2) inhibitors exert hypotensive effect protective benefits in hypertensive patients without diabetes. However, the underlying mechanism remains elusive. Methods: Dahl salt-sensitive (SS) rats salt-insensitive controls were fed 8% high salt diet to establish model, some of them treated canagliflozin. The blood...
A Friedel–Crafts addition/oxidation/Schiff-base condensation tandem reaction for the synthesis of planar indolizine-fused azepines is described.