A5102947869- Bipolar Disorder and Treatment
- Functional Brain Connectivity Studies
- Mental Health Research Topics
- Advanced Neuroimaging Techniques and Applications
- Psychosomatic Disorders and Their Treatments
- Tryptophan and brain disorders
- Maternal Mental Health During Pregnancy and Postpartum
- Genetics and Neurodevelopmental Disorders
- Ion channel regulation and function
- Plant-Microbe Interactions and Immunity
- Plant Disease Resistance and Genetics
- Neurological disorders and treatments
- Neuroscience of respiration and sleep
- Schizophrenia research and treatment
- Child and Adolescent Psychosocial and Emotional Development
- Attention Deficit Hyperactivity Disorder
- Obstructive Sleep Apnea Research
- Suicide and Self-Harm Studies
- Neural and Behavioral Psychology Studies
- Sleep and Wakefulness Research
- Neural dynamics and brain function
- Adolescent and Pediatric Healthcare
- Plant Pathogens and Resistance
Guangzhou Medical University
2016-2025
University of Toronto
2024
V.F. Corporation (United States)
2024
Nanjing Brain Hospital
2024
Nanjing Medical University
2024
Bridge Pharma (United States)
2024
CTS Corporation (Czechia)
2024
Chinese University of Hong Kong
2024
Chongqing University
2023
Major depressive disorder (MDD) is one of the most prevalent mental disorders. In brain, hubs brain network play a key role in integrating and transferring information between different functional modules. However, whether changed pattern contributes to onset MDD remains unclear. Using resting-state magnetic resonance imaging graph theory methods, we investigated alterations can be detected MDD. First, constructed whole-brain voxel-wise networks calculated connectivity strength (FCS) map...
Rumination is a central feature of major depressive disorder (MDD). Knowledge the neural structures that underpin rumination offers significant insight into pathophysiology and may help to develop potential intervention strategies for MDD, mental illness has become leading cause disability worldwide.Using resting-state fMRI graph theory, this study adopted connectome approach examine functional topological organization network associated with in MDD. Data from 96 participants were analyzed,...
Obstructive sleep apnea (OSA) is linked to brain alterations, but the specific regions affected and causal associations between these changes remain unclear. We studied 20 pairs of age-, sex-, BMI-, education- matched OSA patients healthy controls using multimodal magnetic resonance imaging (MRI) from August 2019 February 2020. Additionally, large-scale Mendelian randomization analyses were performed genome-wide association study (GWAS) data on 3935 imaging-derived phenotypes (IDPs),...
Delayed diagnosis of bipolar disorder (BD) is common. However, diagnostic validity may be enhanced using reliable neurobiological markers for BD. Degree centrality (DC) one such potential marker that enables researchers to visualize neuronal network abnormalities in the early stages some neuropsychiatric disorders. In present study, we measured resting-state DC and cognitive deficits order identify We recruited 23 patients with BD who had recently experienced manic episodes (duration illness...
Abstract Aerobic exercise is effective in alleviating mood symptoms while the mechanism poorly understood. There are limited clinical trials that investigated effect of on anterior cingulate cortex (ACC), a key brain region involved regulations, adolescents with subthreshold syndromes. This randomized controlled trial (RCT) aerobic was undertaken middle school Guangzhou, China. Participants were aged 12–14 syndromes including depressive and manic randomly assigned to an intervention or...
Bipolar I disorder (BD-I) is associated with a high risk of suicide attempt; however, the neural circuit dysfunction that confers suicidal vulnerability in individuals this remains largely unknown. Resting-state functional magnetic resonance imaging (rs-fMRI) allows non-invasive mapping brain connectivity. The current study used an unbiased voxel-based graph theory analysis rs-fMRI to investigate intrinsic networks BD-I patients and without attempt.A total 30 attempt (attempter group), 82...
Patients with Bipolar Disorder (BD) are associated aberrant uncinate fasciculus (UF) that connects amygdala-ventral prefrontal cortex (vPFC) system, but the casual relationship is still uncertain. The research aimed to investigate integrity of UF among offspring patients BD and its potential causal association subsequent declaration BD. fractional anisotropy (FA) mean diffusivity (MD) were compared in asymptomatic (AO, n = 46) symptomatic (SO, 45) a parent BD, age-matched healthy controls...
Abstract Background Bipolar Disorder (BD), a severe neuropsychiatric condition, often manifests during adolescence. Traditional diagnostic methods, relying predominantly on clinical interviews and symptom assessments, may fall short in accuracy, especially when based solely single-modal MRI techniques. Objective This study aims to bridge the gap adolescent BD by integrating behavioral assessments with multimodal approach. We hypothesize that this combination will enhance accuracy of...
Phytophthora infestans causes late blight, threatening potato production. The tropane alkaloid scopolamine from some industrial plants (Datura, Atropa, etc.) has a broad-spectrum bacteriostatic effect, but its effect on P. is unknown.In the present study, inhibited mycelial growth of phytopathogenic oomycete infestans, and half-maximal inhibitory concentration (IC50 ) was 4.25 g L-1 . sporangia germination rates were 61.43%, 16.16%, 3.99% at concentrations zero (control), 0.5 IC50 ,...
Background: Bipolar disorder (BD) is a highly heritable mood disorder. Activated low-grade inflammation may not only play an adverse role in the pathophysiology of BD, but also contribute to resilience process. The neuroinflammatory processes underlie attention deficit and alteration gray matter volume (GMV) early stage premorbid period BD. Also, differential inflammation-brain relationship be identified as biological markers for BD pathology or resilience.Methods: present data were...
Objective To explore the functional connectivity alterations in patients with schizophrenia and bipolar disorder. Methods Resting-state magnetic resonance imaging data were collected from 22 who meet diagnosis criteria of mania DSM-IV, DSM-IV normal controls. Default mode network was reconstructed using seed-based approach comparison done. The association strength clinical measures also examined. Results (1) Compared to controls, showed increased within cortical midline...
Objective To explore the small world characters of patients in early stage bipolar disorder by using graph theory. Methods Resting-state fMRI data were collected from 22 who met with DSM-IV diagnostic criteria for current manic episode and duration less than 2 years, age- gender-matched healthy control subject. Time series AAL 90 regions extracted each subject correlation matrices analyzed. Results Compared health controls, showed significantly decreased global efficiency...