A5059039565- Wheat and Barley Genetics and Pathology
- Plant Disease Resistance and Genetics
- Bipolar Disorder and Treatment
- Functional Brain Connectivity Studies
- Advanced Neuroimaging Techniques and Applications
- Parkinson's Disease Mechanisms and Treatments
- Chromosomal and Genetic Variations
- Immunotherapy and Immune Responses
- Neurological disorders and treatments
- Neuroscience and Neuropharmacology Research
- Advanced oxidation water treatment
- Natural Compound Pharmacology Studies
- Alzheimer's disease research and treatments
- Fluoride Effects and Removal
- Immune Cell Function and Interaction
- Radiomics and Machine Learning in Medical Imaging
- Insect symbiosis and bacterial influences
- Sleep and Wakefulness Research
- Mental Health Research Topics
- Maternal Mental Health During Pregnancy and Postpartum
- Genomics and Phylogenetic Studies
- Chemokine receptors and signaling
- Cholinesterase and Neurodegenerative Diseases
- Autophagy in Disease and Therapy
- Selenium in Biological Systems
Guangzhou Medical University
2016-2024
Northwest A&F University
2021-2024
Sun Yat-sen University
2024
Fudan University
2018-2024
Zhongshan Hospital
2024
The First Affiliated Hospital, Sun Yat-sen University
2024
Army Medical University
2013-2023
Shanxi Agricultural University
2018-2022
First Affiliated Hospital of Jinan University
2020-2022
Guangzhou Psychiatric Hospital
2022
A close view of the paraventricular thalamus The is a relay station connecting brainstem and hypothalamic signals that represent internal states with limbic forebrain performs associative functions in emotional contexts. Zhu et al. found thalamic neurons multiple salient features sensory stimuli, including reward, aversiveness, novelty, surprise. nucleus thus provides context-dependent salience encoding. gates information contributes to sleep-wake cycle through its interactions cerebral...
Cerebral energy metabolism in Alzheimer disease (AD) has recently been given increasing attention. This study focuses on the alterations of cerebral lactate double-transgenic amyloid precursor protein/presenilin 1 (APP/PS1) mouse model AD. Immunofluorescence staining and Western blotting analysis were used to identify content transporters (MCT1, MCT2, MCT4) APP/PS1 brains, which display beta plaques, reduced amounts neurons oligodendrocytes, increased quantity astrocytes. We found that...
The autophagy receptor CALCOCO2/NDP52 functions as a bridging adaptor and plays an essential role in the selective autophagic degradation of invading pathogens by specifically recognizing ubiquitin-coated intracellular subsequently targeting them to machinery; thereby it is required for innate immune defense against range infectious mammals. However, mechanistic basis underlying CALCOCO2-mediated specific recognition ubiqutinated still unknown. Here, using biochemical structural analyses, we...
To accurately prevent and warn of traffic accidents, this article proposes a method for predicting urban road safety risks based on vehicle driving behaviour data information entropy theory. This uses from radar video-integrated sensors to calibrate the thresholds identifying unsafe behaviour, introduces recognition principles algorithms, analyses spatiotemporal distribution patterns. By incorporating theory, an evaluation system with as primary indicator rate secondary is established....
TiO(2) photocatalytic oxidation (PCO) of As(III) in the normal air-saturated aqueous solutions has been widely studied. Yet no consensus achieved on mechanism whether superoxide is main oxidant, although many approaches have taken. (Photo)electrochemical method can minimize changes to surface and could therefore not alter mechanism. In this Article, both approach kinetic measurements were performed clarify disputed Under a sufficient cathodic bias potential, dark by occur, but reaction rate...
Allergic asthma is a chronic inflammatory disease primarily mediated by Th2 immune mechanisms. Numerous studies have suggested that early life exposure to lipopolysaccharide (LPS) negatively associated with allergic asthma. One proposed mechanism invokes desensitization of lung epithelial cells LPS. We report here acyloxyacyl hydrolase (AOAH), host lipase degrades and inactivates LPS, renders mice more susceptible house dust mite (HDM)-induced Lung from Aoah-/- are refractory HDM...
FYCO1 (FYVE and coiled-coil domain containing 1) functions as an autophagy adaptor in directly linking autophagosomes with the microtubule-based kinesin motor, plays essential role microtubule plus end-directed transport of autophagic vesicles. The specific association is mediated by its interaction Atg8-family proteins decorated on outer surface autophagosome. However, mechanistic basis governing between largely unknown. Here, using biochemical structural analyses, we demonstrated that...
This study was conducted to investigate the effect and underlying mechanism of Resveratrol (RES) in regulating skeletal muscle fiber-type switching.
Altered cytokine production has been implicated in the down-regulation of cell-mediated immunity mice bearing large mammary tumors. In several diseases, an imbalance between helper T lymphocytes Th1 and Th2 their cytokines suggested as a contributing factor. this study, although IFN-gamma from splenic cells D1-DMBA-3 tumor-bearing was greatly diminished, other levels remained unchanged, indicating no clear shift Th1, Th2, or Th3 phenotypes. The can be restored vitro by addition rIL-12 to...
Abstract The diagnosis and pathology of neuropsychiatric systemic lupus erythematosus (NPSLE) remains challenging. Herein, we used multimodal imaging to assess anatomical functional changes in brains SLE patients instead a single MRI approach generally previous studies. Twenty-two NPSLE patients, 21 non-NPSLE 20 healthy controls (HCs) underwent 3.0 T with multivoxel magnetic resonance spectroscopy, T1-weighted volumetric images for voxel based morphometry (VBM) diffusional kurtosis (DKI)...
Bipolar I disorder (BD-I) is associated with a high risk of suicide attempt; however, the neural circuit dysfunction that confers suicidal vulnerability in individuals this remains largely unknown. Resting-state functional magnetic resonance imaging (rs-fMRI) allows non-invasive mapping brain connectivity. The current study used an unbiased voxel-based graph theory analysis rs-fMRI to investigate intrinsic networks BD-I patients and without attempt.A total 30 attempt (attempter group), 82...
Video-assisted thoracic surgery (VATS) is a minimally invasive technique for the diagnosis and management of small pulmonary nodular lesions However, identification some lung nodules remains difficult.This research aimed to investigate clinical value preoperative computed tomography (CT)-guided hookwire localization solitary (SPNs) thoracoscopic resection.Seventy-one patients with 74 SPNs underwent VATS wedge resection after CT-guided localization. The mean diameter was 8.50 ± 4.53...
Lymphangiogenesis is one of the promoters tumor lymphatic metastasis. Fucoidan which a fucose-enriched sulfated polysaccharide has effect on various pharmacological activities including anti-metastasis activity. However, inhibitory fucoidan lymphangiogenesis remains unclear. Here, extracted from U. pinnatifida sporophylls suppressed HLECs proliferation, migration and tube-like structure formation, had tumor-induced in vitro. Additionally, we found that dose-dependent depressive expressions...
The steviol glycosides (SGs) in stevia (Stevia rebaudiana Bertoni) leaves are becoming increasingly valuable due to its high sweetness but low calorific value, which is driving the development of commercial cultivation. Optimizing fertilization management can effectively increase SGs productivity, knowledge on relationship between potassium (K) and production still lacking. In this study, pot experiments were conducted order investigate effect K deficiency synthesis leaves, as well...