A5046056423- Plant Molecular Biology Research
- Plant Virus Research Studies
- Plant Gene Expression Analysis
- Biochemical Analysis and Sensing Techniques
- Epigenetics and DNA Methylation
- Research in Cotton Cultivation
- Plant tissue culture and regeneration
- RNA modifications and cancer
- Plant responses to water stress
- Plant nutrient uptake and metabolism
- Cancer-related gene regulation
- Plant-Microbe Interactions and Immunity
- Transgenic Plants and Applications
- RNA and protein synthesis mechanisms
- Polysaccharides and Plant Cell Walls
- Galectins and Cancer Biology
- Brucella: diagnosis, epidemiology, treatment
- Toxin Mechanisms and Immunotoxins
- Chromatin Remodeling and Cancer
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Lung Cancer Treatments and Mutations
- Circular RNAs in diseases
- Ferroptosis and cancer prognosis
- PARP inhibition in cancer therapy
Chinese Academy of Sciences
2018-2024
Institute of Botany
2018-2024
Shandong Agricultural University
2023
Jiangsu University
2022-2023
Fourth Affiliated Hospital of China Medical University
2014-2022
China Medical University
2013-2022
Binzhou Medical University
2019-2022
Binzhou University
2019-2022
Institute of Soil and Water Conservation
2022
Northwest A&F University
2022
Two draft sequences of Gossypium hirsutum, the most widely cultivated cotton species, provide insights into genome structure, rearrangement, gene evolution and fiber biology. Upland is a model for polyploid crop domestication transgenic improvement. Here we sequenced allotetraploid hirsutum L. acc. TM-1 by integrating whole-genome shotgun reads, bacterial artificial chromosome (BAC)-end genotype-by-sequencing genetic maps. We assembled annotated 32,032 A-subgenome genes 34,402 D-subgenome...
Sucrose synthase (SUS) is widely considered a key enzyme participating in sucrose metabolism higher plants and regarded as biochemical marker for sink strength crops. However, despite significant progress characterizing the physiological functions of SUS gene family, knowledge trajectory evolutionary processes significance family remains incomplete.In this study, we identified over 100 genes 19 plant species reconstructed their phylogenies, presenting potential framework evolution plants....
Abstract Stevia ( rebaudiana Bertoni) is well known for its very sweet steviol glycosides (SGs) consisting of a common tetracyclic diterpenoid backbone and variable glycone. Steviol are 150–300 times sweeter than sucrose used as natural zero-calorie sweeteners. However, the most promising compounds biosynthesized in small amounts. Based on Illumina, PacBio, Hi-C sequencing, we constructed chromosome-level assembly covering 1416 Mb with contig N50 value 616.85 kb scaffold 106.55 Mb. More...
Mitogen-activated protein kinase (MAPK) cascades play a crucial role in plant growth and development as well biotic abiotic stress responses. Knowledge about the MAPK gene family cotton is limited, systematic investigation of proteins has not been reported. By performing bioinformatics homology search, we identified 28 putative genes Gossypium raimondii genome. These members were anchored onto 11 chromosomes G. raimondii, with uneven distribution. Phylogenetic analysis showed that candidates...
Verticillium dahliae, a destructive and soil-borne fungal pathogen, causes massive losses in cotton yields. However, the resistance mechanism to V. dahilae is still poorly understood. Accumulating evidence indicates that chitinases are crucial hydrolytic enzymes, which attack pathogens by catalyzing cell wall degradation. As large gene family, date, chitinase genes (Chis) have not been systematically analyzed effectively utilized cotton. Here, we identified 47, 49, 92, 116 Chis from four...
Abstract Background Both Gossypium hirsutum and G. barbadense probably originated from a common ancestor, but they have very different agronomic fiber quality characters. Here we selected 17 development-related genes to study their structures, tree topologies, chromosomal location expression patterns better understand the interspecific divergence of development in two cultivated tetraploid species. Results The sequence structure 70.59% were conserved with same exon length numbers species,...
Mitogen-activated protein kinase (MAPK) cascades play a crucial role in plant growth and development, as well their biotic abiotic stress responses. As nodal point of the MAPK cascade, MKK gene family has not been systematically studied cotton. Here, we identified 11 putative genes Gossypium raimondii genome. Phylogenetic analysis showed that MKKs were supported by architectures conserved motifs. Expression patterns under hormone treatments or stresses revealed diverse functions Based on...
We aimed to assess the regulatory role of circular RNA (circRNA)-9119 (circ9119) in ovarian cancer (OC) cell viability. The expression circ9119 was clearly reduced OC tissues and lines, whereas microRNA-21-5p (miR-21) levels were elevated compared with those normal healthy control immortalized fallopian epithelial line FTE187. Further, overexpressed, causing a notable decrease viability proliferation cells an increase apoptosis. Further study showed that upregulation resulted miR-21 levels....
Canine parvovirus 2 (CPV-2) was first identified in 1978, and is responsible for classic parvoviral enteritis. Despite the widespread vaccination of domestic carnivores, CPVs have remained important pathogens wild carnivores. In this study, we isolated CPV-2 from Tibetan mastiffs performed a global analysis complete VP2 gene sequences strains China. Six isolates were typed as new CPV-2a, according to key amino acid positions. On phylogenetic tree, these six formed distinct clade. Five...
Esophageal cancer-related gene 4 (ECRG4) is a novel candidate tumor suppressor gene. Our study investigated the expression and function of ECRG4 in gastric cancer highlighted role DNA hypermethylation at promoter silencing expression.The GSE63089 data set was obtained from Gene Expression Omnibus analyzed for differentially expressed genes. Carcinoma para-carcinoma tissues 102 patients with were collected January 2010 to July 2011. Immunohistochemistry, real-time polymerase chain reaction...
Abstract The β-1,3-glucanase gene family is involved in a wide range of plant developmental processes as well pathogen defense mechanisms. Comprehensive analyses genes ( GLUs ) have not been reported cotton. Here, we identified 67, 68, 130 and 158 four sequenced cotton species, G. raimondii (D 5 ), arboreum (A 2 hirsutum acc. TM-1 (AD 1 barbadense 3–79 respectively. Cotton can be classified into the eight subfamilies (A–H) their protein domain architecture intron/exon structure are...
Although teleost fish developed acquired immunity firstly in evolution, innate is still very important for them. Innate depends on pattern recognition receptors (PRRs) to distinguish "self" and "non-self", Peptidoglycan (PGN) protein (PGRP) one of the it can bind multiple components bacterial envelope.We report cloning expression analysis two PGRPs (Ccpgrp5 Ccpgrp6) from common carp (Cyprinus carpio L). The Ccpgrp5 gene encodes a 199 amino acid (aa) with PGRP domain, Ami_2 domain four Zn2+...
LncRNA MIR4435-2HG is characterized as an oncogene in lung cancer. However, its role ovarian carcinoma (OC) unclear. In this study, we aimed to investigate the of OC. We found that both and transforming growth factor beta 1 (TGF-β1) were upregulated associated with tumor metastasis but not size. Upregulation distinguished early stage (Stage I II) OC patients from healthy controls. Correlation analysis showed plasma levels TGF-β1 positively correlated only patients. qPCR western blot results...
Recent studies have displayed that circular RNA plays a key regulatory role in tumorigenesis and development. However, evidence supporting the critical of prognosis colorectal cancer (CRC) is still limited. This study was designed to screen identify novel biomarkers CRC. The microarray analysis expression profile performed three matched CRC normal tissues. Compared with mucosa, total 208 differentially expressed RNAs were found CRC, which 95 upregulated 113 downregulated. Then, top 10 most...