A5100319017- Metabolism, Diabetes, and Cancer
- Diabetes Treatment and Management
- Pancreatic function and diabetes
- Adipose Tissue and Metabolism
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Adipokines, Inflammation, and Metabolic Diseases
- Mitochondrial Function and Pathology
- Diet and metabolism studies
- Pregnancy and preeclampsia studies
- Diabetes Management and Research
- Natural Antidiabetic Agents Studies
- Diet, Metabolism, and Disease
- Erythrocyte Function and Pathophysiology
- Neuroscience and Neuropharmacology Research
- Liver Disease Diagnosis and Treatment
- Thyroid Cancer Diagnosis and Treatment
- Birth, Development, and Health
- Memory and Neural Mechanisms
- TGF-β signaling in diseases
- DNA Repair Mechanisms
- Biochemical Analysis and Sensing Techniques
- Growth Hormone and Insulin-like Growth Factors
- Blood properties and coagulation
- CRISPR and Genetic Engineering
- Cardiovascular Disease and Adiposity
Chinese Academy of Agricultural Sciences
2019-2024
University of California, San Francisco
2016-2024
Capital Medical University
2023-2024
Beijing Tian Tan Hospital
2023-2024
Sun Yat-sen University
2024
The First Affiliated Hospital, Sun Yat-sen University
2024
The University of Sydney
2022-2024
Soochow University
2024
Second Affiliated Hospital of Soochow University
2024
St. Jude Children's Research Hospital
2024
Rapid screening of infected individuals from a large population is an effective means in epidemiology, especially to contain outbreaks such as COVID-19. The gold standard assays for COVID-19 diagnostics are mainly based on the reverse transcription polymerase chain reaction, which mismatches requirements wide-population due time-consuming nucleic acid extraction and amplification procedures. Here, we report direct assay by using graphene field-effect transistor (g-FET) with Y-shaped DNA dual...
In diabetes mellitus, the excessive rate of glucose production from liver is considered a primary contributor for development hyperglycemia, in particular, fasting hyperglycemia. this study, we investigated whether kaempferol, flavonol present several medicinal herbs and foods, can be used to ameliorate an animal model insulin deficiency further explored mechanism underlying anti-diabetic effect flavonol. We demonstrate that oral administration kaempferol (50 mg/kg/day)...
Tanshinones and phenolic acids are crucial bioactive compounds biosynthesized in Salvia miltiorrhiza. Methyl jasmonate (MeJA) is an effective elicitor to enhance the production of tanshinones simultaneously, while yeast extract (YE) used as a biotic that only induce accumulation. However, little was known about different molecular mechanism. To identify downstream regulatory genes involved tanshinone acid biosynthesis, we conducted comprehensive transcriptome profiling S. miltiorrhiza hairy...
Abstract MYB transcription factors play vital roles in plant growth and metabolism. The phytohormone methyl jasmonate (MeJA) promotes phenolic acid accumulation the medicinal herb Salvia miltiorrhiza , but regulatory mechanism is poorly understood. Here, we identified MeJA‐responsive R2R3‐MYB factor gene SmMYB2 from a transcriptome library produced MeJA‐treated S. hairy roots. expression was tightly correlated with of key salvianolic biosynthetic genes including CYP98A14 . highly expressed...
Long non-coding RNAs (lncRNAs) are emerging as versatile regulators in diverse biological processes. However, little is known about their cis- and trans-regulatory contributions gene expression under salt stress. Using 27 RNA-seq data sets from Populus trichocarpa leaves, stems roots, we identified 2988 high-confidence lncRNAs, including 1183 salt-induced differentially expressed lncRNAs. Among them, 301 lncRNAs have potential for positively affecting neighboring genes, predominantly a...
Brain and muscle arnt-like protein 1 (Bmal1) is a crucial transcription factor, regulating circadian rhythm involved in multiple heart diseases. However, it unknown whether Bmal1 promotes diabetic cardiomyopathy (DCM) pathogenesis. The objective of this investigation was to ascertain the vital role progression DCM. Mice with T2D H9c2 cardiomyoblasts exposed high glucose palmitic acid (HGHP) were used. Cardiomyocyte-specific knockout mouse (CKB) also generated, cardiac overexpressed type 2...
Studies suggest a correlation between excessive sedentary behavior, insufficient physical activity, and an elevated likelihood of experiencing psychiatric disorder. Nonetheless, the precise influence behavior activity on disorder remains uncertain. Hence, objective this research was to investigate possible causal relationship susceptibility (depression, schizophrenia bipolar disorder), utilizing two-sample Mendelian randomization (MR) approach.
BackgroundThe failure of immune surveillance to remove senescent cells drives age-related diseases. Here, we target an endogenous mechanism that can promote elimination and reverse disease progression.MethodsWe identify a class lipid-activated T cells,invariant natural killer (iNKTs), are involved in the removal pathologic cells. We use two models which accumulate test whether activation iNKT was sufficient eliminate vivo.FindingsSenescent preadipocytes white adipose tissue chronic high-fat...
The molecular transducers conferring the benefits of chronic exercise in diabetes prevention remain to be comprehensively investigated. Herein, serum proteomic profiling 688 inflammatory and metabolic biomarkers 36 medication-naive overweight obese men with prediabetes reveals hundreds exercise-responsive proteins modulated by 12-week high-intensity interval training, including regulators metabolism, cardiovascular system, inflammation, apoptosis. Strong associations are found between...
Dehydroepiandrosterone (DHEA) activates a plasma membrane receptor on vascular endothelial cells and phosphorylates ERK 1/2. We hypothesize that ERK1/2-dependent proliferation underlies part of the beneficial effect DHEA. DHEA (0.1–10 nm) activated ERK1/2 in bovine aortic (BAECs) by 15 min, causing nuclear translocation phosphorylated phosphorylation p90 ribosomal S6 kinase. was dependent membrane-initiated activation Gi/o proteins upstream MAPK kinase because seen with albumin-conjugated...
Berberine, one of the major constituents Chinese herb Rhizoma coptidis, has been demonstrated to lower blood glucose, lipid, and body weight in patients with type 2 diabetes mellitus. The anti-obesity effect berberine attributed its anti-adipogenic activity. However, underlying molecular mechanism remains largely unknown. In present study, we found that significantly suppressed expressions CCAAT/enhancer-binding protein (C/EBP)α, peroxisome proliferators-activated receptor γ2 (PPARγ2), other...
Abstract Objective: To investigate the role of transforming growth factor‐β1 (TGF‐β1)/Smad3 signaling pathway in development ovarian follicle by promoting apoptosis granulosa cells polycystic ovary syndrome (PCOS). Methods A total 54 female rats were obtained and randomly assigned into PCOS ( n = 27) control groups 27). rat models constructed using dehydroepi‐androsterone method to observe morphology ultrastructure. Chemiluminescence immunoassay was performed detect levels luteinizing...
Abstract Recent studies showed that GPR30, a seven-transmembrane G-protein-coupled receptor, is novel estrogen receptor (ER) mediates some biological events elicited by in several types of cancer cells. However, its physiological or pathological role vivo unclear. Here, we show GPR30 knockout (GPRKO) female mice were protected from high-fat diet (HFD)-induced obesity, blood glucose intolerance and insulin resistance. The decreased body weight gain GPRKO due to the reduction fat mass. These...
Ovarian cancer is the deadliest gynecological in women, with a survival rate of less than 30% when has spread throughout peritoneal cavity. Aggregation cells increases their viability and metastatic potential; however, there are limited studies that correlate these functional changes to specific phenotypic alterations. In this study, we investigated mitochondrial morphology dynamics during malignant transition using our MOSE cell model for progressive serous ovarian cancer. Mitochondrial was...