A5034887388- Advanced biosensing and bioanalysis techniques
- Biosensors and Analytical Detection
- SARS-CoV-2 detection and testing
- Conducting polymers and applications
- Perovskite Materials and Applications
- TiO2 Photocatalysis and Solar Cells
- Organic Electronics and Photovoltaics
- Advanced Photocatalysis Techniques
- Extracellular vesicles in disease
- Advanced Nanomaterials in Catalysis
- Neuroscience and Neural Engineering
- Analytical Chemistry and Sensors
- RNA and protein synthesis mechanisms
- Nanopore and Nanochannel Transport Studies
- Crystallization and Solubility Studies
- Viral Infections and Immunology Research
- 2D Materials and Applications
- Ferroelectric and Negative Capacitance Devices
- Covalent Organic Framework Applications
- Tactile and Sensory Interactions
- Advanced Memory and Neural Computing
- Advanced Sensor and Energy Harvesting Materials
- Graphene research and applications
- Gene expression and cancer classification
- Nanowire Synthesis and Applications
Fudan University
2021-2025
Shenzhen Institutes of Advanced Technology
2025
Chinese Academy of Sciences
2025
Shenzhen Institute of Information Technology
2025
Tianjin University of Technology
2016-2019
Rapid screening of infected individuals from a large population is an effective means in epidemiology, especially to contain outbreaks such as COVID-19. The gold standard assays for COVID-19 diagnostics are mainly based on the reverse transcription polymerase chain reaction, which mismatches requirements wide-population due time-consuming nucleic acid extraction and amplification procedures. Here, we report direct assay by using graphene field-effect transistor (g-FET) with Y-shaped DNA dual...
Dithieno[3,2-<italic>b</italic>:2′,3′-<italic>d</italic>]pyrrole (DTP) derivatives are one of the most important organic photovoltaic materials due to better π-conjugation across fused thiophene rings.
The core plays a crucial role in achieving high performance of linear hole transport materials (HTMs) toward the perovskite solar cells (PSCs). Most studies focused on development fused heterocycles as cores for HTMs. Nevertheless, nonfused deserve to be studied since they can easily synthesized. In this work, we reported series low-cost triphenylamine HTMs (M101-M106) with different cores. Results concluded that introduced has significant influence conductivity, mobility, energy level, and...
Effective screening of infectious diseases requires a fast, cheap, and population-scale testing. Antigen pool testing can increase the test rate shorten time, thus being valuable approach for epidemic prevention control. However, overall percent agreement (OPA) with polymerase chain reaction (PCR) is one-half to three-quarters, hampering it from comprehensive method, especially testing, beyond gold-standard PCR. Here, multiantibodies transistor assay developed sensitive highly precise...
The existing electrochemical biosensors lack controllable and intelligent merit to modulate the sensing process upon external stimulus, leading challenges in analyzing a few copies of biomarkers unamplified samples. Here, we present self-actuated molecular-electrochemical system that consists tentacle trunk modification on graphene microelectrode. contains probe an label keeps upright orientation, which increases recognition efficiency while decreasing pseudosignal. Once nucleic acids are...
Accurate and population-scale screening technology is crucial in the control prevention of COVID-19, such as pooled testing with high overall efficiency. Nevertheless, faces challenges sensitivity specificity due to diluted targets increased contaminations. Here, we develop a graphene field-effect transistor sensor modified triple-probe tetrahedral DNA framework (TDF) dimers for 10-in-1 SARS-CoV-2 RNA. The synergy effect triple probes well special nanostructure achieve higher binding...
Abstract “Test‐and‐go” single‐nucleotide variation (SNV) detection within several minutes remains challenging, especially in low‐abundance samples, since existing methods face a trade‐off between sensitivity and testing speed. Sensitive usually relies on complex time‐consuming nucleic acid amplification or sequencing. Here, graphene field‐effect transistor (GFET) platform mediated by Argonaute protein that enables rapid, sensitive, specific SNV is developed. The provides nanoscale binding...
MicroRNAs (miRNAs) have emerged as powerful biomarkers for disease diagnosis and screening. Traditional miRNA analytical techniques are inadequate point-of-care testing due to their reliance on specialized expertise instruments. Graphene field-effect transistors (GFETs) offer the prospect of simple label-free diagnostics. Herein, a GFET biosensor based tetrahedral DNA nanostructure (TDN)-assisted catalytic hairpin assembly (CHA) reaction (TCHA) has been fabricated applied sensitive specific...
The CRISPR/Cas system is a powerful genome editing tool and possesses widespread applications in molecular diagnostics, therapeutics genetic engineering. But easy folding of the target sequences causes remarkable deterioration recognition shear efficiency case single Cas-CRISPR RNA (crRNA) duplex. Here, we develop cooperative shearing (CRISPR-CS) system. Compared with traditional system, two CRISPR/Cas-crRNA duplexes simultaneously recognize different sites sequence, increasing possibility...
Abstract For epidemic prevention and control, molecular diagnostic techniques such as field‐effect transistor (FET) biosensors is developed for rapid screening of infectious agents, including Mycobacterium tuberculosis , SARS‐CoV‐2, rhinovirus, others. They obtain results within a few minutes but exhibit diminished sensitivity (<75%) in unprocessed biological samples due to insufficient recognition low‐abundance analytes. Here, an electro‐enhanced strategy the precise detection...
Fused-ring thiophene compounds emerged as an important type of building blocks for organic dyes toward the dye-sensitized solar cells (DSSCs) because their good charge transfer and light-harvesting properties. Nevertheless, some fused-ring thiophenes have a lack desired alkyl chains or side chains, which may induce severe recombination in devices. In this work, hex-1-en-1-ylbenzene (HEYB) unit was introduced two new (M60 M59), resulting modest dihedral angle (∼36°) between donor spacer dyes....
An aptamer-based field-effect transistor (Apta-FET) is a well-developed assay method with high selectivity and sensitivity. Due to the limited information density that natural nucleotide library holds, Apta-FET faces fundamental restriction in universality detect various types of analytes. Herein, we demonstrate type sensors based on an artificial aptamer (AN-Apta-FET). The introduction increases diversity potential structure expands analyte category Apta-FET. AN-Apta-FET specifically...
In biological neural networks, chemical communication follows the reversible integrate-and-fire (I&F) dynamics model, enabling efficient, anti-interference signal transport. However, existing artificial neurons fail to follow I&F model in communication, causing irreversible potential accumulation and system dysfunction. Herein, we develop a supercapacitively gated neuron that mimics model. Upon upstream neurotransmitters, an electrochemical reaction occurs on graphene nanowall (GNW) gate...
It is significant to search for ultrasensitive and accurate testing technology point-of-care monitoring of common diseases at home; example, the Aβ-42 level any time crucial patients suffering from Alzheimer’s disease. However, accurately in serum often thwarted by challenges sensitivity specificity due multiplicated contaminations intricated biofluid environments. Here, we develop a graphene field-effect transistor (G-FET) sensor modified with type rigid DNA framework aptamer—tetrahedral...
To achieve high-precision intelligent tactile recognition and hyperfine operation tasks, sensors need to possess the ability discriminate minute pressures within range of human perception. However, due lack methodologies for noise suppression, existing sensing mechanisms are inferior in pressure resolution. In this work, we emulate structure biological fingertip Merkel cells develop a quasi-2D vertical tunneling sensor based on conformal graphene nanowalls-hexagonal boron nitride-graphene...
Thieno[3,2-<italic>b</italic>]indole-based hole transporting materials were developed for efficient perovskite solar cells.
An antibody transistor is a promising biosensing platform for the diagnosis and monitoring of various diseases. Nevertheless, low concentration short half-life biomarkers require biodetection at trace-molecule level, which remains challenge existing transistors. Herein, we demonstrate graphene field-effect (gFET) with electrically oriented probes (EOA-gFET) several copies methylated DNA. The electric field confines orientation on diminishes distance between DNAs captured by antibodies,...
Abstract Photo‐transduction of solid‐state optoelectronics occurs in semiconductors or their interfaces. Considering the confined active area and interfacial capacitance materials, faces inherent limitations photo‐transduction, especially for bionic vision, performance is lower than that living systems. For example, a photoreceptor generates pA‐level photocurrent when absorbing single photon. Here, liquid‐solid dual‐state phototransistor demonstrated, which photo‐transduction modulation take...
Deeply understanding of the performance discrepancy hole-transporting materials (HTMs) in perovskite solar cells (PSCs) with different configuration (inverted or direct) is important for designing efficient HTMs. Herein, three organic HTMs TZ1, TZ2, and TZ3 have been employed to fabricate inverted PSCs. Optoelectronic properties photovoltaic these are investigated. featuring 3,6-di(thiophen2-yl)thieno[3,2-b]thiophene conjugate bridge shows a higher work function enhanced capability hole...
The DNA nanostructure conformation changes with an increase in UVC dose while graphene field-effect transistors convert the response to electrical signals, resulting sensitive and direct detection.
Abstract The CRISPR/Cas system is a powerful genome editing tool and possesses widespread applications in molecular diagnostics, therapeutics genetic engineering. But easy folding of the target sequences causes remarkable deterioration recognition shear efficiency case single Cas‐CRISPR RNA (crRNA) duplex. Here, we develop cooperative shearing (CRISPR‐CS) system. Compared with traditional system, two CRISPR/Cas‐crRNA duplexes simultaneously recognize different sites sequence, increasing...
Self-assembly of sensitizers at TiO<sub>2</sub> surfaces is crucial to reduce charge loss in cobalt complex-based DSSCs.