A5061953839- Atherosclerosis and Cardiovascular Diseases
- Single-cell and spatial transcriptomics
- Cell Image Analysis Techniques
- AI in cancer detection
- Immune cells in cancer
- Cardiac Imaging and Diagnostics
- Hepatocellular Carcinoma Treatment and Prognosis
- Mitochondrial Function and Pathology
- Cardiovascular Function and Risk Factors
- Cardiomyopathy and Myosin Studies
- Clusterin in disease pathology
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Cancer, Hypoxia, and Metabolism
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Nuclear Receptors and Signaling
- Digital Imaging for Blood Diseases
- Eosinophilic Disorders and Syndromes
- Cardiovascular Effects of Exercise
- Ginseng Biological Effects and Applications
- Neurofibromatosis and Schwannoma Cases
- Advanced Proteomics Techniques and Applications
- Mechanisms of cancer metastasis
- Glioma Diagnosis and Treatment
- Advanced Graph Neural Networks
- Topic Modeling
Nanchang University
2023-2025
Second Affiliated Hospital of Nanchang University
2023-2024
University of Virginia
2019-2023
University Medical Center
2023
Beijing University of Posts and Telecommunications
2021
The atherosclerotic plaque microenvironment is highly complex, and selective agents that modulate stability are not yet available. We sought to develop a scRNA-seq analysis workflow investigate this environment uncover potential therapeutic approaches. designed user-friendly, reproducible will be applicable other disease-specific datasets.Here we incorporated automated cell labeling, pseudotemporal ordering, ligand-receptor evaluation, drug-gene interaction into ready-to-deploy workflow....
Ovarian cancer is the deadliest gynecological in women, with a survival rate of less than 30% when has spread throughout peritoneal cavity. Aggregation cells increases their viability and metastatic potential; however, there are limited studies that correlate these functional changes to specific phenotypic alterations. In this study, we investigated mitochondrial morphology dynamics during malignant transition using our MOSE cell model for progressive serous ovarian cancer. Mitochondrial was...
Portal vein tumor thrombosis (PVTT) signifies late-stage hepatocellular carcinoma (HCC) with high-risk progression and poor prognosis. As a standard treatment, sorafenib monotherapy has limited the efficacy in managing HCC PVTT. Currently, both hepatic arterial infusion chemotherapy (HAIC) combination of camrelizumab rivoceranib have shown favorable survival benefits for advanced HCC, surpassing treatment. In this study, we investigate safety HAIC combined treating patients
It is difficult to determine a cause of bile duct stricture and dilatation. Eosinophilic cholangitis, rare benign condition, may be one can evaluated using various methods histopathology, radiographs, endoscopy, hematologic findings. Treatment generally involves steroid therapy which lead improvement. This case report will discuss eosinophilic emphasizing that while it easily overlooked but should considered in differential diagnoses.
Intraplaque haemorrhage (IPH) represents a critical feature of plaque vulnerability as it is robustly associated with adverse cardiovascular events, including stroke and myocardial infarction. How IPH drives instability unknown. However, its identification quantification in atherosclerotic plaques currently performed manually, high inter-observer variability, limiting accurate assessment large cohorts. Leveraging the Athero-Express biobank, an ongoing study comprising comprehensive dataset...
Abstract Tissue segmentation of histology whole-slide images (WSI) remains a critical task in automated digital pathology workflows for both accurate disease diagnosis and deep phenotyping research purposes. This is especially challenging when the tissue structure biospecimens relatively porous heterogeneous, such as atherosclerotic plaques. In this study, we developed unique approach called ‘EntropyMasker’ based on image entropy to tackle fore- background (masking) WSI. We evaluated our...
Single-cell RNA-seq (scRNA-seq) is a powerful genomics technology to interrogate the cellular composition and behaviors of complex systems. While number scRNA-seq datasets available computational analysis tools have grown exponentially, there are limited systematic data sharing strategies allow rapid exploration re-analysis single-cell datasets, particularly in cardiovascular field. We previously introduced PlaqView, an open-source web portal for published atherosclerosis datasets. Now, we...
Abstract Background and Aims The atherosclerotic plaque microenvironment is highly complex, selective agents that modulate stability or other phenotypes are not yet available. We sought to investigate the human cellular environment using scRNA-seq uncover potential therapeutic approaches. aimed make our workflow user-friendly, reproducible, applicable disease-specific datasets. Methods Here we incorporate automated cell labeling, pseudotemporal ordering, ligand-receptor evaluation, drug-gene...
Abstract Background and aims The accumulation of erythrocyte membranes within an atherosclerotic plaque may contribute to the deposition free cholesterol thereby enlargement necrotic core. Erythrocyte can be visualized quantified in by immunostaining for marker glycophorin C. Consequently, we hypothesized, that erythrocytes C is a vulnerability therefore reflect intraplaque hemorrhage (IPH), plaques predict pre-procedural neurological symptoms. Methods We employed CellProfiler -integrated...
The aim of this study is to assess the effectiveness conventional and two additional functional markers derived from standard cardiac magnetic resonance (CMR) images in detecting occurrence late gadolinium enhancement (LGE) patients with secondary amyloidosis (CA) related multiple myeloma (MM). This retrospectively included 32 preserved ejection fraction (EF) who had MM-CA diagnosed consecutively. Conventional left ventricular (LV) function markers, namely myocardial contraction (MCF) LV...
The purpose of this study was to evaluate the function left ventricular (LV) in multiple myeloma (MM) with secondary cardiac amyloidosis (MM-CA) patients by magnetic resonance feature tracking (CMR-FT), and investigate role simple fast CMR-FT long-axis strain (LAS) analysis predicting late gadolinium enhancement (LGE). results showed LV more impaired enhanced (LGE+) than no-enhanced (LGE-) MM-CA patients. Among investigated parameters, LAS presented best prediction efficacy LGE. Our...
Radiology plays a highly crucial role in the diagnosis, treatment, and prognosis prediction of dilated cardiomyopathy (DCM). Related research has increased rapidly over past few years, but systematic analyses are lacking. This study thus aimed to provide reference for further by analyzing knowledge field, development trends, hotspots radiology DCM using bibliometric methods.Articles on published between 2002 2021 Web Science Core Collection database (WoSCCd) were searched analyzed. Data...
Hypertrophic cardiomyopathy (HCM) is a common genetic cardiac disorder characterized by the hypertrophy of segment myocardium. Cardiac magnetic resonance (CMR) has been widely used in assessment HCM. However, no bibliometric conducted on progress research this field. This study thus aimed to examine current state into application CMR HCM and hotspots trends that have emerged field over past decade.
Background: Atherosclerosis is a primary risk factor underlying myocardial infarction and stroke, there remains an unmet need to identify atherosclerotic plaque subtypes improve clinical outcomes. Histological examination used manually characterize the extent type of atherosclerosis, histological traits are associated with major adverse cardiovascular events (MACE). Recent applications automated machine learning approaches may scalability precision in predicting symptoms events, however this...
Abstract The accumulation of erythrocyte membranes within an atherosclerotic plaque may contribute to the deposition free cholesterol and thereby enlargement necrotic core. Erythrocyte can be visualized quantified in by immunostaining for marker glycophorin C. Hence, we theorized that erythrocytes C could function as a vulnerability, possibly reflecting intraplaque hemorrhage (IPH), offering predictive value pre-procedural neurological symptoms. We employed CellProfiler-integrated...
<title>Abstract</title> <bold>Background:</bold> Portal vein tumor thrombosis (PVTT) signifies late-stage hepatocellular carcinoma (HCC) with high-risk progression and poor prognosis. As a standard treatment, sorafenib monotherapy has limited efficacy in managing HCC PVTT. Currently, both hepatic arterial infusion chemotherapy (HAIC) the combination of camrelizumab rivoceranib have shown favorable survival benefits for advanced HCC, surpassing treatment. In this study, we investigate safety...
During metastasis, ovarian cancer cells exfoliate from the primary tumor and disseminate throughout peritoneal cavity mostly as aggregates with a higher survival rate metastatic potential. To determine how mitochondrial morphology dynamic expression of fusion fission-regulating proteins contribute to spheroid survival, in this study we investigated changes order identify phenotypic alterations that are associated function. We compared monolayers spheroids murine human benign, late-stage,...