A5040933927- Cardiovascular Health and Disease Prevention
- Clusterin in disease pathology
- Genetic Associations and Epidemiology
- Cancer Genomics and Diagnostics
- Cardiovascular Disease and Adiposity
- Epigenetics and DNA Methylation
- Cerebrovascular and Carotid Artery Diseases
- Birth, Development, and Health
- Cardiac Fibrosis and Remodeling
- Cancer Cells and Metastasis
- Advanced Proteomics Techniques and Applications
- Sex and Gender in Healthcare
- Congenital heart defects research
- Single-cell and spatial transcriptomics
- Cardiac Imaging and Diagnostics
- Atherosclerosis and Cardiovascular Diseases
- Cell Image Analysis Techniques
University Medical Center Utrecht
2018-2024
Utrecht University
2021-2024
Heidelberg University
2021-2024
University Hospital Heidelberg
2021-2024
Epigenetic age estimators (clocks) are predictive of human mortality risk. However, it is not yet known whether the epigenetic atherosclerotic plaques for risk cardiovascular events.
Abstract Background and aims The accumulation of erythrocyte membranes within an atherosclerotic plaque may contribute to the deposition free cholesterol thereby enlargement necrotic core. Erythrocyte can be visualized quantified in by immunostaining for marker glycophorin C. Consequently, we hypothesized, that erythrocytes C is a vulnerability therefore reflect intraplaque hemorrhage (IPH), plaques predict pre-procedural neurological symptoms. Methods We employed CellProfiler -integrated...
Abstract Background Sex and plaque histology are intertwined, with fibrous atherosclerotic plaques being more prevalent in women pointing to general smooth muscle cell plasticity estrogen signaling. Plaque erosion, a significant contributor acute coronary syndromes (ACSs), is linked as compared men. We hypothesize that the molecular drivers of histologically determined differ between men women. Methods Human end-stage were isolated from consecutive patients who underwent carotid...
Abstract The accumulation of erythrocyte membranes within an atherosclerotic plaque may contribute to the deposition free cholesterol and thereby enlargement necrotic core. Erythrocyte can be visualized quantified in by immunostaining for marker glycophorin C. Hence, we theorized that erythrocytes C could function as a vulnerability, possibly reflecting intraplaque hemorrhage (IPH), offering predictive value pre-procedural neurological symptoms. We employed CellProfiler-integrated...