A5079469538- RNA modifications and cancer
- Gastric Cancer Management and Outcomes
- Cancer-related molecular mechanisms research
- Colorectal Cancer Surgical Treatments
- MicroRNA in disease regulation
- Cancer-related gene regulation
- Colorectal Cancer Screening and Detection
- Epigenetics and DNA Methylation
- Circular RNAs in diseases
- Metastasis and carcinoma case studies
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Colorectal and Anal Carcinomas
- Colorectal Cancer Treatments and Studies
- Esophageal Cancer Research and Treatment
- Cancer Cells and Metastasis
- Viral Infectious Diseases and Gene Expression in Insects
- RNA Research and Splicing
- Insect Resistance and Genetics
- Dental Health and Care Utilization
- Helicobacter pylori-related gastroenterology studies
- Oral microbiology and periodontitis research
- Autophagy in Disease and Therapy
- Gastrointestinal Tumor Research and Treatment
- RNA and protein synthesis mechanisms
- Ubiquitin and proteasome pathways
China Medical University
2016-2025
Fourth Affiliated Hospital of China Medical University
2016-2025
Beijing Center for Disease Prevention and Control
2024
Nanjing Tech University
2024
Creative Commons
2023
The University of Tokyo
2018-2023
Chongqing Medical University
2012-2023
China National Nuclear Corporation
2023
Zhongnan Hospital of Wuhan University
2021
Wuhan University
2021
Hexokinase-2(HK-2) plays dual roles in glucose metabolism and mediation of cell apoptosis, making it an attractive target for cancer therapy. Chrysin is a natural flavone found plant extracts which are widely used as herb medicine China. In the present study, we investigated antitumor activity chrysin against hepatocellular carcinoma (HCC) role HK-2 played to exert its function.The expression HCC line tumor tissue was examined by western blotting immunohistochemistry staining. The activities...
Rationale: Colorectal cancer (CRC) is one of the most common cancers worldwide. Ciclopirox olamine (CPX) has recently been identified to be a promising anticancer candidate; however, novel activities and detailed mechanisms remain uncovered. Methods: The cytotoxic potential CPX towards CRC cells was examined in vitro vivo. global gene expression pattern, ROS levels, mitochondrial function, autophagy, apoptosis, etc. were determined between control CPX-treated cells. Results: We found that...
Deubiquitination, a post-translational modification regulated by deubiquitinases, is essential for cancer initiation and progression. Ubiquitin-specific proteases (USPs) are elements of the deubiquitinase family, overexpressed in gastric (GC). Through regulation several signaling pathways, such as Wnt/β-Catenin nuclear factor-κB signaling, promotion expression deubiquitination- stabilization-associated proteins, USPs promote proliferation, metastasis, invasion, epithelial-mesenchymal...
Abstract Metastasis remains a big barrier for the clinical treatment of colorectal cancer (CRC). Our previous proteomics analysis identified DJ-1 as potential metastasis biomarker CRC. In this study, we found that was upregulated in The levels were closely correlated with depths invasion and predicted patient outcome. Enforced expression could enhance CRC proliferation vitro vivo by stimulating Wnt-β-catenin signaling. Specifically, DJ-1-induced β-catenin nuclear translocation stimulated TCF...
Cervical cancer is one of the most common gynecological malignancies with poor prognosis due to constant chemoresistance and repeated relapse. Ciclopirox olamine (CPX), a synthetic antifungal agent, has recently been identified be promising anti-cancer candidate. However, detailed mechanisms related its effects remain unclear need further elucidated. In this study, we found that CPX could induce proliferation inhibition in cervical cells by targeting PARK7. Further results demonstrated...
Abstract The burdens and trends of gastric cancer are poorly understood, especially in high-prevalence countries. Based on the Global Burden Disease Study 2019, we analyzed incidence, death, possible risk factors five Asian countries, relation to year, age, sex, sociodemographic index. annual percentage change was calculated estimate age-standardized incidence rate (ASIR) death (ASDR). highest ASIR per 100,000 person-years 2019 Mongolia [44 (95% uncertainty interval (UI), 34 55)], while...
The incidence of early-onset colorectal cancer (CRC) diagnosed before age 50 has been increasing over the past decades. Hence, we examined global, regional, and national burden CRC its risk factors from 1990 to 2019.Using data Global Burden Disease (GBD) Study 2019, reported incidence, deaths, disability-adjusted life-years (DALYs) attributable CRC. All estimates were with 95% uncertainty intervals (UIs).The global numbers for DALYs in 2019 225,736 (95% UI, 207,658 246,756), 86,545 (80,162...
Necroptosis plays a double-edged sword role in necroptotic cancer cell death and tumor immune escape. How orchestrates necroptosis with escape progression remains largely unclear. We found that RIP3, the central activator of necroptosis, was methylated by PRMT1 methyltransferase at amino acid RIP3 R486 human conserved R479 mouse. The methylation inhibited interaction RIP1 to suppress RIP1-RIP3 necrosome complex, thereby blocking phosphorylation activation. Moreover, methylation-deficiency...
Nidogen-1 (NID1) has been identified as a novel candidate diagnostic biomarker of ovarian cancer in our previous study. Nevertheless, the role NID1 pathogenesis is unclear. In present study, we demonstrated that was mesenchymal associated gene and its high expression significantly correlated with shorter overall survival patients. The ectopic OVCAR-3 cells revealed epithelial-mesenchymal transition (EMT) phenotype accompanied by enhancement motility, invasiveness cisplatin resistance,...
Abstract Betulinic acid (BA) exhibits cytotoxic activity against some cancer cells. However, the molecular mechanism of BA CRC cells was little reported. Here, we proved that elicited cells' growth inhibition and apoptosis in a dose-dependent manner. In addition, treatment induced autophagy via inhibiting AKT-MTOR signaling pathway. Inhibition by either administration autophagic inhibitor chloroquine or siRNA-mediated knockdown ATG5 could augment BA-induced apoptotic cell death as well...
MicroRNAs deregulation are common in human tumor progression. miR-1236-3p has been reported to function as suppressor microRNA various malignancies. The aim of this study was demonstrate the downregulated expression gastric cancer (GC) tissues and cell lines, clarify its biological GC.Real-time polymerase chain reaction used measure mRNA level GC. Dual luciferase assay that MTA2 one candidate target genes miR-1236-3p. Western blots were utilized detect protein levels. Cell assays also...
Background Hypoxia is one driving factor of gastric cancer. It causes a series immunosuppressive processes and malignant cell responses, leading to poor prognosis. clinically important identify the molecular markers related hypoxia. Methods We screened prognostic hypoxia in The Cancer Genome Atlas database, risk score model was developed based on these markers. relationships between tumor immune microenvironment were investigated. An independent validation cohort from Gene Expression Omnibus...
DEPDC1 is a recently identified novel tumor-related gene that upregulated in several types of cancer and contributes to tumorigenesis. In this study, we have investigated the expression pattern functional implications during cell cycle progression. Expression studies using synchronized cells demonstrated highly expressed mitotic phase cycle. Immunofluorescence assays showed predominantly localized nucleus interphase redistributed into whole upon nuclear membrane breakdown metaphase....