A5079188967- Neuroscience and Neuropharmacology Research
- Epilepsy research and treatment
- Parkinson's Disease Mechanisms and Treatments
- Advanced MRI Techniques and Applications
- Amino Acid Enzymes and Metabolism
- Advanced Neuroimaging Techniques and Applications
- Systemic Lupus Erythematosus Research
- RNA regulation and disease
- RNA and protein synthesis mechanisms
- Multiple Sclerosis Research Studies
- Medical Imaging Techniques and Applications
- Pleural and Pulmonary Diseases
- Lung Cancer Diagnosis and Treatment
- Neurological disorders and treatments
- Asthma and respiratory diseases
- Electrochemical Analysis and Applications
- IL-33, ST2, and ILC Pathways
- Molecular Sensors and Ion Detection
- Electrochemical sensors and biosensors
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Lanthanide and Transition Metal Complexes
- Tracheal and airway disorders
Shantou University
2021-2024
Second Affiliated Hospital of Shantou University Medical College
2022-2024
The Second Affiliated Hospital of Xiamen Medical College
2023
Shantou University Medical College
2021
Video-assisted thoracic surgery (VATS) is a minimally invasive technique for the diagnosis and management of small pulmonary nodular lesions However, identification some lung nodules remains difficult.This research aimed to investigate clinical value preoperative computed tomography (CT)-guided hookwire localization solitary (SPNs) thoracoscopic resection.Seventy-one patients with 74 SPNs underwent VATS wedge resection after CT-guided localization. The mean diameter was 8.50 ± 4.53...
Purpose: This study aimed to detect changes in iron deposition and neural microstructure the substantia nigra (SN), red nucleus (RN), basal ganglia of Parkinson's disease (PD) patients at different stages using quantitative susceptibility mapping diffusion kurtosis imaging identify potential indicators early-stage PD. Methods: We enrolled 20 15 late-stage PD patients, as well age- sex-matched controls. All participants underwent determine magnetic (MS), fractional anisotropy (FA), mean...
Neurotransmitter deficits and spatial associations among neurotransmitter distribution, brain activity, clinical features in Parkinson's disease (PD) remain unclear. Better understanding of impairments PD may provide potential therapeutic targets. Therefore, we aimed to investigate the relationship between PD-related patterns deficits.
Positron emission tomography (PET) probes are specific and sensitive while suffering from radiation risk. It is worthwhile to explore the chemical saturation transfer (CEST) effects of probe prototypes repurpose them for CEST imaging avoid radiation. In this study, we used 11C-PiB as an example a PET detecting amyloid tested feasibility repurposing prototype, PiB, imaging. After optimizing parameters through preliminary phantom experiments, APP/PS1 transgenic mice age-matched C57 in vivo...
Introduction Despite verifying proton magnetic resonance spectroscopy ( 1 H-MRS) for focal localization in imaging (MRI)-negative temporal lobe epilepsy (TLE), it is necessary to illustrate metabolic changes and screen effective biomarkers monitoring therapeutic effect. We used H-MRS investigate the role of levels MRI-negative TLE. Materials methods Thirty-seven patients n = 37, 14 women) 20 healthy controls 20, 11 were investigated by H-MRS. compared metabolite level epileptic contralateral...
Current diagnosis of MRI-negative TLE relies on clinical history and EEG or IEEG. However, IEEG is invasive fails to monitor therapeutic effects dynamically. It necessary screen for effective biomarkers. We used MEGA-PRESS technique investigate role GABA other metabolic alterations in TLE. demonstrated that GABA, NAA, NAA+NAAG, Glu levels MTL were significantly different between epileptic contralateral sides, increasing index values associated with seizure frequency. These findings suggested...
Caffeine is the most widely consumed psychostimulant. Despite this, effects of acute caffeine intake on brain metabolite levels remain largely unknown. We aimed to investigate effect concentrations in different consumption habit groups and explore association between changes sleepiness.Forty-five healthy adults were divided into based their daily consumption: ≥1 cup/day, <1 no consumption. The exclusion criteria presence neurological disorder, habitual mind-altering substances, individuals...
This study proposed to detect changes in brain microstructure patients with Parkinson’s disease (PD) using diffusion kurtosis imaging (DKI) quantitatively diagnose early-stage PD. Conventional magnetic resonance and DKI scanning were performed 24 PD 12 age- sex-matched healthy participants. Hoehn Yahr (H–Y) stage Unified Disease Rating Scale-III (UPDRS-III) scores obtained from both groups. The mean (MK), axial kurtosis, radial of the bilateral substantia nigra on measured compared between...