A5017973685- Advanced MRI Techniques and Applications
- Neuroscience and Neuropharmacology Research
- MRI in cancer diagnosis
- Lanthanide and Transition Metal Complexes
- Advanced Neuroimaging Techniques and Applications
- Radiomics and Machine Learning in Medical Imaging
- Neurogenesis and neuroplasticity mechanisms
- Tryptophan and brain disorders
- Electron Spin Resonance Studies
- Epilepsy research and treatment
- Mitochondrial Function and Pathology
- Stress Responses and Cortisol
- Amino Acid Enzymes and Metabolism
- Metabolomics and Mass Spectrometry Studies
- Gastric Cancer Management and Outcomes
- Breast Lesions and Carcinomas
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Sleep and Wakefulness Research
- Sleep and related disorders
- NMR spectroscopy and applications
- Magnetism in coordination complexes
- Medical Imaging Techniques and Applications
- Acute Ischemic Stroke Management
- Diet and metabolism studies
- Circadian rhythm and melatonin
The Second Affiliated Hospital of Xiamen Medical College
2019-2024
Xiamen Medical College
2019-2024
Jiangnan University
2015-2024
Lung Institute
2024
Cedars-Sinai Medical Center
2024
Sichuan University
2012-2023
West China Hospital of Sichuan University
2023
Guangdong Academy of Sciences
2021
Second Affiliated Hospital of Shantou University Medical College
2013-2020
Shantou University
2013-2020
Magnetic Resonance Spectroscopy (MRS) is a noninvasive tool to reveal metabolic information. One challenge of <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">1</sup> H-MRS the low Signal-Noise Ratio (SNR). To improve SNR, typical approach perform large number Signal Averaging (SA). The data acquisition time, however, proportional SA accordingly. A complete clinical MRS scan takes approximately 10 minutes in common setting with 128. Recently,...
Asthma is a prevalent respiratory disorder with limited treatment strategy. Neuropeptide S (NPS) highly conserved peptide via binding to its receptor NPSR, susceptibility gene for asthma from genomics studies. However, little known about the role of NPS-NPSR in pathogenesis asthma. This study was performed determine effect and underlying mechanism on NPSR knockdown verified affect through autophagy by transcriptome sequencing molecular biology experiments animal models. Silencing...
Abstract Adolescent exposure to social stress precipitates emotion-related disorders and affects the development function of medial prefrontal cortex (mPFC). However, this adversity-induced behavioral neurological changes remain not fully explored. Balb/c mice were subjected intermittent defeat during postnatal days 28 42. Proton magnetic resonance spectroscopy ( 1 H-MRS) measurements, tests immunohistochemistry performed one day or 3 weeks after last episode. Defeated exhibited hypoactivity...
Abstract Sleep disturbance is common in patients with Alzheimer’s disease (AD), and orexin A a pivotal neurotransmitter for bidirectionally regulating the amyloid-β (Aβ) deposition of AD brain poor sleep. In present study, we examined characteristic sleep–wake architecture APPswe/PSldE9 (APP/PS1) Aβ-treated mice using electroencephalogram (EEG) electromyographic (EMG) analysis. We compared expression A, distribution, morphology corresponding A-positive neurons innovative methods including...
Idiopathic pulmonary fibrosis (IPF) is a progressive fatal lung disease with limited therapeutic strategy. Mitochondrial oxidative stress in macrophages directly linked to IPF. Elamipretide(SS-31) mitochondrion-targeted peptide that has been shown be safe and beneficial for multiple diseases. However, whether SS-31 alleviates IPF unclear. In the present study, we used bleomycin (BLM)-induced mouse model followed by injection every other day investigate its role explore possible mechanism....
Despite improvements in imaging techniques, it remains challenging to quantitatively assess the time of ischemic onset an acute stroke. It is crucial evaluate early signs infarction, which are predictive responses recombinant tissue plasminogen activator within a treatment window 4.5 h after stroke induction. The aim present study was and quantify for hyperacute middle cerebral artery occlusion (MCAO) by measuring apparent diffusion coefficient (ADC) diffusion‑weighted (DWI) 1H‑magnetic...
Abstract The diagnosis and pathology of neuropsychiatric systemic lupus erythematosus (NPSLE) remains challenging. Herein, we used multimodal imaging to assess anatomical functional changes in brains SLE patients instead a single MRI approach generally previous studies. Twenty-two NPSLE patients, 21 non-NPSLE 20 healthy controls (HCs) underwent 3.0 T with multivoxel magnetic resonance spectroscopy, T1-weighted volumetric images for voxel based morphometry (VBM) diffusional kurtosis (DKI)...
Progress in the development of stem cell and gene therapy requires repeatable non‑invasive techniques to monitor survival integration cells vivo with a high temporal spatial resolution. The purpose present study was examine feasibility using standard contrast agent gadolinium diethylenetriamine pentaacetic acid (Gd‑DTPA) label rat mesenchymal (MSCs) for tracking. MSCs, obtained from bilateral femora rats, were cultured propagated. non‑liposomal lipid transfection reagent effectene then used...
Diffusional kurtosis imaging (DKI) is a new type diffusion-weighted sequence which measures the non-Gaussianity of water diffusion. The present study aimed to investigate whether parameters DKI could distinguish between differences in molecule diffusion various brain regions under conditions acute infarction and identify optimal parameter for locating ischemic lesions each region. A total 28 patients with stroke different were recruited study. relative values selected as major assessment...
We developed a novel magnetic resonance imaging (MRI) technique based on chemical exchange saturation transfer (CEST) for GABA and investigated the concentration-dependent CEST effect ofGABA in rat model of brain tumor with blood-brain barrier (BBB) disruption.All MRI studies were performed using 7.0-T Agilent scanner. Z-spectra acquired at 7.0 T, 37°C, pH varying B1 amplitudes. images phantoms different concentrations solutions (pH, 7.0) other metabolites (glutamine, myoinositol,...
The molecular mechanisms that regulate progressive pulmonary fibrosis remain poorly understood. Type 2 alveolar epithelial cells (AEC2s) function as adult stem in the lung. We previously showed there is a loss of AEC2s and failure AEC2 renewal lungs idiopathic (IPF) patients. also reported beta-arrestins are key regulators fibroblast invasion, beta-arrestin 1 deficient mice exhibit decreased mortality, matrix deposition, increased lung bleomycin-induced fibrosis. However, role regeneration...
Chemical exchange saturation transfer (CEST) is an emerging MRI contrast mechanism that capable of noninvasively imaging dilute CEST agents and local properties such as pH temperature, augmenting the routine methods. However, includes a long RF pulse followed by fast image readout, which associated with high specific absorption rate limited spatial resolution. In addition, echo planar (EPI)-based readout prone to distortion, particularly severe at field. To address these limitations, we...
The aim of this study is to describe the acute effects EtOH on brain edema and cerebral metabolites, using diffusion weight imaging (DWI) proton magnetic resonance spectroscopy ((1)H-MRS) at a 7.0T MR define changes in apparent coefficient (ADC) values concentration metabolites rat after intoxication. ADC each ROI decreased significantly 1 h 3 ethanol administration. frontal lobe were compared with other regions h. For EtOH/Cr+PCr (Cho, Tau, Glu) differing over time, no significant...
Video-assisted thoracic surgery (VATS) is a minimally invasive technique for the diagnosis and management of small pulmonary nodular lesions However, identification some lung nodules remains difficult.This research aimed to investigate clinical value preoperative computed tomography (CT)-guided hookwire localization solitary (SPNs) thoracoscopic resection.Seventy-one patients with 74 SPNs underwent VATS wedge resection after CT-guided localization. The mean diameter was 8.50 ± 4.53...
To delineate the features of multi-detector computed tomography (MDCT) images and clinical characteristics pancreatic solid pseudopapillary tumors (SPTs) pancreas in asymptomatic patients compare these between symptomatic patients. This work is a retrospective study approved by our institutional review board. MDCT data 109 with pathologically proven SPTs obtained from October 2008 to 2016 were reviewed. Patients categorized into two groups: disease. Cases reviewed determine reason for...
Dysfunction of the glymphatic system may play a significant role in development neurodegenerative diseases. However, vivo imaging is challenging. In this study, we describe an unconventional MRI method for based on chemical exchange saturation transfer, which tested porcine model impaired function. The blood, lymph, and cerebrospinal fluid (CSF) from one pig were used testing effect vitro at 7 Tesla (T). Unilateral deep cervical lymph node ligation models then performed 20 adult male...
In the progression of ischemia, pH is important and essential in elucidating association between metabolic disruption, lactate formation, acidosis tissue damage. Chemical exchange‑dependent saturation transfer (CEST) imaging can be used to detect and, particular, a specific form CEST magnetic resonance (MRI), termed amide proton (APT) MRI, which sensitive ischemic lesions, even prior diffusion abnormalities. The critical parameter governing ability sequence. present study, novel strategy was...