A5017386889- Advanced MRI Techniques and Applications
- Lanthanide and Transition Metal Complexes
- Electron Spin Resonance Studies
- Advanced Neuroimaging Techniques and Applications
- Fractal and DNA sequence analysis
- Machine Learning in Bioinformatics
- RNA and protein synthesis mechanisms
- Cardiac Imaging and Diagnostics
- Antibiotic Resistance in Bacteria
- Neurological disorders and treatments
- Radioactive element chemistry and processing
- Non-Destructive Testing Techniques
- Software Testing and Debugging Techniques
- Animal Virus Infections Studies
- Influenza Virus Research Studies
- MRI in cancer diagnosis
- Amoebic Infections and Treatments
- Systemic Lupus Erythematosus Research
- Educational Technology and Assessment
- Pharmaceutical and Antibiotic Environmental Impacts
- Cardiovascular Function and Risk Factors
- Atomic and Subatomic Physics Research
- Head and Neck Surgical Oncology
- Magnetism in coordination complexes
- Respiratory viral infections research
Shantou University
2015-2025
Second Affiliated Hospital of Shantou University Medical College
2016-2025
Shandong Agricultural University
2022-2024
Shantou University Medical College
2015
The imbalance of glutamate (Glu) and gamma-aminobutyric acid (GABA) neurotransmitter system plays a crucial role in the pathogenesis Alzheimer's disease (AD). Riluzole is Glu modulator originally approved for amyotrophic lateral sclerosis that has shown potential neuroprotective effects various neurodegenerative disorders. However, whether riluzole can improve GABA homeostasis AD brain its related mechanism action remain unknown. This study utilized chemical exchange saturation transfer...
Animal-derived Proteus mirabilis (P. mirabilis) is an important food-borne zoonotic bacillus and widely exists in the broiler-breeding industry. The present study was designed to explore P. prevalence antimicrobial resistance characteristics 6 conventional broiler-fattening farms Shandong Province, China. overall isolation rate of 7.07% (50/707). Antimicrobial very common isolated from these varied for different antibacterial drugs, with chloramphenicol, ciprofloxacin,...
To explore the capability of amide-proton-transfer weighted (APTW) magnetic resonance imaging (MRI) in evaluation clinical neurological deficit at time hospitalization and assessment long-term daily functional outcome for patients with acute ischemic stroke (AIS). We recruited 55 AIS brain MRI acquired within 24-48 hours symptom onset followed up their 90-day modified Rankin Scale (mRS) score. APT was performed all study subjects to measure APTW signal quantitatively area (APTWipsi)...
Keywords: Extracellular pH, Ioversol, CEST MRI, Hepatic carcinoma, hemangioma. Purpose: In this study, we aimed to use 3T magnetic resonance imaging (MRI), which is clinically available, determine the extracellular pH (pHe) of liver tumors and prospectively evaluate ability chemical exchange saturation transfer (CEST) MRI distinguish between benign malignant tumors. Methods: Different radiofrequency irradiation schemes were assessed for ioversol-based measurements at 3T. effects quantified...
A correlation between the abnormal cerebral glucose metabolism and progression of Alzheimer’s disease (AD) has been found in previous studies, suggesting that alterations may be used to predict histopathological diagnosis AD. In this study, we investigated dynamic changes uptake vivo using MR chemical exchange saturation transfer (glucoCEST) imaging a rat model AD with an intracerebroventricular (i.c.v) injection amyloid Aβ-protein (25–35), confirmed by Morris water maze Nissl staining....
Purpose: Detecting changes in reactive oxygen species (ROS) is critical for understanding its role brain health and diseases. We assumed that GSH-thiol-weighted imaging could potentially reflect subtle the ROS microenvironment. In this study, we aimed to investigate capability of via VDMP-CEST detecting alterations within brain. Methods: To develop a new technique image GSH-thiol, phantoms different GSH concentrations under acidic weakly alkaline conditions were performed using MRI CEST...
Abstract The diagnosis and pathology of neuropsychiatric systemic lupus erythematosus (NPSLE) remains challenging. Herein, we used multimodal imaging to assess anatomical functional changes in brains SLE patients instead a single MRI approach generally previous studies. Twenty-two NPSLE patients, 21 non-NPSLE 20 healthy controls (HCs) underwent 3.0 T with multivoxel magnetic resonance spectroscopy, T1-weighted volumetric images for voxel based morphometry (VBM) diffusional kurtosis (DKI)...
We aimed to evaluate microscale changes in the bilateral red nucleus and substantia nigra of patients with Parkinson's disease (PD) using diffusion kurtosis imaging (DKI). Twenty-six PD (mean age: 62.5 ± 8.7 years, Hoehn-Yahr stage: 0-4.0, Unified Disease Rating Scale (UPDRS) scores: 8-43) 15 healthy controls 59.5 9.4 years) underwent DKI nucleus. Imaging was performed a General Electric (GE) Signa 3.0 Tesla MR System. Patients were divided into two groups consisting 12 UPDRS scores ≥30 14...
Nuclear Overhauser enhancement (NOE) is a type of magnetization transfer using cross‐relaxation. It originates from mobile macromolecules, which may have relevance to the evaluation tumor features. We studied value NOE imaging at 7 and 3 T suggest utility for diagnosing human brain tumors. Two types protein solution different concentrations pH values, six normal Sprague Dawley (SD) rats, were used detect signal with scanner. Then, healthy volunteers 11 patients tumors (six gliomas five...
Background: Chemical exchange saturation transfer (CEST) is an important contrast mechanism in the field of magnetic resonance imaging. Herein, we used CEST for glutamate (GluCEST) imaging to evaluate Glu alterations acute mild moderate traumatic brain injury (TBI) and correlated such with cognitive outcome at 1-month postinjury. Methods: Thirty-two patients well-documented mild-to-moderate TBI 15 healthy controls (HC group) underwent 3.0-Tesla (MRI) GluCEST, spectroscopy (MRS) scans. The...
To analyze the clinical features and magnetic resonance imaging (MRI) findings of intracranial tuberculomas retrospectively. Brain MRIs in ten patients with were retrospectively reviewed. The diagnosis tuberculoma was based on histopathology or effects anti-tuberculosis therapy. data MRI these analyzed Our consisted six women four men, age ranged from 12 to 54 years old. data, such as symptoms signs, CSF examination, evidence extral-CNS tuberculosis immunocompetency, discussed. had been...
Porcine circovirus type 2 (PCV2) has been recognized as a critical pathogen associated with numerous porcine circovirus-related diseases. Immunization is commonly regarded the most efficient method to combat PCV2 infection. The virus's main antigen Cap protein, which encoded by ORF2 gene. In this investigation, we cloned gene into pYA3681 plasmid and subsequently electrotransferred it delayed lysis Salmonella strain χ11802, ultimately generating χ11802 (pYA3681-Cap) vaccine candidate strain....
Glioma is a malignant neoplasm affecting the central nervous system. The conventional approaches to diagnosis, such as T1-weighted imaging (T1WI), T2-weighted (T2WI), and contrast-enhanced T1WI, give an oversimplified representation of anatomic structures. Nuclear Overhauser enhancement (NOE) special form magnetization transfer (MT) that provides new way detect small solute pools through indirect measurement attenuated water signals, makes it possible probe semisolid macromolecular protons....
The detection of short exons is a challenging open problem in the field bioinformatics. Due to fact that weakness existing model-independent methods lies their inability reliably detect small exons, method based on singularity with wavelet transform modulus maxima has been developed for detecting coding sequences (exons) eukaryotic DNA sequences. In analysis our method, local can capture and characterize singularities which helps yield significant patterns are rarely observed traditional...
To analyze the chest X-ray and computed tomography (CT) findings of human infection with avian-origin influenza H7N9 virus from a hospital. Chest or CT was performed in five patients avian within 2 weeks after onset. The imaging data characteristics were analyzed retrospectively. Abnormal shown on images all patients. main abnormal included ground-glass opacities (GGOs) cases, consolidations air bronchograms pleural effusion four In early onset patients, right lobe more commonly affected...