A5048919432- Advanced MRI Techniques and Applications
- Lanthanide and Transition Metal Complexes
- Parkinson's Disease Mechanisms and Treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Advanced Neuroimaging Techniques and Applications
- Neurological disorders and treatments
- Dementia and Cognitive Impairment Research
- Glioma Diagnosis and Treatment
- Stress Responses and Cortisol
- Traumatic Brain Injury and Neurovascular Disturbances
- Electron Spin Resonance Studies
- Glaucoma and retinal disorders
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Infectious Encephalopathies and Encephalitis
- Functional Brain Connectivity Studies
- Medical Imaging Techniques and Applications
- Anesthesia and Neurotoxicity Research
- Cerebral Venous Sinus Thrombosis
- Ocular Diseases and Behçet’s Syndrome
- Cerebrovascular and Carotid Artery Diseases
- Retinal Diseases and Treatments
- MRI in cancer diagnosis
- Adipose Tissue and Metabolism
- Bipolar Disorder and Treatment
Second Affiliated Hospital of Shantou University Medical College
2012-2025
Shantou University
2016-2025
Fuyang City People's Hospital
2024
Second Affiliated Hospital of Harbin Medical University
2024
Harbin Medical University
2024
Shantou University Medical College
2006-2022
Shandong Eye Hospital
2022
Shandong First Medical University
2022
Affiliated Eye Hospital of Wenzhou Medical College
2018-2021
Wenzhou Medical University
2018-2021
Abstract This study aimed to analyse cerebral grey matter changes in mild cognitive impairment (MCI) using voxel-based morphometry and diagnose early Alzheimer's disease deep learning methods based on convolutional neural networks (CNNs) evaluating these changes. Participants (111 MCI, 73 normal cognition) underwent 3-T structural magnetic resonance imaging. The obtained images were assessed morphometry, including extraction of matter, analyses statistical differences, correlation between...
Objectives Bipolar disorder ( BD ) is a mental characterized by periods of elevated mood and depression. Many individuals with are initially misdiagnosed treated for unipolar depression UD ). In this study, we report direct comparisons between medication‐free those in terms the neurometabolites anterior cingulate cortex ACC ), medial prefrontal mPFC parietal PC posterior PCC brain. Methods Participants included patients or , matched healthy controls. All were depressive state had similar...
Stroke is the second leading cause of death globally and most common severe disability. Several barriers need to be addressed more effectively treat stroke, including efficient delivery therapeutic agents, rapid release at infarct site, precise imaging drug distribution monitoring. The present study aimed develop a bio-responsive theranostic nanoplatform with signal-amplifying capability deliver rapamycin (RAPA) ischemic brain tissues visually monitor distribution. A pH-sensitive RAPA-loaded...
Abstract INTRODUCTION The apolipoprotein E ( APOE ) ε4 allele exerts a significant influence on peripheral inflammation and neuroinflammation, yet the underlying mechanisms remain elusive. METHODS present study enrolled 54 patients diagnosed with late‐onset Alzheimer's disease (AD; including 28 carriers 26 non‐carriers). Plasma inflammatory cytokine concentration was assessed, alongside bulk RNA sequencing (RNA‐seq) single‐cell (scRNA‐seq) analysis of blood mononuclear cells (PBMCs). RESULTS...
Purpose: Detecting changes in reactive oxygen species (ROS) is critical for understanding its role brain health and diseases. We assumed that GSH-thiol-weighted imaging could potentially reflect subtle the ROS microenvironment. In this study, we aimed to investigate capability of via VDMP-CEST detecting alterations within brain. Methods: To develop a new technique image GSH-thiol, phantoms different GSH concentrations under acidic weakly alkaline conditions were performed using MRI CEST...
BackgroundGlioblastoma multiforme (GBM) is a fatal disease without effective therapy. Identification of new biomarkers for prognosis would enable more rational selections strategies to cure patients with GBM and prevent relapse.MethodsSeven datasets derived from using microarray or next generation sequencing in R2 online database (http://r2.amc.nl) were extracted then analyzed JMP software. The survival distribution was calculated according the Kaplan-Meier method significance determined...
Keywords: Extracellular pH, Ioversol, CEST MRI, Hepatic carcinoma, hemangioma. Purpose: In this study, we aimed to use 3T magnetic resonance imaging (MRI), which is clinically available, determine the extracellular pH (pHe) of liver tumors and prospectively evaluate ability chemical exchange saturation transfer (CEST) MRI distinguish between benign malignant tumors. Methods: Different radiofrequency irradiation schemes were assessed for ioversol-based measurements at 3T. effects quantified...
Pathologic ocular neovascularization commonly results in visual impairment or even blindness numerous fundus diseases, including proliferative diabetic retinopathy (PDR), of prematurity (ROP), and age-related macular degeneration (AMD). MicroRNAs regulate angiogenesis through modulating target genes disease progression, making them a new class targets for drug discovery. In this study, we investigated the potential role miR-18a-5p retinal using mouse model oxygen-induced (OIR). We found that...
Brain iron deposition and microstructural changes in brain tissue are associated with Parkinson's disease (PD). However, the correlation between these factors has been little studied. This study aimed to use quantitative susceptibility mapping combined diffusion kurtosis imaging investigate effects of on alterations brain.Quantitative were performed 24 patients early PD, 13 advanced 25 healthy controls. The mean values magnetic calculated for bilateral substantia nigra, red nucleus, putamen,...
We aim to explore the microstructural and metabolic changes in visual pathways patients with thyroid eye disease (TED) using 3T multi-parametric MRI.
Early diagnosis is currently the most effective way of saving life patients with neuropsychiatric systemic lupus erythematosus (NPSLE). However, it rather difficult to detect this terrible disease at early stage, due subtle and elusive symptomatic signals. Recent studies show that 1H-MRS (proton magnetic resonance spectroscopy) imaging technique can capture more information reflecting appearance than conventional techniques. data, however, also presents noises bring serious bias. We hence...
Credible and accurate traffic flow forecasting is critical for deploying intelligent management systems. Nevertheless, it remains challenging to develop a robust efficient model due the nonlinear characteristics inherent stochastic flow. Aiming at relationship in different scenarios, we proposed two-stage hybrid extreme learning short-term forecasting. In first stage, particle swarm optimization algorithm employed determining initial population distribution of gravitational search improve...
Abstract Background Nanomedicine is a promising new approach to cancer treatment that avoids the disadvantages of traditional chemotherapy and improves therapeutic indices. However, lack real-time visualization imaging technology monitor drug distribution greatly limits its clinical application. Image-tracked delivery great interest; it useful for identifying those patients whom therapy more likely be beneficial. This paper discusses novel nanomedicine displays features nanoparticles...
We aimed to evaluate microscale changes in the bilateral red nucleus and substantia nigra of patients with Parkinson's disease (PD) using diffusion kurtosis imaging (DKI). Twenty-six PD (mean age: 62.5 ± 8.7 years, Hoehn-Yahr stage: 0-4.0, Unified Disease Rating Scale (UPDRS) scores: 8-43) 15 healthy controls 59.5 9.4 years) underwent DKI nucleus. Imaging was performed a General Electric (GE) Signa 3.0 Tesla MR System. Patients were divided into two groups consisting 12 UPDRS scores ≥30 14...
Early life stress (ELS) is associated with an increased risk of developing depression and anxiety disorders. Disturbances the neurobiological glutamatergic system are implicated in depression; however, long-term effects ELS on glutamate (Glu) metabolites remain unclear. Our study used 7T proton magnetic resonance spectroscopy (7T 1H MRS) to detect metabolic Glu a rat model investigate maternal deprivation (MD)-induced ELS. MD was established Sprague–Dawley rats by periodic separation from...
Abstract Diabetic retinopathy (DR) is a diabetes-associated complication that poses threat to vision, distinguished by persistent and mild inflammation of the retinal microvasculature. The activation microglia plays crucial role in driving this pathological progression. Previous investigations have demonstrated ubiquitin-specific peptidase 25 (USP25), deubiquitinating enzyme, involved regulation immune cell activity. Nevertheless, precise mechanisms through which USP25 contributes...
Abstract The brain presents age-related structural and functional changes in the human life, with different extends between subjects groups. Brain age prediction can be used to evaluate development aging of brain, as well providing valuable information for neurodevelopment disease diagnosis. Many contributions have been made this purpose, resorting machine learning methods. To solve task reduce memory resource consumption, we develop a mini architecture only 10 layers by modifying deep...
Nuclear Overhauser enhancement (NOE) is a type of magnetization transfer using cross‐relaxation. It originates from mobile macromolecules, which may have relevance to the evaluation tumor features. We studied value NOE imaging at 7 and 3 T suggest utility for diagnosing human brain tumors. Two types protein solution different concentrations pH values, six normal Sprague Dawley (SD) rats, were used detect signal with scanner. Then, healthy volunteers 11 patients tumors (six gliomas five...
The diagnostic performance difference between digital breast tomosynthesis (DBT) and conventional full-field mammography (FFDM) for suspicious calcifications from various populations is unclear. objective of this study to determine whether DBT exhibits the advantage compared with FFDM. Three hundred five patients were enrolled (of which seven bilateral lesions) 312 breasts images retrospectively analyzed by three radiologists independently. postoperative pathology was gold standard. Breast...
The molecular complexity of neural retina development remains poorly studied. Knowledge retinal neurogenesis regulation sheds light on degeneration therapy exploration. Therefore, we integrated the time-series circRNA, lncRNA, miRNA, and mRNA expression profiles developing through whole-transcriptome sequencing. key functional ncRNAs ceRNA network regulating were identified.Transcriptomic analysis identified circRNA as most variable ncRNA subtype. We screened a series neurogenesis-related...
The reliable and dynamic detection of amyloid β-protein (Aβ) deposition using imaging technology is necessary for preclinical Alzheimer's disease (AD), which may significantly improve prognosis. present study aimed to evaluate the feasibility applying angiopep-2 (ANG), a chemical exchange saturation transfer-magnetic resonance (CEST-MRI) biomarker, monitoring Aβ in vivo. ANG exerted good transfer (CEST) effect displayed moderate binding affinity Aβ1–42 vitro. Six-month-old mice with AD...
Sepsis-associated encephalopathy is a severe systemic infection complication. Although early stages involve pathophysiological changes, detection using conventional imaging challenging. Glutamate chemical exchange saturation transfer and diffusion kurtosis can noninvasively investigate cellular molecular events in disease magnetic resonance (MRI). N-Acetylcysteine, an antioxidant precursor of glutathione, regulates neurotransmitter glutamate metabolism participates neuroinflammation. We...
Abstract Introduction The accurate diagnosis and monitoring of idiopathic Parkinson disease ( PD ), a progressive neurodegenerative disorder, has not been fully developed. This study sought to identify neurochemical profile in multiple regions the brain healthy controls by proton magnetic resonance spectroscopy 1 H‐ MRS ). We aimed track changes neurochemical, quantify neuronal loss, further determine diagnostic value . Methods patients recruited from Second Affiliated Hospital Shantou...