A5112535306- Adipose Tissue and Metabolism
- Birth, Development, and Health
- Nicotinic Acetylcholine Receptors Study
- Cholinesterase and Neurodegenerative Diseases
- Liver Disease Diagnosis and Treatment
- Diet and metabolism studies
- Chemical synthesis and alkaloids
- Mitochondrial Function and Pathology
- Diet, Metabolism, and Disease
- Lipid metabolism and biosynthesis
- Obesity, Physical Activity, Diet
- MicroRNA in disease regulation
- Angiogenesis and VEGF in Cancer
- Myofascial pain diagnosis and treatment
- Nuclear Receptors and Signaling
- Neuroscience and Neuropharmacology Research
- Pharmacology and Obesity Treatment
- Neurotransmitter Receptor Influence on Behavior
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Acupuncture Treatment Research Studies
- Metabolism and Genetic Disorders
- Epilepsy research and treatment
- Pregnancy and preeclampsia studies
Texas A&M University
2022-2024
Shantou University
2018-2024
First Affiliated Hospital of Shantou University Medical College
2024
Prevention Institute
2022-2024
Zhengzhou University
2018-2023
Chengdu University of Traditional Chinese Medicine
2020-2023
West China Second University Hospital of Sichuan University
2011-2022
Dignity Health
2018-2022
Nanjing Municipal Center for Disease Control And Prevention
2022
State Council of the People's Republic of China
2018-2022
Rationale: Exercise training, in addition to reducing cardiovascular risk factors, confers direct protection against myocardial ischemia/reperfusion injury and has been associated with improved heart attack survival humans. However, the underlying mechanisms of exercise-afforded cardioprotection are still unclear. Objective: To investigate role exercise-derived circulating exosomes molecular involved. Methods Results: Circulating were isolated from plasma volunteers or without exercise...
Abnormal metabolism of nonesterified fatty acids (NEFAs) and their derivatives has been reported to be the main cause intracellular lipotoxic injury. Normally, NEFAs are stored in lipid droplets (LDs) form triglyceride (TG), which could reduce lipotoxicity cytosolic NEFAs. Previous studies have implicated that Perilipin 5 (Plin5), an LD‐binding protein, regulates storage hydrolysis TG LD. However, its roles underlying mechanisms liver remain unknown. Here we found Plin5 expression was...
Angiogenesis constitutes a major mechanism responsible for exercise-induced beneficial effects. Our previous study identified cluster of differentially expressed extracellular vesicle microRNAs (miRNAs) after exercise and found that some them act as exerkines. However, whether these miRNAs mediate the angiogenesis remains unknown.A 9-day treadmill training was used an model in C57BL/6 mice. Liver-specific adeno-associated virus 8 to knock down microRNA-122-5p (miR-122-5p). Human umbilical...
Abstract INTRODUCTION The apolipoprotein E ( APOE ) ε4 allele exerts a significant influence on peripheral inflammation and neuroinflammation, yet the underlying mechanisms remain elusive. METHODS present study enrolled 54 patients diagnosed with late‐onset Alzheimer's disease (AD; including 28 carriers 26 non‐carriers). Plasma inflammatory cytokine concentration was assessed, alongside bulk RNA sequencing (RNA‐seq) single‐cell (scRNA‐seq) analysis of blood mononuclear cells (PBMCs). RESULTS...
Abstract Background The role of socioeconomic status (SES) on hypertension prevalence and control has gotten much attention but with conflicting results. This paper aimed to quantify the association SES both rate in Nanjing, China. Methods A community-based cross-sectional study was conducted using multistage random sampling 60,283 adults aged more than 18 years between March 2017 June 2018. Hypertension defined as systolic blood pressure (BP) ≥ 140 mmHg and/or diastolic BP 90 or...
Obesity is a major risk factor for metabolic syndrome, including insulin resistance (IR), type 2 diabetes mellitus (T2DM), and cardiovascular disease; ectopic fat deposition plays key role in the development of these conditions. In insulin-resistant and/or T2DM patients, lipid accumulation increased skeletal muscle; intramuscular fatty acid metabolites recognized to play critical syndrome. Besides improving sensitivity, anti-diabetic drug metformin can reduce however, its mechanism action...
Cell death-inducing DFF45-like effector b (Cideb), an endoplasmic reticulum (ER)- and lipid droplet (LD)-associated protein, has been shown to play a critical role in maintaining hepatic homeostasis by promoting the lipidation maturation of VLDL particles. Here, we observed that Cideb is expressed jejunum ileum sections small intestine, its expression was induced high-fat diet. Intragastric gavage with lipids resulted retention intestine Cideb-deficient mice. In addition, mice deficiency...
Pregnant women may transmit their metabolic phenotypes to offspring, enhancing the risk for nonalcoholic fatty liver disease (NAFLD); however, molecular mechanisms remain unclear.Prior pregnancy female mice were fed either a maternal normal-fat diet (NF-group, "no effectors"), or high-fat (HF-group, "persistent transitioned from HF NF before (H9N-group, "effectors removal"), followed by and lactation, then offspring diets after weaning. Offspring livers analysed functional studies, as well...
Abstract Background The dose–effect relationship of Long-snake-like moxibustion for chronic fatigue syndrome (CFS) remains poorly understood. In order to address this gap, we designed trial assess the association between different treatment duration and its effects on CFS based combination measurements subjective patient-reported scales with objective medical infrared imaging technology─Thermal Texture Maps (TTM). Methods From December 2020 January 2022, 60 female patients were recruited...
To examine whether environmental interventions, student awareness and parents' model roles are associated with the consumption of sugar-sweetened beverages (SSBs), a randomized controlled trial was conducted among Chinese schoolchildren. A multi-stage cluster random sampling method applied to select four primary schools, two in urban areas rural areas, Nanjing, eastern China. Classes third grade selected schools were randomly assigned intervention group control group. Among students those...
The high-quality development of society needs the support resource and environmental carrying capacity, improvement capacity is driven by process development. Therefore, how to realize dynamic coordination two an urgent problem be solved. Different from previous studies which mainly focused on economic environment, this paper considers all aspects analyzes interactive relationship between for first time. Based panel data 30 provinces in China 2005 2020, a comprehensive evaluation index...
Nonverbal cognitive training for aphasia has gained popularity. Prior research found that status correlates with language function.To determine whether nonverbal computer-assisted executive control (CAET) to improve affects performance in patients (PWA) and dysfunction.A single blind randomized trial.Department of Rehabilitation, Affiliated Hospital Xuzhou Medical University.A total 68 individuals were randomized, underwent treatment included the analysis (CAET group, n = 33; 35).The...
Recent studies have suggested that prevention of obesity and non-alcoholic fatty liver disease (NAFLD) should start with maternal dietary management. We previously reported disrupted methionine cycle, associated NAFLD, in male offspring due to high-fat (HF) diet, thus we hypothesize one-carbon supplement may reduce the risk NAFLD via normalizing cycle. To test it, female mice (F0) were exposed either a normal-fat diet (NF group) HF (HF group), or methyl donor (H1S H2S during gestation...
Curative effect of magnesium sulfate combined with nifedipine on pregnancy-induced hypertension and the serum inflammatory factors were investigated. A total 188 cases patients collected as research subjects. They all had hypertension, admitted to The First People's Hospital Yunnan Province hospital from June 2016 February 2018. There were, 94 treated in control group, further study group. ELISA was used detect expression levels suppressors cytokine signaling-3 (SOCS-3), interleukin-10...
Invasive lobular carcinoma (ILC) of the breast is a rare type cancer. Metastatic ILC difficult to identify in sentinel lymph nodes (SLNs) because its low-grade cytomorphology and tendency resemble lymphocytes. Touch imprint cytology (TIC) rapid method for evaluating SLNs intraoperatively. We sought evaluate this technique identification SLN metastases ILC. A total 230 from 88 patients diagnosed with were examined TIC, results compared their histological diagnosis. first confirmed some...
We have recently reported that activation of cannabinoid type 2 receptors (CB2Rs) reduces dopamine (DA) neuron excitability in mouse ventral tegmental area (VTA). Here, we elucidate the underlying mechanisms. Using cell-attached recording VTA slices, bath-application CB2R agonists (JWH133 or five other agonists) significantly reduced DA action potential (AP) firing rate. Under patch-clamp whole-cell model, JWH133 (10 µM) mildly frequency miniature excitatory postsynaptic currents (mEPSCs)...
Objective To investigate the joint associations of fresh fruit intake and physical activity with glycaemic control in adult patients diabetes mellitus (DM). Design It was an observational study involving DM through a face-to-face questionnaire survey, measurements laboratory examinations. Data were analysed by introducing generalised linear mixed model, significant difference set at p<0.05. Setting Nanjing, Jiangsu, China. Participants A total 5663 from 2017 Nanjing Chronic Disease Risk...
Background/Objectives: This study builds on previous findings from mouse models, which showed that maternal overnutrition induced by a high-fat diet (HFD) promotes metabolic-associated fatty liver disease (MAFLD) in offspring, linked to global DNA hypermethylation. We explored whether epigenetic modulation with 5-Aza-CdR, methylation inhibitor, could prevent MAFLD offspring exposed overnutrition. Methods: The mice dams of were fed either chow or for 10 weeks. These randomly divided into two...