A5041499359- Parkinson's Disease Mechanisms and Treatments
- Neurological disorders and treatments
- Genetic Neurodegenerative Diseases
- Botulinum Toxin and Related Neurological Disorders
- Restless Legs Syndrome Research
- Alzheimer's disease research and treatments
- Advanced Neuroimaging Techniques and Applications
- Advanced MRI Techniques and Applications
- EEG and Brain-Computer Interfaces
- Functional Brain Connectivity Studies
- Neuroscience and Neural Engineering
- Neuroinflammation and Neurodegeneration Mechanisms
- Ginkgo biloba and Cashew Applications
- Balance, Gait, and Falls Prevention
- Conducting polymers and applications
- Cerebrovascular and Carotid Artery Diseases
- Spectroscopy and Chemometric Analyses
- Cerebral Palsy and Movement Disorders
- Protein Hydrolysis and Bioactive Peptides
- Sleep and Wakefulness Research
- Neurobiology of Language and Bilingualism
- Neurological diseases and metabolism
- Autism Spectrum Disorder Research
- Cardiovascular Syncope and Autonomic Disorders
- Traditional Chinese Medicine Studies
Capital Medical University
2016-2025
Beijing Tian Tan Hospital
2016-2025
National Clinical Research Center for Digestive Diseases
2016-2025
Xuzhou Medical College
2021-2025
Shanghai Institute of Technology
2025
Zhejiang University
2024-2025
Fujian University of Technology
2025
Ruijin Hospital
2024
Shanghai Jiao Tong University
2024
West China Medical Center of Sichuan University
2024
Erythrocytes are a major source of peripheral α-synuclein (α-Syn). The goal the current investigation is to evaluate erythrocytic total, oligomeric/aggregated, and phosphorylated α-Syn species as biomarkers Parkinson's disease (PD). PD healthy control blood samples were collected along with extensive clinical history determine whether phosphorylated, or aggregated derived from erythrocytes (the α-Syn) more promising consistent for than free in serum plasma. Using newly developed...
Abstract Transportation of key proteins via extracellular vesicles has been recently implicated in various neurodegenerative disorders, including Parkinson’s disease, as a new mechanism disease spreading and source biomarkers. Extracellular likely to be derived from the brain can isolated peripheral blood have reported contain higher levels α-synuclein (α-syn) patients. However, very little is known about multiple system atrophy, that, like involves pathological α-syn aggregation, though...
Abstract Freezing of gait is a debilitating symptom in advanced Parkinson’s disease and responds heterogeneously to treatments such as deep brain stimulation. Recent studies indicated that cortical dysfunction involved the development freezing, while evidence depicting specific role primary motor cortex multi-circuit pathology freezing lacking. Since abnormal beta-gamma phase-amplitude coupling recorded from patients with indicates parkinsonian state responses therapeutic stimulation, we...
Evidence regarding brain structural atrophy associated with Freezing of Gait (FOG) in Parkinson's disease (PD) is inconsistent. We analyzed cortical thickness and subcortical nuclei volumes using FreeSurfer two large PD cohorts. In cohort 1 (N = 316), multivariate analyses identified reduced pallidum ventral diencephalon (VDC) as significantly FOG presence. Validation the Progression Markers Initiative (PPMI) (cohort 2, N 94) demonstrated that decreased VDC volume at four-year follow-up...
To predict the global, regional, and national prevalence of Parkinson's disease by age, sex, year, Socio-demographic Index to 2050 quantify factors driving changes in cases. Modelling study. Global Burden Disease Study 2021. Prevalent number, all age standardised 2050, average annual percentage change from 2021 2050; contribution population ageing, growth, growth cases; attributable fractions for modifiable factors. 25.2 (95% uncertainty interval 21.7 30.1) million people were projected be...
Micrographia is a common symptom in Parkinson’s disease, which manifests as either consistent or progressive reduction the size of handwriting both. Neural correlates underlying micrographia remain unclear. We used functional magnetic resonance imaging to investigate micrographia-related neural activity and connectivity modulations. In addition, effect attention dopaminergic administration on was examined. found that associated with decreased basal ganglia motor circuit; while related...
Background Parkinson disease (PD) is a common movement disorder. Patients with PD have multiple gait impairments that result in an increased risk of falls and diminished quality life. Therefore, measurement important for the management PD. Objective We previously developed smartphone-based dual-task assessment was validated healthy adults. The aim this study to test validity people PD, examine association between app-derived metrics clinical functional characteristics Methods Fifty-two...
Immune system dysfunction, including higher levels of peripheral monocytes and inflammatory cytokines, is an important feature Parkinson's disease (PD) pathogenesis, although the mechanism underlying process remains to be investigated. In central nervous system, it well-known that α-synuclein (α-syn), a key protein involved in PD, activates microglia potently, also reported α-syn exists especially erythrocytes or red blood cells (RBC) at exceedingly high concentration. The current study...
The accumulation of α-synuclein (α-syn), an essential step in PD development and progression, is observed not only neurons but also glia, including astrocytes. mechanisms regulating astrocytic α-syn level aggregation remain unclear. More recently, it has been demonstrated that a part spreading occurs through extracellular vesicles (EVs), although unknown whether this process involved astrocytes PD. It known, however, EVs derived from the central nervous system exist blood are extensively...
Summary Aims Postural instability/gait difficulty ( PIGD ) and tremor‐dominant TD subtypes of Parkinson's disease PD show different clinical manifestations; however, their underlying neural substrates remain incompletely understood. This study aimed at investigating the subtype‐specific patterns spontaneous brain activity in . Methods Thirty‐one patients with (12 /19 22 healthy gender‐ age‐matched controls were recruited. Resting‐state functional magnetic resonance imaging data collected,...
Abstract Objective Evidence of abnormal α‐synuclein (α‐Syn) deposition in the brain is required for definitive diagnosis synucleinopathies, which remains challenging. The seed amplification assay (SAA) an innovative technique that can detect seeding activity misfolded α‐Syn, enabling and detection minute quantities pathogenic α‐Syn aggregates. This study aimed to evaluate oral mucosa SAA as possible diagnostic prodromal biomarkers synucleinopathies. Methods A total 107 Parkinson's disease...
Early and precise diagnosis of α-synucleinopathies is challenging but critical. In this study, we developed a molecular beacon-based assay to evaluate microRNA-containing extracellular vesicles (EVs) in plasma. We recruited 1203 participants including healthy controls (HCs) patients with isolated REM sleep behavior disorder (iRBD), α-synucleinopathies, or non-α-synucleinopathies from eight centers across China. Plasma miR-44438-containing EV levels were significantly increased those the...
Introduction Rehabilitation devices assist individuals with movement disorders by supporting daily activities and facilitating effective rehabilitation training. Accurate early motor intention detection is vital for real-time device applications. However, traditional methods of often rely on single-mode signals, such as EEG or EMG alone, which can be limited low signal quality reduced stability. This study proposes a multimodal fusion method based EEG–EMG functional connectivity to detect...
Abstract Background Freezing of gait (FOG) is a common disorder that often accompanies Parkinson's disease (PD). The current understanding brain functional organization in FOG was built on the assumption connectivity (FC) networks static, but FC changes dynamically over time. We aimed to characterize dynamic (DFC) patients with based high temporal‐resolution MRI (fMRI). Methods Eighty‐seven PD patients, including 29 and 58 without FOG, 32 healthy controls underwent resting‐state fMRI....