A5101501855- Cerebral Palsy and Movement Disorders
- Parkinson's Disease Mechanisms and Treatments
- Balance, Gait, and Falls Prevention
- Stroke Rehabilitation and Recovery
- Sleep and related disorders
- Mental Health Research Topics
- Dementia and Cognitive Impairment Research
- Sleep and Wakefulness Research
- Vascular Malformations Diagnosis and Treatment
- Lymphoma Diagnosis and Treatment
- Intensive Care Unit Cognitive Disorders
- Memory and Neural Mechanisms
- Restless Legs Syndrome Research
- Cutaneous lymphoproliferative disorders research
- IL-33, ST2, and ILC Pathways
- Intracerebral and Subarachnoid Hemorrhage Research
- Immune Cell Function and Interaction
- Muscle and Compartmental Disorders
- Vascular Procedures and Complications
- Neuroscience and Neuropharmacology Research
- Central Venous Catheters and Hemodialysis
- Viral-associated cancers and disorders
- Functional Brain Connectivity Studies
- Respiratory Support and Mechanisms
- Digital Mental Health Interventions
Shandong First Medical University
2024
Shandong Tumor Hospital
2024
Shandong University
2023-2024
Chinese Institute for Brain Research
2022-2024
Capital Medical University
2015-2024
Vanderbilt University Medical Center
2017-2022
Beijing Tian Tan Hospital
2015-2022
Capital University
2013
Background Major depressive disorder (MDD) is a common mental illness characterized by persistent sadness and loss of interest in activities. Using smartphones wearable devices to monitor the condition patients with MDD has been examined several studies. However, few studies have used passively collected data mood changes over time. Objective The aim this study examine feasibility monitoring status stability using machine learning models trained data, including phone use sleep step count...
Background Parkinson disease (PD) is a common movement disorder. Patients with PD have multiple gait impairments that result in an increased risk of falls and diminished quality life. Therefore, measurement important for the management PD. Objective We previously developed smartphone-based dual-task assessment was validated healthy adults. The aim this study to test validity people PD, examine association between app-derived metrics clinical functional characteristics Methods Fifty-two...
Granulomatous slack skin (GSS) is an extremely rare subtype of cutaneous T-cell lymphoma accompanied by abundant number macrophages and clinically characterized the development pendulous folds. However, characteristics these in GSS remain unclear. Here, we conducted a spatial transcriptomic study on one frozen sample drew maps for first time. Gene expression analysis revealed enrichment three clusters with macrophage transcripts, each exhibiting distinct suggesting that their primary...
The impact of poor sleep quality after stroke, especially persistent quality, on poststroke anxiety and depression is unclear. We seek to investigate the baseline short-term depression.Data were analyzed for 1619 patients with acute ischemic stroke from Impairment Cognition Sleep Acute Ischemic Stroke or Transient Attack in Chinese Patients study (ICONS). was assessed at 2 weeks 3 months using Pittsburgh Quality Index scale (PSQI). Poor defined as a PSQI score >5, >5 each time point. divided...
The Functional Gait Assessment (FGA) is a validated measurement of gait-related activities in certain populations and may be potentially useful to assess balance gait disorders patients with Parkinson disease (PD).The purpose this study was determine the construct, concurrent, predictive validity FGA inpatients PD.This prospective cohort study.One hundred twenty-one PD were prospectively enrolled. other relevant appraisals gait, balance, severity, daily living performed. Six months later,...
Objective: Cognitive symptoms in major depressive disorder (MDD) are common and may negatively impact clinical functional outcomes. The Prospective Research Observation to Assess Cognition Treated patients with MDD (PROACT) study aimed assess the prevalence course of cognitive symptoms, their associations outcomes during 6 months antidepressant treatment, a real-world setting among Chinese MDD. Patients methods: Outpatients (n=598) aged 18-65 years total score ≥17 on Hamilton Depression...
Background Memory consolidation in sleep-dependent individuals involves the circuitry connections of cortex, thalamus and hippocampus, regulating via neural metabolites. However, disruption metabolic pattern hippocampus remains unclear. Objective We aim to explore disruptive effects insomnia on metabolites during memory consolidation, particularly underlying neurometabolic mechanisms comorbidity failed consolidation. Methods This study integrates clinical research with animal experiment. In...
Background: Although sleep disorders significantly increase the risk of cognitive impairment, literature is relatively scarce regarding impact status on function in patients with acute ischemic stroke (AIS). We seek to study association between pre-stroke subjective and at 3 months after stroke. Patients methods: Data were analyzed for 1,759 AIS from Impairment Cognition Sleep Acute Ischemic Stroke or Transient Attack Chinese Study (ICONS). Pre-stroke was assessed by Pittsburgh Quality Index...
Jackson, Karen; Wang, Chunxue; McNeil, Joel; Shaver, Ciara; Warren, Melissa; Bastarache, Julie; Ware, Lorraine Author Information
<sec> <title>BACKGROUND</title> Parkinson disease (PD) is a common movement disorder. Patients with PD have multiple gait impairments that result in an increased risk of falls and diminished quality life. Therefore, measurement important for the management PD. </sec> <title>OBJECTIVE</title> We previously developed smartphone-based dual-task assessment was validated healthy adults. The aim this study to test validity people PD, examine association between app-derived metrics clinical...
<sec> <title>UNSTRUCTURED</title> N/A </sec>