A5077989094- Mental Health Research Topics
- Treatment of Major Depression
- Tryptophan and brain disorders
- Functional Brain Connectivity Studies
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Mental Health Treatment and Access
- Bipolar Disorder and Treatment
- Schizophrenia research and treatment
- Maternal Mental Health During Pregnancy and Postpartum
- Child and Adolescent Psychosocial and Emotional Development
- Digital Mental Health Interventions
- Stress Responses and Cortisol
- Sleep and related disorders
- Eating Disorders and Behaviors
- Topic Modeling
- Transcranial Magnetic Stimulation Studies
- Web Data Mining and Analysis
- Neuroinflammation and Neurodegeneration Mechanisms
- Neurogenesis and neuroplasticity mechanisms
- Obstructive Sleep Apnea Research
- HIV, Drug Use, Sexual Risk
- Dental Erosion and Treatment
- Psychiatric care and mental health services
- Healthcare Decision-Making and Restraints
- Perfectionism, Procrastination, Anxiety Studies
Capital Medical University
2015-2025
Beijing Anding Hospital
2015-2025
The First Hospital of Changsha
2024
Central South University
2024
National Clinical Research
2018-2022
Hunan University
2019
Institute of Psychology, Chinese Academy of Sciences
2018
Chinese University of Hong Kong
2015
The University of Western Australia
2015
University of Macau
2015
The authors compared measurement-based care with standard treatment in major depression.Outpatients moderate to severe depression were consecutively randomized 24 weeks of either (guideline- and rating scale-based decisions; N=61), or (clinicians' choice N=59). Pharmacotherapy was restricted paroxetine (20-60 mg/day) mirtazapine (15-45 both groups. Depressive symptoms measured the Hamilton Depression Rating Scale (HAM-D) Quick Inventory Symptomatology-Self-Report (QIDS-SR). Time response (a...
The nucleus accumbens (NAc) is an important region in reward circuit that has been linked with anhedonia, which a characteristic symptom of major depressive disorder (MDD). However, the relationship between functional connectivity NAc subregions and anhedonia MDD patients remains unclear.
Background Major depressive disorder (MDD) is a common mental illness characterized by persistent sadness and loss of interest in activities. Using smartphones wearable devices to monitor the condition patients with MDD has been examined several studies. However, few studies have used passively collected data mood changes over time. Objective The aim this study examine feasibility monitoring status stability using machine learning models trained data, including phone use sleep step count...
Cholesterol, an essential component of all mammalian plasma membranes, is highly enriched in the brain. Both during development and adult, brain cholesterol derived from local synthesis not taken up circulation. However, contribution neurons glial cells to total metabolism unknown. Using conditional gene inactivation mouse, we disrupted squalene synthase (fdft1), which critical for synthesis, cerebellar granule some precerebellar nuclei. Mutant mice showed no histological signs neuronal...
Exposure to childhood abuse has been identified as a salient risk factor for the development of depression. However, mediating factors between and depressive symptoms have not sufficiently elucidated. This study aims investigate effects neuroticism, social support, coping style in population covering general adults, depressed patients, bipolar disorder high depression.This is cross-sectional study. Five validated questionnaires were used measure psychological outcomes (Childhood Trauma...
It is important to timely capture the fluctuation of symptoms related major depressive disorder (MDD). However, most conventionally used assessment tools for MDD are not designed real-time assessment. The Immediate Mood Scaler (IMS) suitable evaluation mood patients with MDD. original IMS was translated into Chinese and back-translated. At baseline, data from 368 MDD, including demographic information scores on Patient Health Questionnaire-9 (PHQ-9), Generalized Anxiety Disorder-7 (GAD-7),...
Abstract Background The relationship between emotional symptoms and cognitive impairments in major depressive disorder (MDD) is key to understanding dysfunction optimizing recovery strategies. This study investigates the subjective objective functions MDD evaluates their contributions social functioning recovery. Methods Prospective Cohort Study of Depression China (PROUD) involved 1,376 patients, who underwent 8 weeks antidepressant monotherapy with assessments at baseline, week 8, 52....
Major depressive disorder (MDD) affects >163 million people worldwide and is a leading cause of disability in China. Functional impairment occurs alongside cognitive symptoms, anxiety, depression, reducing quality life productivity patients with MDD.The multimodal antidepressant vortioxetine has demonstrated efficacy relieving functional symptoms MDD randomized controlled trials (RCTs). The RELIEVE China study aimed to investigate the real-world effectiveness China.This was an observational,...
Objectives: The function of the Hypothalamic–Pituitary–Adrenal (HPA) axis during opioid dependence has been inconsistent. We compared HPA measures between subjects methadone stabilization and drug-free detoxification with healthy controls. Methods: Sixty heroin dependent patients received either non-opiate treatment (NOT) benzodiazepines clonidine (n = 30) or (MT, n 30), their serum levels corticotropin releasing hormone (CRH), adrenocorticotropic (ACTH), cortisol (COR) were measured to...
Major depressive disorder (MDD) is a prevalent mental health condition and has become pressing societal challenge. Early prediction of treatment response may aid in the rehabilitation engineering depression, which great practical significance for relief suffering burden MDD. In this paper, we present sequence modeling approach that uses data collected by passive sensing techniques to predict patients with an outcome responded defined reduction clinical administrated scales. Hundreds MDD have...
Background This study aims to investigate the factors associated with sexual dysfunction (SD), a particular focus on influence of sex occurrence and severity this condition in patients major depressive disorder (MDD). Method Sociodemographic clinical assessments were conducted 273 MDD (female = 174, male 99), including ASEX, QIDS-SR16, GAD-7, PHQ-15. Univariate analyses, independent samples t -test, Chi-square test, Fisher’s exact test used as appropriate, logistic regression analysis was...
In the population of postmenopausal patients with major depressive disorder (MDD), superiority serotonin-norepinephrine reuptake inhibitors (SNRIs) over selective serotonin (SSRIs) has not yet been definitively proven. Consequently, a direct comparison efficacy SSRIs and SNRIs in treatment depression could provide relevant data. The aim this study was to compare safety venlafaxine vs. fluoxetine MDD.This an 8-week, multicenter, randomized, single-blind, active-controlled trial conducted at...
Abstract Background Depressive symptoms, functional impairment, and decreased quality of life (QOL) are three important domains major depressive disorder (MDD). However, the possible causal relationship between these factors has yet to be elucidated. Moreover, it is not known whether certain symptoms MDD more impairing than others. The network approach a promising solution shortfalls. Methods baseline data multicenter prospective project conducted in 11 governances China were analyzed. In...