A5042800587- Neurological disorders and treatments
- Parkinson's Disease Mechanisms and Treatments
- Gastric Cancer Management and Outcomes
- Transcranial Magnetic Stimulation Studies
- Neuroscience and Neural Engineering
- Genetic Neurodegenerative Diseases
- Neuroscience and Neuropharmacology Research
- EEG and Brain-Computer Interfaces
- Food Drying and Modeling
- Gastrointestinal Tumor Research and Treatment
- Metastasis and carcinoma case studies
- Epilepsy research and treatment
- Microencapsulation and Drying Processes
- Botulinum Toxin and Related Neurological Disorders
- Obsessive-Compulsive Spectrum Disorders
- Cancer-related molecular mechanisms research
- Parasitic Infections and Diagnostics
- Neurogenesis and neuroplasticity mechanisms
- Esophageal Cancer Research and Treatment
- Circular RNAs in diseases
- Helicobacter pylori-related gastroenterology studies
- Phytochemicals and Antioxidant Activities
- Postharvest Quality and Shelf Life Management
- Neural dynamics and brain function
- Protease and Inhibitor Mechanisms
Beijing Tian Tan Hospital
2016-2025
Capital Medical University
2016-2025
Harbin Medical University
2009-2025
Third Affiliated Hospital of Harbin Medical University
2016-2025
Beijing Institute of Neurosurgery
2017-2024
Yanshan University
2023-2024
Jiangnan University
2018-2022
Jiangsu University of Science and Technology
2020-2022
Beijing University of Agriculture
2022
China People's Public Security University
2021
Abstract Freezing of gait is a debilitating symptom in advanced Parkinson’s disease and responds heterogeneously to treatments such as deep brain stimulation. Recent studies indicated that cortical dysfunction involved the development freezing, while evidence depicting specific role primary motor cortex multi-circuit pathology freezing lacking. Since abnormal beta-gamma phase-amplitude coupling recorded from patients with indicates parkinsonian state responses therapeutic stimulation, we...
Parkinson's disease (PD) is associated with excessive beta activity in the basal ganglia. Brain sensing implants aim to leverage this biomarker for demand-dependent adaptive stimulation. Sleep disturbance among most common non-motor symptoms PD, but its relationship unknown. To investigate clinical potential of as a sleep quality we recorded pallidal local field potentials during polysomnography PD patients off dopaminergic medication and compared results dystonia patients. exhibited...
Sleep disturbances are highly prevalent in movement disorders, potentially due to the malfunctioning of basal ganglia structures. Pallidal deep brain stimulation (DBS) has been widely used for multiple disorders and reported improve sleep. We aimed investigate oscillatory pattern pallidum during sleep explore whether pallidal activities can be utilized differentiate stages, which could pave way sleep-aware adaptive DBS.We directly recorded over 500 h local field potentials from 39 subjects...
Temporal interference (TI) stimulation, a novel non-invasive stimulation strategy, has recently been shown to modulate neural activity in deep brain regions of living mice. Yet, it is uncertain if this method applicable larger brains and whether the electric field produced under traditional safety currents can penetrate as observed Despite recent model-based simulation studies offering positive evidence at both macro- micro-scale levels, absence electrophysiological data from actual hinders...
Abstract Subthalamic nucleus deep brain stimulation (STN-DBS) has the potential to delay Parkinson’s disease (PD) progression. Whether oxidative stress participates in neuroprotective effects of DBS and related signaling pathways remains unknown. To address this, we applied STN-DBS mice monkey models PD collected tissue evaluate mitophagy, stress, pathway. confirm findings animal experiments, a cohort patients was recruited evaluated cerebrospinal fluid. When received STN stimulation, mTOR...
Abstract The serine protease inhibitor clade E member 1 (SERPINE1) is a key modulator of the plasminogen/plasminase system and has been demonstrated to promote tumor progression metastasis in various tumours. However, although much literature explored cancer‐promoting mechanism SERPINE1, pan‐cancer analyses its predictive value immune response remain unexplored. differential expression, survival analysis SERPINE1 expression multiple cancers were analysed using Cancer Genome Atlas...
Comparatively high excitability of myelinated fibers suggests that they represent a major mediator deep brain stimulation effects. Such effects can be modeled using different levels abstraction, ranging from simple electric field estimates to complex multicompartment axon models. In this study, we explore three approaches estimate axonal activation: magnitudes, projections and (probabilistic) pathway activation modeling. Our aim is describe these also illustrate their relevance. For that,...
Gastric cancer (GC) is one of the most malignant tumors that seriously threaten human health. Increased reports have indicated long noncoding RNAs (lncRNAs) are associated with GC. This study aims to investigate regulatory role colon cancer-associated transcript-1 (CCAT1) in The results exhibited fact CCAT1 was expressed higher 57 GC tissue samples than paired adjacent normal samples. expression also increased cell lines (MKN45, Hs746T, and SGC-7901) compared gastric epithelial line GES-1....
Background: Freezing of gait (FOG) is a common disabling symptom in Parkinson’s disease (PD). Cognitive impairment may contribute to FOG. Nevertheless, their correlations remain controversial. We aimed investigate cognitive differences between PD patients with and without FOG (nFOG), explore severity performance assess heterogeneity within the patients. Methods: Seventy-four (41 FOG, 33 nFOG) 32 healthy controls (HCs) were included. Comprehensive neuropsychological assessments testing...
Parkinson’s disease (PD) is a progressive neurodegenerative disorder characterized by the presence of α-synuclein (α-Syn)-rich Lewy bodies (LBs) and preferential loss dopaminergic (DA) neurons in substantia nigra (SN) pars compacta (SNpc). However, widespread involvement other central nervous systems (CNS) structures peripheral tissues now widely documented. The onset molecular cellular neuropathology PD likely occurs decades before motor symptoms characteristic PD, so early diagnosis...
Strategies of far infrared drying (FID) and combined with hot air (FIHAD) were employed to preserve the quality Anoectochilus. It was dried four different temperatures (50, 60, 70 80 °C) under FID three FIHAD. After drying, kinetics, color, aroma Anoectochilus investigated. Results showed that FIHAD strategy decreased time in processing; it also retained better bioactive compound than FID. Optimal samples arised from FIHAD60 °C which product quality. model Modified Henderson & Pabis...
Abstract Background and Objectives Matrix metalloproteinases (MMPs) are one of the major classes proteolytic enzymes involved in tumor invasion metastasis, being inhibited by naturally occurring tissue inhibitors (TIMPs). We examined mRNA expression for MMP‐2, MMP‐7, MMP‐9, MT1‐MMP, TIMP‐1, TIMP‐2 human gastric adenocarcinoma tissues, correlation between their clinicopathological variables. Methods Gastric samples from 72 patients with were available this study. To determine TIMP‐2,...