A5042443032- Neurological disorders and treatments
- Parkinson's Disease Mechanisms and Treatments
- EEG and Brain-Computer Interfaces
- Genetic Neurodegenerative Diseases
- Transcranial Magnetic Stimulation Studies
- Obsessive-Compulsive Spectrum Disorders
- Autism Spectrum Disorder Research
- Renal and related cancers
- Non-Invasive Vital Sign Monitoring
- Obstructive Sleep Apnea Research
- Botulinum Toxin and Related Neurological Disorders
- Tissue Engineering and Regenerative Medicine
- Sleep and Wakefulness Research
- Restless Legs Syndrome Research
- Meningioma and schwannoma management
- Genetic Syndromes and Imprinting
- Radioactive Decay and Measurement Techniques
- Ocular and Laser Science Research
- Bone Tumor Diagnosis and Treatments
- Nonlinear Optical Materials Studies
- Color perception and design
- Body Image and Dysmorphia Studies
- Head and Neck Surgical Oncology
- Mesenchymal stem cell research
- Color Science and Applications
Capital Medical University
2021-2024
Beijing Institute of Neurosurgery
2024
Beijing Tian Tan Hospital
2021-2024
BOE Technology Group (China)
2023-2024
Central South University
2019-2020
Parkinson's disease (PD) is associated with excessive beta activity in the basal ganglia. Brain sensing implants aim to leverage this biomarker for demand-dependent adaptive stimulation. Sleep disturbance among most common non-motor symptoms PD, but its relationship unknown. To investigate clinical potential of as a sleep quality we recorded pallidal local field potentials during polysomnography PD patients off dopaminergic medication and compared results dystonia patients. exhibited...
Sleep disturbances are highly prevalent in movement disorders, potentially due to the malfunctioning of basal ganglia structures. Pallidal deep brain stimulation (DBS) has been widely used for multiple disorders and reported improve sleep. We aimed investigate oscillatory pattern pallidum during sleep explore whether pallidal activities can be utilized differentiate stages, which could pave way sleep-aware adaptive DBS.We directly recorded over 500 h local field potentials from 39 subjects...
Abstract Subthalamic nucleus deep brain stimulation (STN-DBS) has the potential to delay Parkinson’s disease (PD) progression. Whether oxidative stress participates in neuroprotective effects of DBS and related signaling pathways remains unknown. To address this, we applied STN-DBS mice monkey models PD collected tissue evaluate mitophagy, stress, pathway. confirm findings animal experiments, a cohort patients was recruited evaluated cerebrospinal fluid. When received STN stimulation, mTOR...
Background: Freezing of gait (FOG) is a common disabling symptom in Parkinson’s disease (PD). Cognitive impairment may contribute to FOG. Nevertheless, their correlations remain controversial. We aimed investigate cognitive differences between PD patients with and without FOG (nFOG), explore severity performance assess heterogeneity within the patients. Methods: Seventy-four (41 FOG, 33 nFOG) 32 healthy controls (HCs) were included. Comprehensive neuropsychological assessments testing...
Abstract The effect of subthalamic nucleus deep brain stimulation (STN-DBS) on balance function in patients with Parkinson’s disease (PD) and the potential outcome predictive factors remains unclear. We retrospectively included 261 PD who underwent STN-DBS finished 1-month follow-up (M1) assessment explorative set for identifying postoperative change predictors, 111 both M1 12-month (M12) validation verifying identified factors. Motor improvement were evaluated through UPDRS-III Berg scale...
There are many documented sex differences in the clinical course, symptom expression profile, and treatment response of Parkinson's disease, creating additional challenges for patient management. Although subthalamic nucleus deep brain stimulation is an established therapy effects on outcome still unclear. The aim this retrospective observational study, was to examine motor symptoms, non-motor quality life after stimulation. Outcome measures were evaluated at 1 12 months post-operation 90...
Rapid eye movement (REM) sleep behaviour disorder (RBD) is one of the most common problems and represents a key prodromal marker in Parkinson's disease (PD). It remains unclear whether how basal ganglia nuclei, structures that are directly involved pathology PD, implicated occurrence RBD.
Abstract Sleep disturbances profoundly affect the quality of life in individuals with neurological disorders. Closed-loop deep brain stimulation (DBS) holds promise for alleviating sleep symptoms, however, this technique necessitates automated stage decoding from intracranial signals. We leveraged overnight data 121 patients movement disorders (Parkinson’s disease, Essential Tremor, Dystonia, Huntington’s and Tourette’s syndrome) whom synchronized polysomnograms basal ganglia local field...
Abstract Background Previous studies have reported the effects of age and disease duration on efficacy subthalamic nuclei deep brain stimulation (STN‐DBS) Parkinson's (PD) patients. However, available data involving these issues are not consistent. In particular, effect initial STN‐DBS has been established. Methods A total 51 patients with PD treated bilateral were involved in present study. They received clinical symptom evaluation during preoperative, initial, chronic stages surgery. The...
Subthalamic nucleus deep brain stimulation (STN-DBS) improves sleep qualities in Parkinson's disease (PD) patients; however, it remains elusive whether STN-DBS by directly influencing the circuit or alleviates other cardinal symptoms such as motor functions, confounding factors including intensity may also involve. Studying effect of microlesion (MLE) on after electrode implantation address this issue.To examine influence MLE quality and related PD, well effects regional lateral specific...
The impact of packaging film has been discussed for the uniformity mini LED screen. It is found that variation transmittance should be controlled in a limited range which about 5% to ensure display at side viewing angle.
When viewing the Mini LED display screen from a large angle, color seam appearing at edge of module can disrupt uniformity entire screen's bright state. This paper studies formation mechanism and solves problem by optimizing packaging film structure.
<title>Abstract</title> Obsessive-Compulsive Disorder (OCD) is characterized by persistent intrusive thoughts and compulsive behaviors that are often resistant to traditional treatment methods such as medication psychotherapy. Neuromodulation, targeting specific brain circuits, has emerged a promising alternative for treating refractory OCD. This study aims synthesize the effectiveness of various neuromodulation techniques, focusing particularly on their impact neural circuitry based...
Abstract Objective To examine the influence of microlesion effect (MLE) after subthalamic nucleus (STN) deep brain stimulation (DBS) on sleep quality in Parkinson’s disease (PD) patients and correlates changes. Methods In 78 PD who underwent bilateral STN-DBS surgery, we assessed compared qualities, motor performances, anti-parkinsonian drug dosage, emotional conditions at preoperative baseline before implantable pulse generator activation (i.e., 1-month postoperatively). We determined...