A5100411012- Neurological disorders and treatments
- Parkinson's Disease Mechanisms and Treatments
- Neuroscience and Neural Engineering
- Hepatitis B Virus Studies
- Adipokines, Inflammation, and Metabolic Diseases
- Transcranial Magnetic Stimulation Studies
- Immune Response and Inflammation
- Botulinum Toxin and Related Neurological Disorders
- Hepatitis C virus research
- Intracerebral and Subarachnoid Hemorrhage Research
- Lipid metabolism and disorders
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Cancer, Lipids, and Metabolism
- Liver Disease Diagnosis and Treatment
- Intracranial Aneurysms: Treatment and Complications
- Respiratory viral infections research
- Dental Health and Care Utilization
- Vascular Malformations Diagnosis and Treatment
- Pediatric health and respiratory diseases
- Oral microbiology and periodontitis research
- Neurological diseases and metabolism
- Nuclear Receptors and Signaling
- Computational Drug Discovery Methods
- Influenza Virus Research Studies
Xinjiang Medical University
2025
Shanxi University
2024
Fujian Medical University
2024
First Affiliated Hospital of Fujian Medical University
2024
Beijing Tian Tan Hospital
2013-2023
Capital Medical University
2013-2023
West China Medical Center of Sichuan University
2022
Beijing Institute of Neurosurgery
2013-2022
Peking University First Hospital
2022
Peking University
2022
Abstract Background There are often many missing values in medical data, which directly affect the accuracy of clinical decision making. Discharge assessment is an important part Taking discharge patients with spontaneous supratentorial intracerebral hemorrhage as example, this study adopted data processing evaluation criteria more suitable for making, aiming at systematically exploring performance and applicability single machine learning algorithms ensemble (EL) under different scenarios,...
Abstract The effect of subthalamic nucleus deep brain stimulation (STN-DBS) on balance function in patients with Parkinson’s disease (PD) and the potential outcome predictive factors remains unclear. We retrospectively included 261 PD who underwent STN-DBS finished 1-month follow-up (M1) assessment explorative set for identifying postoperative change predictors, 111 both M1 12-month (M12) validation verifying identified factors. Motor improvement were evaluated through UPDRS-III Berg scale...
Objective This study aims to investigate the prevalence of familial cerebral cavernous malformations (FCCMs) in first-degree relatives (FDRs) using screening, describe distribution initial symptoms, lesion count on cranial MRI and pathogenic gene patients. Methods Patients with multiple CCMs who enrolled from Treatments Outcomes Untreated Cerebral Cavernous Malformations China database were considered as probands FDRs recruited. Cranial was performed screen lesions, whole-exome sequencing...
Background Opiate addiction remains intractable in a large percentage of patients, and relapse is the biggest hurdle to recovery. Many studies have identified central role nucleus accumbens (NAc) addiction. Deep brain stimulation (DBS) has advantages being reversible, adjustable, minimally invasive, it become potential neurobiological intervention for The purpose our study was investigate whether high-frequency DBS NAc effectively attenuates reinstatement morphine seeking morphine-primed...
Abstract Background Subthalamic nucleus (STN) deep brain stimulation (DBS) is an effective treatment for Parkinson's disease (PD), that can improve patients' motor and non‐motor symptoms. However, there are differences in the improvement of emotional symptoms cognitive function. Objective To investigate impact active contact location volume tissue activated (VTA) on function STN‐DBS PD. Methods A total 185 PD patients were included this study. We evaluated them using Movement Disorder...
Regional cortical thickness or volume analyses based upon structural MRI scans have been employed to study the pathophysiology of primary craniocervical dystonia (CCD). In present study, brain connectivity network morphological distribution similarities among different areas were used disruption in individuals affected by CCD.The T1 completed for 37 patients with CCD and 30 healthy controls, individual networks being constructed gray matter (GM) 90 regions within brain. Area under curve...
Effective drugs and strategies for treating type 2 diabetes mellitus (2‑DM) are urgently required. The aim of the present study was to elucidate mechanism underlying microRNA (miR)‑6835‑3p regulation adiponectin receptor 1 (AdipoR1) expression miR‑6835‑3p/AdipoR1 signaling pathway in pancreatic islet cells. In addition, potential anti‑diabetes effect miR‑6835‑3p on insulin secretion investigated. Luciferase activity analysis performed evaluate how targets 3'‑untranslated region AdipoR1....
Abstract Background Deep-brain stimulation targeting the subthalamic nucleus (STN) can be used to treat motor symptoms and dyskinesia in advanced stages of Parkinson’s disease (PD). High-frequency (HFS) STN lead consistent, long-term improvement PD symptoms. However, effects HFS on axial PD, specifically freezing gait, limited or cause further impairment. While this alleviated via relatively low-frequency (LFS) selected patients, LFS does not control all PD. Recently, National Engineering...
Evidence has shown that the CUB and Sushi Multiple Domains (CSMD1) gene is an inhibitor of complement activation pathway also involved in central nervous system inflammation. Previous studies have revealed CSMD1 related to familial Parkinson’s disease. This study aimed investigate relationship between susceptibility disease population northern China. A case-control was performed on 423 patients 465 healthy controls matched for age sex. DNA from enrolled subjects were extracted peripheral...
We aimed to explore the differences in plasma biomarker levels between patients with familial cerebral cavernous malformations (FCCM) and their healthy first-degree relatives (FDRs) FCCM without severe chronic disease aggressiveness (CDA).
Objective To study the variation of hemorheology in patients with chronic hepatitis B and its relations HBV DNA, liver function oxidative stress markers. Methods Indices for hemorheology, markers, function, DNA were measured 55 correlative analysis was made. Results The low-shear whole blood viscosity (BV), RBC aggregation index significantly higher group than those control (P0.05), Hematocrit (HCT), BV, whose ALT normal controls. No significant difference found indices hemorheology(P0.05),...
Objective To explore the treatment efficacy of variable frequency stimulation (VFS) subthalamic nucleus (STN) on freezing gait (FOG) in patients with Parkinson's disease (PD). Methods Seven PD were treated by VFS from May 2016 to July 2017 at Department Neurosurgery, Beijing Tiantan Hospital, Capital Medical University. Those had failed improve their FOG STN high (HFS). All followed up outpatient clinic following VFS-STN stimulation. The third part Unified Disease Rating Scale...
Objective: The aim of this study is to evaluate the evolution GPi DBS targeting. Methods: This retrospective, single-center included patients implanted with leads for dystonia or PD during years 2004 2018 at University Florida Fixel Institute Neurological Diseases. Each patient underwent a high-resolution targeting on day prior surgery, which was fused high resolution CT scan that acquired procedure. Intraoperative target location selected using digitized 3D Schaltenbrand-Bailey atlas. All...
Objective To investigate the curative effect of leflunomide in treatment diabetic nephropathy-Ⅳ (DN-Ⅳ).Methods Sixty cases with DN-Ⅳ were assigned to group and control group.Both groups given hypoglycemic,antihypertensive,regulate lipid angiotensin converting enzyme inhibitors or Ⅱ inhibitor class drugs.Meanwhile patients orally administered once daily for two month a dose 50 mg/d first three days 20 afterwards.24 hour pre-and post-treatment values urinary protein,C-reactive protein...
Objective To investigate the clinical values and suggestions for use of domestically developed technology remote programming patients with movement disorders. Methods A total 56 disorders underwent implantation manufactured devices deep brain stimulation (DBS) at Department Neurosurgery, Beijing Tiantan Hospital affiliated to Capital Medical University from February 2016 October 2017. All received programing post surgery. The types were summarized side effects...
Objective To evaluate the long-term safety and efficacy of subthalamic nucleus deep brain stimulation (STN-DBS) with a PINS stimulator in Parkinson's disease (PD). Methods Fifty patients received device implantation from November 2009 to August 2012 at Neurosurgery Department Beijing Tiantan Hospital, Capital Medical University were retrospectively enrolled into this study. The effects on motor score, activities daily living, levodopa-equivalent dose, side analyzed for all 50 PD...