The effect of variable frequency stimulation of subthalamic nucleus on freezing gait of patients with Parkinson's disease

• DOI: 10.3760/cma.j.issn.1001-2346.2017.11.010
• Publication Date: 2017-11-28
• Authors: Huimin Wang; Yin Jiang; Xin Zhang; Fangang Meng; Kai Zhang
• Keywords: Subthalamic Nucleus

Objective To explore the treatment efficacy of variable frequency stimulation (VFS) subthalamic nucleus (STN) on freezing gait (FOG) in patients with Parkinson's disease (PD).

Methods Seven PD were treated by VFS from May 2016 to July 2017 at Department Neurosurgery, Beijing Tiantan Hospital, Capital Medical University. Those had failed improve their FOG STN high (HFS). All followed up outpatient clinic following VFS-STN stimulation. The third part Unified Disease Rating Scale (UPDRS-Ⅲ) and Freezing Gait Questionnaire (FOGQ) employed patient's motor improvement.

Results In early stage VFS, UPDRS-III score was significantly lower than that baseline (23.3±8.1 vs. 45.3±7.2, P 0.05). FOGQ baseline(11.7±6.1 17.3±5.1, P<0.05). improvement rate higher for VHS HFS [(45.6±22.7)% (13.8±10.9)%, P<0.05]. follow-up time 3-12 months (mean, 7.3±4.0 months). At this time, (19.9±7.0) (56.2±15.8)%, which (P<0.05) but not different stage. (11.0±5.7). (48.0±19.4)%, stage.

Conclusion For relief PD, effect could be more remarkable stable.

Key words: Parkinson's disease; Deep brain stimulation; Subthalamic nucleus; Freezing gait; Variable