A5024601689- Epilepsy research and treatment
- Neurological disorders and treatments
- Tuberous Sclerosis Complex Research
- Vagus Nerve Stimulation Research
- Neurogenetic and Muscular Disorders Research
- Pharmacological Effects and Toxicity Studies
- Genetics and Neurodevelopmental Disorders
- Polyomavirus and related diseases
- EEG and Brain-Computer Interfaces
- Obsessive-Compulsive Spectrum Disorders
- Neuroscience and Neuropharmacology Research
- Hereditary Neurological Disorders
- Genetic and Kidney Cyst Diseases
- Genetic Neurodegenerative Diseases
- Genomics and Rare Diseases
- Drug Transport and Resistance Mechanisms
- Neuroscience and Neural Engineering
- Neurological diseases and metabolism
- Trigeminal Neuralgia and Treatments
- Spinal Dysraphism and Malformations
- Advanced MRI Techniques and Applications
- Immunodeficiency and Autoimmune Disorders
- Fetal and Pediatric Neurological Disorders
- Advanced Neuroimaging Techniques and Applications
- Functional Brain Connectivity Studies
Capital Medical University
2016-2025
Beijing Children’s Hospital
2018-2025
Ministry of Education of the People's Republic of China
2022
Xijing Hospital
2022
Beijing Institute of Neurosurgery
2016-2018
Summary Objective We aimed to study the networks’ mechanism of metabolic covariance networks in mesial temporal lobe epilepsy (mTLE), through examining brain value fluorine‐18‐fluorodeoxyglucose positron emission tomography ( 18 F‐FDG‐PET). Methods F‐FDG‐PET images from 16 patients with mTLE were analyzed using local and global network (MCN) approaches, including whole pattern analysis (WMPA), hippocampus‐based (h‐) MCN, (w‐) edge‐based connectivity (EBCA). Results WMPA showed a typical...
Fluorine-18-fluorodeoxyglucose positron-emission tomography (18F-FDG-PET) is widely used to help localize the hypometabolic epileptogenic focus for presurgical evaluation of drug-refractory epilepsy patients. Two voxel-based brain mapping methods interpret 18F-FDG-PET, statistical parametric (SPM) and three-dimensional stereotactic surface projection (3D-SSP), improve detection rate seizure foci. This study aimed compare consistency epileptic between SPM 3D-SSP 18F-FDG-PET analysis.We...
Positron emission tomography (PET) scan with tracer [18F]-fluorodeoxy-glucose (18F-FDG) is widely used to measure the glucose metabolism in neurodegenerative disease such as Idiopathic Parkinson's (IPD). Previous studies using 18F-FDG PET mainly focused on motor or non-motor symptoms but not severity of IPD. In this study, we aimed determine metabolic patterns different stages IPD defined by Hoehn and Yahr rating scale (H-Y scale) identify regions brain that play critical roles progression....
Vagus nerve stimulation balanced disrupted default-mode network and salience in a postsurgical epileptic patient Kailiang Wang,1,2 Qi Chai,1 Hui Qiao,1 Jianguo Zhang,2,3 Tinghong Liu,1,2 Fangang Meng,1,2 1Beijing Neurosurgical Institute, Capital Medical University, 2Beijing Key Laboratory of Neurostimulation, 3Department Neurosurgery, Beijing Tiantan Hospital, Beijing, People’s Republic China Introduction: In recent years, treatment intractable epilepsy has become more challenging, due...
Objectives: To evaluate the value of fast ripples (FRs) (200–500 Hz) recorded with stereo-electroencephalograph (SEEG) in localization epileptogenic tubers patients tuberous sclerosis complex (TSC). Methods: Seventeen TSC who underwent preoperative SEEG examination and resective epilepsy surgery were retrospectively enrolled. They divided into two groups according to seizure control at 1-year postoperative follow-up. The occurrence frequencies FRs automatically counted, FR rate was...
To analyze the interictal discharge (IID) patterns on pre-operative scalp electroencephalogram (EEG) and compare changes in IID after removal of epileptogenic tubers preschool children with tuberous sclerosis complex (TSC)-related epilepsy.Thirty-five who underwent resective surgery for TSC-related epilepsy were enrolled retrospectively, their EEG data collected before to 3 years analyzed.Twenty-three (65.7%) patients seizure-free post-operatively at 1-year follow-up, 37-40% post-operative...
Background: Pediatric epilepsy is the most common disease of pediatric neurological diseases in China. Current demographic characteristics and economic burdens are needed to guide public health policy. In this study, we provide burden patients China from 2016 2021, describe change trend correlation by province. Methods: Using data Futang Research Center Development, conducted a demographic-based cross-sectional study 29 children’s hospitals assess changes distribution over 6 years related...
<b><i>Background:</i></b> Focal cortical dysplasia (FCD) is one of the most important pathogenic findings in patients with extratemporal lobe epilepsy. Magnetic resonance imaging (MRI)-negative negative factor to predict postoperative seizure freedom; however, FCD-I and part FCD-IIa are MRI-negative on routine MRI. <b><i>Objectives:</i></b> To explore diagnostic values 7T MRI its new scan sequences epilepsy FCD-IIa....
Tuberous sclerosis complex (TSC) is a rare disease that involves multiple organs, including the brain; approximately 80%-90% of TSC patients exhibit TSC-associated epilepsy. Independent temporal lobe epilepsy (TLE), TSC-unrelated epilepsy, particularly in with TSC. Here, we describe three independent TLEs were confirmed by stereo-electroencephalography (EEG), postoperative pathological findings, and seizure outcome at follow-up. The retrospectively enrolled two centers; their ictal...
2例KMT2B基因变异致肌张力障碍28型男性患儿，分别在2岁和2岁6月龄无诱因以下肢足尖行走起病，进行性加重，扭转痉挛逐渐波及双上肢、躯干、颈部。例1曾出现肌张力障碍持续状态表现。例2有家族史。2例患儿口服药物治疗均无效，例1行脑深部电刺激治疗后症状逐渐改善。例1为KMT2B新生变异c.7550G>T，为未报道新变异。例2及其姐姐、母亲、舅舅、外祖母均为遗传性KMT2B变异c.1656dupC，为已报道变异。.
Preliminary analysis of the effect vagus nerve stimulation in treatment children with intractable epilepsy
The first Chinese family with paroxysmal non-kinesigenic dystonia (PNKD) was confirmed to harbour a PNKD mutation. However, the pathogenic mechanism of PNKD-causing gene mutation unclear.Wild-type and mutant PNKD-L plasmids were prepared transfected into C6 cell line study distribution stability protein in cells its effect on glutathione content. blood cerebrospinal fluid (CSF) 3 patients healthy controls collected. differentially expressed proteins identified using isobaric tags for...