A5091767073- Neurological disorders and treatments
- Parkinson's Disease Mechanisms and Treatments
- Neuroscience and Neuropharmacology Research
- Transcranial Magnetic Stimulation Studies
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- RNA regulation and disease
- Genetics and Neurodevelopmental Disorders
- Adenosine and Purinergic Signaling
- Circular RNAs in diseases
- Functional Brain Connectivity Studies
- Autism Spectrum Disorder Research
- Neuroscience and Neural Engineering
- Neural dynamics and brain function
- Genetic Neurodegenerative Diseases
- Machine Learning in Bioinformatics
- Neurological Disease Mechanisms and Treatments
- Neural and Behavioral Psychology Studies
- Epilepsy research and treatment
- Botulinum Toxin and Related Neurological Disorders
- RNA Research and Splicing
- Mitochondrial Function and Pathology
- Memory and Neural Mechanisms
- Advanced Measurement and Detection Methods
- RNA modifications and cancer
Capital Medical University
2014-2024
Beijing Tian Tan Hospital
2020-2024
Beijing Institute of Neurosurgery
2015-2024
Xuan Wu Hospital of the Capital Medical University
2023
Binzhou University
2023
Binzhou Medical University
2023
Capital University
2021
Beijing Municipal Education Commission
2017-2021
Astrocyte and microglia activation are well-known features of temporal lobe epilepsy that may contribute to epileptogenesis. However, the mechanisms underlying glia not well understood. Long non-coding RNA (lncRNA) H19 has diverse functions depending on physiological or pathological state, its role in is unknown. We previously demonstrated was significantly upregulated latent period be associated with cell proliferation immune inflammatory responses. therefore speculated involved hippocampal...
Abstract Temporal lobe epilepsy (TLE) is one of the most common types intractable epilepsy, characterized by hippocampal neuron damage and sclerosis. Long noncoding RNAs (lncRNAs) have been increasingly recognized as posttranscriptional regulators. However, their expression levels functions in TLE remain largely unknown. In present study, rat model used to explore profiles lncRNAs hippocampus epileptic rats using microarray analysis. Our results demonstrate that H19 pronouncedly...
Impaired activation and regulation of the extinction inflammatory cells molecules in injured neuronal tissues are key factors development epilepsy. SerpinA3N is mainly associated with acute phase response response. In our current study, transcriptomics analysis, proteomics Western blotting showed that expression level Serpin clade A member 3N (SerpinA3N) significantly increased hippocampus mice kainic acid (KA)-induced temporal lobe epilepsy, this molecule expressed astrocytes. Notably, vivo...
Parkinson's disease (PD) is a common movement disorder for which diagnosis mainly depends on the medical history and clinical symptoms. Exosomes are now considered an additional mechanism intercellular communication, allowing cells to exchange proteins, lipids, genetic material. Long noncoding (lnc) RNA in exosomes plays critical role many diseases, including neurodegenerative disease.To study expression differences lncRNAs peripheral blood of PD patients compared with healthy individuals...
Deep brain stimulation (DBS) is an emerging and effective therapy for Parkinson's disease (PD). However, little known about its utilization, surgical populations, centers, coverages, regional balance, influential factors. This large-scale multicenter cross-sectional study was conducted using a national census involving 74 Chinese centers. National DBS populations centers PD were investigated in 1997-2021, sociodemographic features, related resources, insurance policies 2020 explored. Since...
Abstract Objectives Glial cell activation contributes to the inflammatory response and occurrence of epilepsy. Our preliminary study demonstrated that long non‐coding RNA, H19, promotes hippocampal glial during epileptogenesis. However, precise mechanisms underlying this effect remain unclear. Materials methods H19 let‐7b were overexpressed or silenced using an adeno‐associated viral vector in vivo. Their expression a kainic acid‐induced epilepsy model was evaluated by real‐time quantitative...
Abstract Objective To compare the efficacy of subthalamic nucleus (STN) and globus pallidus internus (GPi) deep brain stimulation (DBS) on reducing levodopa‐induced dyskinesia (LID) in Parkinson’s disease, to explore potential underlying mechanisms. Methods We retrospectively assessed clinical outcomes 43 patients with preoperative LID who underwent DBS targeting STN (20/43) or GPi (23/43). The primary outcome was change from baseline Unified Dyskinesia Rating Scale (UDysRS) secondary...
Abstract Empathy enables understanding and sharing of others’ feelings. Human neuroimaging studies have identified critical brain regions supporting empathy for pain, including the anterior insula (AI), cingulate (ACC), amygdala, inferior frontal gyrus (IFG). However, to date, precise spatio-temporal profiles empathic neural responses inter-regional communications remain elusive. Here, using intracranial electroencephalography, we investigated electrophysiological signatures vicarious pain...
Abstract Background To investigate the relationship between position of bilateral STN-DBS location active contacts and clinical efficacy on motor symptoms in Parkinson’s disease (PD) patients. Methods Retrospectively analyze data 57 patients with PD who underwent from March 2018 to December 2018. Unified Disease Rating Scale-Part III (UPDRS-III) score, levodopa equivalent day dose (LEDD), Quality Life Scale (PDQ-39) before operation within 6 months after operation, determine activated volume...
Summary Objective We aimed to study the networks’ mechanism of metabolic covariance networks in mesial temporal lobe epilepsy (mTLE), through examining brain value fluorine‐18‐fluorodeoxyglucose positron emission tomography ( 18 F‐FDG‐PET). Methods F‐FDG‐PET images from 16 patients with mTLE were analyzed using local and global network (MCN) approaches, including whole pattern analysis (WMPA), hippocampus‐based (h‐) MCN, (w‐) edge‐based connectivity (EBCA). Results WMPA showed a typical...
Abstract Background Deep brain stimulation (DBS) is a promising therapy for refractory Gilles de la Tourette syndrome (GTS). However, its long-term efficacy, safety, and recommended surgical age remain controversial, requiring evidence to compare different categories. Methods This retrospective cohort study recruited 102 GTS patients who underwent DBS between October 2006 April 2022 at two national centers. Patients were divided into categories: children (aged < 18 years; n = 34) adults ≥...
Positron emission tomography (PET) scan with tracer [18F]-fluorodeoxy-glucose (18F-FDG) is widely used to measure the glucose metabolism in neurodegenerative disease such as Idiopathic Parkinson's (IPD). Previous studies using 18F-FDG PET mainly focused on motor or non-motor symptoms but not severity of IPD. In this study, we aimed determine metabolic patterns different stages IPD defined by Hoehn and Yahr rating scale (H-Y scale) identify regions brain that play critical roles progression....
Abstract Background Parkinson's disease (PD) is the second most common neurodegenerative disease. Exosomes are endosome‐derived extracellular vesicles that can take part in intercellular communication. Circular RNAs (circRNAs) noncoding characterized by covalently closed‐loop structures, which perform a crucial function many diseases. Aim To clarify expression and of exosomal circRNSs PD patients look for circRNAs might be related to pathogenesis PD. Materials Methods We examined circRNA...
Although abnormal hippocampal structure and impaired spatial memory have been revealed in a pilocarpine rat model of temporal lobe epilepsy (TLE), the brain functional network changes are still unclear. The aim present study was to investigate connectivity related hippocampus associated impairment TLE.Functional magnetic resonance imaging signals were recorded pilocarpine-treated rats controls by using 7.0 T scanner, independent component analysis performed determine network. Behavioral...
Abstract Background To study the effects of subthalamic nucleus-deep brain stimulation (STN-DBS) on autonomic dysfunctions in Parkinson’s disease (PD) patients. Methods A total 57 PD patients who underwent bilateral STN-DBS from March to December 2018, were retrospectively analyzed. Preplanned assessments at baseline and postoperatively 1, 3, 6 months also included Scales for Outcomes Disease-Autonomic questionnaire (SCOPA-Aut), Unified Disease Rating Scale (UPDRS) III score, levodopa...
Background Focal motor seizures that originate in the region are a considerable challenge because of high risk permanent deficits after resection. Deep brain stimulation subthalamic nucleus (STN-DBS) is potential treatment for epilepsy may enhance antiepileptic actions substantia nigra pars reticulata (SNr). Orexin and its receptors have relationship with both STN-DBS epilepsy. We aimed to investigate whether how STN inputs SNr regulate role orexin pathway this process. Methods A...
Introduction: Deep brain stimulation (DBS) is an effective therapy for resting tremor in Parkinson's disease (PD). However, quick and objective biomarkers quantifying the efficacy of DBS intraoperatively are lacking. Therefore, we aimed to study how modulates intraoperative neuromuscular pattern PD patients find predictive surface electromyography (sEMG) DBS. Methods: Intraoperative sEMG 39 with was measured on off respectively, during testing stage. Twelve signal features (time frequency...
Abstract Background Subthalamic nucleus (STN) deep brain stimulation (DBS) is an effective treatment for Parkinson's disease (PD), that can improve patients' motor and non‐motor symptoms. However, there are differences in the improvement of emotional symptoms cognitive function. Objective To investigate impact active contact location volume tissue activated (VTA) on function STN‐DBS PD. Methods A total 185 PD patients were included this study. We evaluated them using Movement Disorder...
Parkinson’s disease (PD) is the second most common neurodegenerative disease; it mainly occurs in elderly population. Cuproptosis a newly discovered form of regulated cell death involved progression various diseases. Combining multiple GEO datasets, we analyzed expression profile and immunity cuproptosis-related genes (CRGs) PD. Dysregulated CRGs differential immune responses were identified between PD non-PD substantia nigra. Two CRG clusters defined Immune analysis suggested that cluster 1...
Levodopa-induced dyskinesia (LID) is a common complication of chronic dopamine replacement therapy in the treatment Parkinson's disease (PD). Long noncoding RNAs regulate gene expression and participate many biological processes. However, role long LID not well understood. In present study, we examined lncRNA transcriptome profile rat model PD by RNA sequence got subset lncRNAs, which were gradually decreased during development LID. We further identified previously uncharacterized RNA,...