A5033441787- Neurological disorders and treatments
- Parkinson's Disease Mechanisms and Treatments
- Genetic Neurodegenerative Diseases
- Transcranial Magnetic Stimulation Studies
- Neuroscience and Neural Engineering
- Autism Spectrum Disorder Research
- Botulinum Toxin and Related Neurological Disorders
- Obsessive-Compulsive Spectrum Disorders
- 3D Shape Modeling and Analysis
- Robotics and Sensor-Based Localization
- 3D Surveying and Cultural Heritage
- EEG and Brain-Computer Interfaces
Beijing Institute of Neurosurgery
2011-2025
Capital Medical University
2022-2025
Beijing Tian Tan Hospital
2022-2024
This study investigated the subthalamic nucleus (STN) function and deep brain stimulation (DBS) effects on single-unit activity (SUA) in Parkinson's disease (PD) patients with dysarthria. After presurgical speech analysis, we recorded STN neuronal activities while PD (n = 16) articulated Chinese Pinyin consonants. The consonants were categorized by manner place of articulation for SUA cluster analysis. cohort was then divided into normal dysarthria groups based diadochokinetic (DDK)...
Abstract Aim Subthalamic nucleus deep brain stimulation (STN‐DBS) has been reported to be effective in treating motor symptoms Parkinson's disease (PD), which may attributed changes the network. However, association between morphology and initial STN‐DBS efficacy, as well performance of prediction using neuroimaging, not illustrated. Therefore, we aim investigate these issues. Methods In present study, 94 PD patients underwent bilateral STN‐DBS, efficacy was evaluated. Brain examined by...
Abstract Background Deep brain stimulation (DBS) is a promising therapy for refractory Gilles de la Tourette syndrome (GTS). However, its long-term efficacy, safety, and recommended surgical age remain controversial, requiring evidence to compare different categories. Methods This retrospective cohort study recruited 102 GTS patients who underwent DBS between October 2006 April 2022 at two national centers. Patients were divided into categories: children (aged < 18 years; n = 34) adults ≥...
Abstract Background Previous studies have reported the effects of age and disease duration on efficacy subthalamic nuclei deep brain stimulation (STN‐DBS) Parkinson's (PD) patients. However, available data involving these issues are not consistent. In particular, effect initial STN‐DBS has been established. Methods A total 51 patients with PD treated bilateral were involved in present study. They received clinical symptom evaluation during preoperative, initial, chronic stages surgery. The...
Treating epilepsy with deep brain stimulation (DBS) is attracting more and attention these years, especially the close loop method that gives stimuli when needed so implanted device will work longer. People have tried to detect seizure electrocorticogram (ECoG), but extra implants put risks it. We plan local field potential (LFP) recorded depth electrodes of traditional DBS. To prove validation this method, we anterior thalamic (ANT) rats who been induced acute temporal lobe (TLE) by kainic...