A5103222475- Oral microbiology and periodontitis research
- Oral Health Pathology and Treatment
- Atherosclerosis and Cardiovascular Diseases
- Lung Cancer Treatments and Mutations
- Advanced Breast Cancer Therapies
- Galectins and Cancer Biology
- Anesthesia and Neurotoxicity Research
- Polymer-Based Agricultural Enhancements
- Breast Cancer Treatment Studies
- Remote Sensing and Land Use
- Plant Ecology and Soil Science
- Neuroinflammation and Neurodegeneration Mechanisms
- Forest, Soil, and Plant Ecology in China
- Cardiovascular Function and Risk Factors
- Palliative Care and End-of-Life Issues
- Macrophage Migration Inhibitory Factor
- Fungal Biology and Applications
- Semantic Web and Ontologies
- MicroRNA in disease regulation
- Peripheral Neuropathies and Disorders
- Cardiac Ischemia and Reperfusion
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Service-Oriented Architecture and Web Services
- Streptococcal Infections and Treatments
First Affiliated Hospital of Xinjiang Medical University
2024-2025
Xinjiang Medical University
2024-2025
Harbin Medical University
2008-2025
Second Affiliated Hospital of Harbin Medical University
2008-2025
Affiliated Hospital of Guizhou Medical University
2024
Beijing University of Chinese Medicine
2024
Beijing Children’s Hospital
2023-2024
First Affiliated Hospital of Fujian Medical University
2015-2024
Fujian Medical University
2011-2024
Northwest Institute of Plateau Biology
2024
The present study investigated neural correlations underlying the psychological processing of stimuli with various degrees self-relevance. Event-related potentials were recorded for names that differ in their extent relevance to participant. Participants performed a three-stimulus oddball task. ERP results showed larger P2 averaged amplitudes highly self-relevant than moderately self-relevant, minimally and non-self-relevant names. N2 Highly elicited P3 which, turn, had values Minimally...
Abstract: Porcine reproductive and respiratory syndrome (PRRS), caused by the PRRS virus (PRRSV), is an economically devastating disease, causing daily losses of approximately $3 million to US pork industry. Current vaccines have failed completely prevent outbreaks. Recently, we shown that poly(lactic- co -glycolic) acid (PLGA) nanoparticle-entrapped inactivated PRRSV vaccine (NP-KAg) induces a cross-protective immune response in pigs. To further improve its efficacy, NP-KAg formulation was...
Abstract Dendritic cells (DCs) play a critical role in controlling T helper 2 (Th2) cell-dependent diseases, but the signaling mechanism that triggers this function is not fully understood. We showed p38α activity DCs was decreased upon HDM stimulation and dynamically regulated by both extrinsic signals Th2-instructive cytokines. p38α-specific deletion cDC1s cDC2s or macrophages promoted Th2 responses under stimulation. Further study Th2-cell differentiation modulating MK2−c-FOS−IL-12 axis....
Abstract Background The Triglyceride and Glucose (TyG) index has been found to have a strong correlation with the recurrence of acute ischemic stroke (AIS) poor patient outcomes. Nevertheless, relationship between TyG early neurological deterioration (END) not fully explored. Therefore, present study aims investigate potential association END. Methods A retrospective analysis 2129 patients diagnosed AIS January 2019 December 2022 at Second Affiliated Hospital Harbin Medical University....
Abstract It is important but challenging to innovate inorganic sonosensitizers with controlled biodegradability and enhanced sonodynamic chemodynamic activities harness remodel the immunosuppressive tumor microenvironment (TME) for awakening robust immune responses against metastatic cancers. Herein rational design defect engineering strategy of a pH‐responsive biodegradable sonozyme system in sulfide nanocages augmented cancer immunotherapy reported. A series highly defective Co 9 S 8‐x...
The efficient refactoring of natural product biosynthetic gene clusters (BGCs) for activating silent BGCs is a central challenge the discovery new bioactive products. Herein, we have developed simple and robust CRISETR (CRISPR/Cas9 RecET-mediated Refactoring) technique, combining clustered regulatory interspaced short palindromic repeats (CRISPR)/Cas9 RecET, multiplexed BGCs. By this approach, can be refactored through synergistic interaction between homologous recombination CRISPR/Cas9...
Purpose Patient management, care, and education are influenced by the core competencies of hematology nurses. Nurse specialists enhance patient safety nursing care quality. However, no study has constructed an index competence assessment for Design In this study, a literature review, theoretical analysis, group discussion were performed to construct competency evaluation system Methods Twenty-six experts from 7 provinces cities across China selected purposive sampling 2 rounds Delphi expert...
Diffuse large B-cell lymphoma (DLBCL) is the most common subtype of non-Hodgkin lymphoma, with significant clinical heterogeneity. Recent studies suggest that intratumoral microbiome may influence tumor microenvironment, affecting patient prognosis and therapeutic responses. This study aims to identify microbiome-related subtypes in DLBCL assess their impact on prognosis, immune infiltration, sensitivity. Transcriptomic data from 48 patients were obtained public databases. Consensus...
Background : This study aims to assess visfatin concentrations in serum and gingival crevicular fluid (GCF) investigate this relationship patients with type 2 diabetes mellitus (T2DM) chronic periodontitis (CP) before after non‐surgical periodontal treatment. Methods: Fifty‐four T2DM CP were recruited. The randomly divided into two groups: treatment control. Serum GCF glycated hemoglobin (HbA1c) levels measured by enzyme‐linked immunosorbent assay at different time points (at baseline 3 6...
To investigate the impact of hormone receptor (HR) on clinicopathological characteristics and prognosis human epidermal growth factor 2 (HER2)-positive breast cancer.Using Surveillance, Epidemiology, End Results database, we enrolled patients diagnosed with HER2-positive cancer between 2010 2016, which were successively assessed for eligibility categorized into HR + /HER2 HR-/HER2 subgroups. Clinicopathological undergone comparative analyses baseline distinctions calibrated by propensity...
Excessive activation of aldose reductase (AR) in the brain is a risk factor for aggravating cerebral ischemia injury. Epalrestat only AR inhibitor with proven safety and efficacy, which used clinical treatment diabetic neuropathy. However, molecular mechanisms underlying neuroprotection epalrestat remain unknown ischemic brain. Recent studies have found that blood-brain barrier (BBB) damage was mainly caused by increased apoptosis autophagy microvascular endothelial cells (BMVECs) decreased...
We investigated the involvement of Th17 cells and T-cell immunoglobulin mucin domain 3 (TIM-3) in Guillain-Barré syndrome (GBS) comparison to healthy subjects.Peripheral blood samples were obtained from 29 subjects GBS patients.Peripheral mononuclear (PBMCs) CD4(+) T stimulated with anti-CD3 anti-CD28 mAbs, absence or presence anti-TIM-3 mAb.mRNA levels TIM-3 transcription factor retinoic acid-related orphan receptor γt (RORγt) determined by RT-PCR expressed relative β-actin mRNA...
A considerable number of patients with breast cancer will suffer from brain metastasis in the advanced setting. The HER2 status serves as a significant prognostic factor and reference applying treatment for (BCBM).
Insulin resistance (IR) is the main cause of type 2 diabetes mellitus (T2DM). The specific targets and underlying mechanisms responsible for ameliorative effects stilbenoid compounds found in fenugreek seeds ameliorating IR require further study. Here, we were predicted by using network pharmacology prediction, molecular docking dynamics simulation approach common potential mechanismsof three (rhaponticin, desoxyrhaponticin, rhapontigenin) relation to T2DM IR. results showed that may improve...